Qin Liu

Tetrandrine-loaded manganese-doped ceria nanozyme for nebulized inhalation therapy of the ROS-driven inflammatory-fibrotic continuum

Qin Liu, Luo Yingli, Xueying Wang, Xiaoru Zhang et autres

Pulmonary fibrosis (PF) and acute lung injury (ALI) represent mechanistically interrelated stages along a shared inflammatory-fibrotic disease continuum, both driven by dysregulated macrophage responses and reactive oxygen species (ROS)-mediated signaling. Effective intervention requires a strategy that targets common upstream pathogenic drivers while …

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Toosendanin enhances endothelial repair and prevents inflammation via E2F1 mediated LINC01089

Yan Xiao, Qin Liu, Lili Chen, Chengcai Wen

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A real-world retrospective analysis to evaluate the efficacy and safety of surufatinib in the treatment of advanced neuroendocrine neoplasms in China

Shutong Liu, Yumeng Wang, Lianru Zhang, Baorui Liu et autres

Surufatinib, an oral vascular immune kinase inhibitor targeting angiogenesis and immune escape, is approved in China for the treatment of unresectable locally advanced or metastatic neuroendocrine tumors (NETs). This real-world study aimed to evaluate its efficacy and safety in neuroendocrine neoplasms (NENs), …

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Nanomaterial signatures program biomolecular condensates via triphasic separation for chemoplasticity remodeling

Liuting Zheng, Zengshuai Yan, Xinyue Li, Xiaoqi Tan et autres

Membraneless organelles form by phase separation and regulate cell behavior. We show that cholesterol-patterned AuNPs program nanomaterial-induced stress granules (NSGs) by lowering G3BP1 condensation barriers through a solid–liquid–liquid triphasic sequence: nanomaterials recruit hnRNPC, which then engages G3BP1 to nucleate gel-like condensates. We …

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Novel tetrameric bispecific KK-LC-1×CD16A-armed memory-like NK cells enhance antitumor efficacy in gastric cancer

Mengzhu Li, Tianran Chen, Siwen Wu, Yuxiang Li et autres

BACKGROUND: Cytokine-induced memory-like natural killer (CIML NK) cells demonstrate potent antitumor efficacy against hematological malignancies. Nevertheless, the therapeutic potential of adoptive NK cell transfer remains constrained in solid tumors due to insufficient tumor infiltration efficiency. Developing a novel tetravalent bispecific killer engager …

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Biomineralized engineered Lactococcus lactis-based in situ vaccination enhances antitumor immunity via sequential activation of chemo-immunotherapy

Ziqi Chen, Yaohua Ke, Junmeng Zhu, Lanqi Cen et autres

BACKGROUND: Combining chemotherapy with immunotherapy is a promising strategy to enhance in situ immunity by increasing antigen exposure and inflammation in the tumor microenvironment (TME). However, the inconvenience of separate administration and the randomness of delivery can diminish the synergistic effect of …

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Gut microbe-derived aromatic trace amines mediate individual variability in response to herbal medicine CDD-2101 for functional constipation

Shi-Fa Ruan, Yaqi Li, Ziwan Ning, Yicong Li et autres

Functional constipation (FC), a common gastrointestinal disorder, poses significant therapeutic challenges due to the limited efficacy and durability of current therapies. A novel strategy for addressing FC involves the targeting of gut dysbiosis. Our previous study demonstrated that the botanical drug CDD-2101 …

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An open-label single-center investigator-initiated exploratory clinical study in patients with refractory or recurrent solid tumors: R-ISV-FOLactis trial.

Rong Lv, Junmeng Zhu, Juanjuan Dai, Xiaolu Wang et autres

2640 Background: Soft tissue sarcomas (STSs) are a highly complex group of tumors and the treatment still remains a challenge. Immunotherapy has become a powerful clinical strategy, especially the application of therapeutic tumor vaccine. Hypofractionated radiotherapy (HFRT) can serve as an in …

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Bladder cancer biomarker analysis and drugtarget prediction based on pyroptosis-related genes

Ping Li, Xuexi Yang, Qin Liu, Hanchao Zhang et autres

BACKGROUND: Bladder cancer (BC) is a common and lethal condition that presents a considerable risk to public health. Studies have demonstrated that inflammation is pivotal in the onset and advancement of BC. Pyroptosis is a type of programmed cell death distinguished by …

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The therapeutic effect of thermo-sensitive hydrogel loaded with recombinant mycobacterium smegmatis expressing exogenous IL-15 in abdominal metastasis

Qingfei Wang, Yi Mei, Sen Hong, Aoxing Chen et autres

BACKGROUND: Tumor immunotherapy is one of the most promising strategies in cancer treatment. Specifically, intraperitoneal immunotherapy has emerged as a novel approach for dealing with abdominal metastases. Previously, we developed a genetically engineered strain of Mycobacterium smegmatis (Ms-IL15) that expresses the cytokine …

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750: EFFICACY, SAFETY AND MECHANISMS OF MAZIRENWAN GRANULES (MZRW, CDD-2101) ON FUNCTIONAL CONSTIPATION: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL WITH MULTI-OMICS AND MACHINE LEARNING ANALYSIS

Jingyuan Luo, Tao Wang, Xuanting Jiang, Wing Lam Wendy To et autres

Defining gastric cancer ecology: the crucial roles of TREM2+ macrophages and fibroblasts in tumor microenvironments

Qianqian Cao, Dianshui Sun, Can Tu, Jihua Wang et autres

Gastric cancer (GC) remains a major global health challenge, characterized by a complex tumor microenvironment (TME) that significantly influences disease progression and therapeutic outcomes. This study focuses on TREM2+ lipid-associated macrophages (LAM) and cancer-associated fibroblasts (CAFs) in modulating the GC microenvironment. Utilizing …

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