Shuo Liu

Short-term aerobic pretreatment of swine manure enhances short-chain fatty acid production in anaerobic fermentation: performance and mechanisms

Bangjie Xiong, Ju Chen, Liangbin Zhao, Mengting Chen et autres

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Screening of anti-metastasis drugs by targeting angiopellosis and cancer cluster extravasation

Xiao Cheng, Mengrui Liu, Shiqi Hu, Kaiyue Zhang et autres

Metastasis accounts for 90% of cancer-related deaths. Extravasation is a necessary step for cancer metastasis. Currently, there are no drugs that specially target extravasation. Most cancer therapies target either proliferation or angiogenesis. We previously identified "angiopellosis" as the dominant mechanism by which …

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Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis

Junlang Li, Yujia Jing, Dylan Silkstone, Ke Cheng et autres

Idiopathic pulmonary fibrosis (IPF) remains an incurable form of interstitial lung disease with sub-optimal treatments that merely address adverse symptoms or slow fibrotic progression. Here, inhalable hsa-miR-30a-3p-loaded liposomes (miR-30a) for the treatment of bleomycin-induced pulmonary fibrosis in mice are presented. It was …

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Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction

Kaiyue Zhang, Hongyan Tao, Dashuai Zhu, Zhang Yue et autres

Self-amplifying RNA (saRNA) enables sustained protein expression from a single administration. In this study, we developed an intramuscular saRNA-lipid nanoparticle (saNppa-LNP) therapy encoding natriuretic peptide type A ( Nppa ) for cardioprotection. A single injection induced sustained pro–atrial natriuretic peptide (pro-ANP) secretion …

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Antibiotic sensitivity as a key Determinant: B. Subtilis Reshapes the Microecology to mitigate antibiotic resistance genes during composting

Xiaoxia Hao, Lijia Jiang, Mengting Chen, Shuo Liu et autres

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Synthetic bacterium-facilitated colonization of nitrogen-fixing bacteria for remodeling the rhizosphere microbiome and improving plant yield

Shuo Liu, Zirun Zhao, Yaoting Ji, Hangqi Zhu et autres

BACKGROUND: Nitrogen-fixing bacteria (NFBs) play a critical role in biological nitrogen fixation for supplying essential nitrogen nutrients to plants in agriculture and natural ecosystems. Especially, these bacteria and Leguminosae plants form symbiosis to improve plant growth and soil fertility. Theoretically, the inoculation …

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Distinct Dynamic Functional Connectivity Patterns in Tremor-Dominant and Gait Disturbance Subtypes of Parkinson’s Disease

Yihang Zhou, Wei Wei, Xinhui Wang, Shuo Liu et autres

Motivation: Understanding the neural mechanisms of tremor-dominant (TD) and postural instability/gait difficulty (PIGD) subtypes in Parkinson's disease is essential, however previous studies often overlooked the dynamic fluctuations of functional connectivity (dFC). Goal(s): This study aims to analyze the differences in dynamic functional …

Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy

Yong-Bo Lv, Dashuai Zhu, Junlang Li, Yuan Li et autres

Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component …

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Microneedle Delivery of Small Extracellular Vesicles From Young Blood to Treat Endothelial Senescence

Shiqi Hu, Zhenhua Li, Dashuai Zhu, Shuo Liu et autres

Circulating extracellular vesicles (EVs) play a crucial role in mediating communication between different cell populations and organs, significantly influencing inflammation and vascular diseases. To evaluate the role of EVs in regulating senescence, small EVs isolated from umbilical cord plasma (young sEVs, Y-sEVs) …

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Immunomodulatory microneedle patch for cardiac repair in rodent and porcine models of myocardial infarction

Ke Huang, Dashuai Zhu, Jennifer Soto, Shiqi Hu et autres

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Deciphering Virulence Factors of Hyper-Virulent Pseudomonas aeruginosa Associated with Meningitis.

Li Xie, Shuo Liu, Yu Wang, Ming Chun Li et autres

Objective: ) is a prevalent pathogenic bacterium involved in meningitis; however, the virulence factors contributing to this disease remain poorly understood. Methods: A584, isolated from meningitis samples, was evaluated by constructing in vitro blood-brain barrier and in vivo systemic infection models. qPCR, …

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Synthetic biology-assisted fungus-assembling beads for regulating rhizosphere microbiome and improving plant growth in saline soil

Yaoting Ji, Shuo Liu, Zirun Zhao, Fang Gu et autres

Soil salinization seriously reduces crop yields and threatens food security. Microbial inoculants have a wide prospect in the improvement of saline soil quality, while their soil colonization is frequently compromised. We previously isolated Trichoderma atroviride 1607 from the moss Brachythecium piligerum capable …

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