Ke Huang

Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair

Ke Huang, Shiqi Hu, Jhon Cores, Teng Su et autres

An acute myocardial infarction (AMI) induces a sterile inflammatory response that facilitates further heart injury and promotes adverse cardiac remodeling. Interleukin-1β (IL-1β) plays a central role in the sterile inflammatory response that results from AMI. Thus, IL-1β blockage is a promising strategy …

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Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling

Halle Lutz, Zhenhua Li, Ke Huang, Ke Cheng et autres

The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. …

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Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction

Kaiyue Zhang, Hongyan Tao, Dashuai Zhu, Zhang Yue et autres

Self-amplifying RNA (saRNA) enables sustained protein expression from a single administration. In this study, we developed an intramuscular saRNA-lipid nanoparticle (saNppa-LNP) therapy encoding natriuretic peptide type A ( Nppa ) for cardioprotection. A single injection induced sustained pro–atrial natriuretic peptide (pro-ANP) secretion …

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Modular bioreactor for multi-well electrical stimulation of in vitro cardiac tissue engineering constructs

Suh Hee Cook, Jack S. Twiddy, Yuan-Fang Li, Kiran M. Ali et autres

) related to cardiac electrophysiology compared to non-stimulated controls. This suggests 0.1 V stimulation with our bioreactor is advantageous for the electrophysiological function of primary cardiac cells; it may also be useful in electrophysiologically maturing induced pluripotent stem cell-derived cardiomyocytes.

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Efficacy of endovascular treatment for patients with acute large vessel occlusion stroke from the Western Sichuan Plateau and machine learning prediction models: a prospective study protocol

Yu Charlie Hu, Yuding Luo, Jiali Zhang, Pingchuan Liu et autres

Objectives: Stroke is the second leading cause of death and the third leading cause of disability among non-communicable diseases globally. The prevalence, incidence, and mortality rates of stroke are higher in high-altitude regions compared to lowland areas. However, compared to plain areas, …

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1891P Tislelizumab-based first-line therapy in advanced NSCLC: A real-world study

Tien‐Min Gabriel Chu, Ke Huang, Shangha Pan, Hai Lu et autres

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Author response for "Modular bioreactor for multi-well electrical stimulation of in vitro cardiac tissue engineering constructs"

Suh Hee Cook, Jack S. Twiddy, Yuan-Fang Li, Kiran M. Ali et autres

Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy

Yong-Bo Lv, Dashuai Zhu, Junlang Li, Yuan Li et autres

Ischemic injury and reperfusion injury collectively determine the total infarct size, a major prognostic factor following myocardial infarction (MI). Therefore, addressing both ischemic and reperfusion stages could substantially reduce infarct size and improve clinical outcomes. In this study, we develop a two-component …

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Immunomodulatory microneedle patch for cardiac repair in rodent and porcine models of myocardial infarction

Ke Huang, Dashuai Zhu, Jennifer Soto, Shiqi Hu et autres

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Stromal-platelet membrane-inspired nanoparticles (SPIN) for targeted heart repair

Mingqian He, Yuan Li, Dashuai Zhu, Junlang Li et autres

Myocardial infarction (MI), commonly known as a heart attack, remains a leading cause of death worldwide. Standard treatments, such as coronary stent placement or coronary artery bypass graft surgery, aim to restore blood flow to ischemic myocardial tissue. However, a significant complication …

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Author response for "Modular bioreactor for multi-well electrical stimulation of in vitro cardiac tissue engineering constructs"

Suh Hee Cook, Jack S. Twiddy, Yuan-Fang Li, Kiran M. Ali et autres

On-demand drug delivery bioelectronics through a water-processable low dimensional highly conductive MXene layer

Ke Huang, Yuan Li, Wubin Bai, Hyeok‐jin Kwon et autres

On-demand drug delivery holds great promise to optimize pharmaceutical efficacy while minimizing the side effects. However, existing on-demand drug delivery systems often require complicated manufacturing processes that preclude their wide implementation of a broad range of drugs. In this work, we demonstrate …

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