Yu Zhang

Microglial Dual Nature in Maintaining Spatiotemporal Homeostasis

Shunqi Wang, Yao Wang, Chunyang Hou, Yu Zhang et autres

Abstract Microglia are highly dynamic tissue-resident macrophages that continuously adapt their functional states to developmental, environmental, and pathological cues within the central nervous system (CNS). Rather than executing fixed genetic programs, microglial phenotypes emerge from continuous integration of developmental origin, regional niche, …

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A rapid evaluation method of dynamic response for fixed offshore monopile wind turbines combined with experimental and numerical validation

Yu Zhang, Yuhan Guo, Chen An, Zhenyu Zhou et autres

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Detection of Exosomal MicroRNA with Hybrid Plasmonic Nanoheater‐Driven PCR for Pulmonary Fibrosis Progression

Yu Zhang, Jin Li, Yixuan Wu, Yunqing Wang et autres

Abstract Pulmonary fibrosis (PF) is a severe respiratory disease, but early diagnosis of PF is challenging. Here, a non‐invasive approach is developed to rapidly detect bronchoalveolar lavage fluid (BALF)‐derived exosomal microRNAs (miRNAs) for PF progression based on hybrid nanoheater‐driven digital polymerase chain …

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Effects of exercise on cardiorespiratory fitness in children and adolescents with overweight and obesity: a systematic review and meta-analysis of 72 randomized controlled trials

Jie Men, Zhengyang Yu, Wei An, Peiling Wang et autres

Abstract Objective Evaluate the impact of exercise on the cardiorespiratory fitness of the children and adolescents with overweight or obesity, and explore possible influencing factors. Study design This meta-analysis adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines …

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Modalities Differentiation of Pain Perception Following Ischemic Stroke: Decreased Pressure Pain Perception

Yongkang Zhi, Chen Zhao, Yu Zhang, Jianzhang Ni et autres

Background/Objectives: Ischemic stroke frequently leads to somatosensory impairments and abnormal pain perception. Meanwhile, pain perception can be evoked through multiple somatosensory modalities, each mediated by distinct neural pathways. Despite this understanding, current research investigating stroke-induced alterations in pain perception across different modalities …

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Tumor Necrosis Factor Alpha-Mediated Interaction Between Microglia and Müller Cells Exacerbates Retinal Ganglion Cell Damage in Experimental Glaucoma

Shuying Li, Hong Zhou, Guoli Zhao, Wen‐Wen Ding et autres

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A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Guoli Zhao, Zhen Li, Shuying Li, Qing Xia et autres

Glaucoma is a neurodegenerative disease characterized by the progressive degeneration of retinal ganglion cells (RGCs) and their axons, ultimately leading to irreversible vision loss. Elevated intraocular pressure (IOP) is one of the significant risk factors in glaucoma; however, neurodegeneration continues even after …

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A Novel Frequency Domain Model for Dynamic Analysis of Floating Offshore Wind Turbines

Min Jun Lee, Yu Zhang, Menglan Duan, Miaozi Zheng et autres

Pain integration of multimodal noxious stimulation based on the perceptual instruction

Yu Zhang, Yongkang Zhi, Yu Zhang, Qiushi Li et autres

Individuals encounter various somatosensory inputs in their daily lives, often in multiple forms at once. When exposed to noxious stimuli, the intensity of these inputs can lead to a complex experience of pain. However, the mechanisms by which these harmful stimuli combine …

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Codelivery of NGFR100W and VEGFA mRNA Enhances Vascular and Neural Repair in Diabetic Peripheral Neuropathy

Wenjing Wang, Xiang Yang Yu, Zheng Yang, Yu Zhang et autres

Diabetic peripheral neuropathy (DPN) poses significant clinical challenges due to progressive nerve degeneration and vascular insufficiency. To address both neural and vascular complications simultaneously, we employed an mRNA-based protein replacement therapy. In this study, leveraging mRNA template design, structure-based screening identified NGFR100W …

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Author response for "Pain integration of multimodal noxious stimulation based on the perceptual instruction"

Yu Zhang, Yongkang Zhi, Qiushi Li, Ming Zhang et autres

Inhibition of α-synuclein aggregation by MCC950 attenuates dopaminergic neuronal damage in MN9D cells

Huiwen Gao, Mengfei Wang, Wen Li, Weihao Zheng et autres

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