Accès ouvert
2026
article
OpenAlex
Wangbiao Wang, Diwen Zhu, Yifan Li, Areale Yeerjiang et autres
STMN1 is a critical microtubule-destabilizing protein that controls cell division and cytoskeleton dynamics and participates in tumor initiation and progression. Nevertheless, systematic pan-cancer research on its function, clinical significance and therapeutic value is still lacking. Herein, multi-omics data and bioinformatics methods were …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Yu Zheng, Lin Jiang, Liu Y, Xiao'e Jiang et autres
Abstract Background: Mild cognitive impairment (MCI) represents a high-risk prodromal stage of Alzheimer’s disease, and its prevalence and conversion risk are higher among community-dwelling older adults presenting with depressive symptoms. Currently, there is a lack of interpretable and easily implementable risk stratification …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Shuyi Xu, Hai Hu, Yifan Li, Jiawei Zhang et autres
Background: The efficacy of chemotherapy in triple-negative breast cancer (TNBC) is limited by intrinsic resistance and the tumor microenvironment (TME). Accumulating evidence reveals a mechanistic connection between programmed death-ligand 1 (PD-L1) and c-x-c motif chemokine receptor 4 (CXCR4), which dominate stroma barriers, …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Yiting Hou, Yifan Li, Cheng Chen, 玲汐 陈 et autres
ABSTRACT The morphological transition of fungi from vegetative hyphae to thick-walled chlamydospores enhances their longevity in harsh environmental conditions. Owing to this resilience, pathogenic fungi that form chlamydospores are particularly difficult to control. Therefore, understanding the mechanisms of chlamydospore formation is critically …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Shuo Liu, Yifan Li, Yiwen Zhang, Hao Zhou et autres
Abstract Photolysis plays a critical role in the elimination of herbicides in the environment. Butafenacil (BFA) is a protoporphyrinogen oxidase-inhibiting herbicide regarded as eco-friendly, but the toxicity of BFA photolysis products remains unclear. Natural light was found to enhance the degradation of …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Yuanchao Liu, Xinyu Shi, Yifan Li, Chenwei Wu et autres
In this paper, we reported a wild strain Z68, isolated from Tibet, was identified as Flammulina yunnanensis based on ITS sequence and phylogenetic analysis. Optimal condition for its mycelial growth (maltose, yeast extract, magnesium sulfate, 20 °C and pH 7.0–8.0) and fruiting …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Jingshun Zhang, Cui Zhang, Guopeng Jiang, Xi Liu et autres
Lung cancer is the leading cause of cancer-related mortality worldwide, with LUAD being characterized by high incidence and mortality rates. Despite the use of various treatments, including surgery, chemotherapy, immunotherapy, and molecular targeted therapy, the prognosis in LUAD patients remains unfavorable. As …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Yi-Xiang Wang, Shengqi Zheng, Xingzhou Guo, Zeyuan Song et autres
BACKGROUND Insulin resistance is associated with kidney stone risk, and estimated glucose disposal rate (eGDR) is a validated surrogate marker of insulin resistance. This study examined the association between eGDR and kidney stone prevalence. MATERIAL AND METHODS Data were derived from a …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ying Liu, Yufan Hao, Huiping Hu, Tianqiao Yong et autres
Ganoderma leucocontextum, a fungus discovered by our group, is highly valued for its immune modulation and anti-tumor polysaccharides significantly. Thus, this research aims to select a substrate formulation to enhance its polysaccharides and reveal the underlying mechanism. Seven distinct substrate formulations, incorporating …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
J Y Xiong, Jiake Zou, Xiao Deng, Dan Wang et autres
Gastrointestinal (GI) diseases are manifestations of abnormal brain-gut interactions, which are closely related to brain functions. Systematic sorting of the central mechanisms related to GI functions is of great clinical significance for preventing and treating GI disorders. We therefore conducted a literature …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Wenqi Pan, Lin Yang, Yu Zhang, Yuehua Chen et autres
Dysregulation of RNA m 6 A modification has been implicated in Alzheimer’s disease (AD), but the molecular mechanisms remain largely unclear. Here, we identified the presence of m 6 A on mitochondria-encoded messenger RNAs (mt-mRNAs) in the brain, with elevated levels correlated …
cn
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Hao Sun, Han Zs, Yuantao Qi, Yifan Li
Background Although dietary patterns have been increasingly linked to mental health, evidence regarding the cross-sectional association between overall diet quality and clinically relevant depressive symptoms remains inconsistent. We aimed to examine the association between the Healthy Eating Index-2015 (HEI-2015) and PHQ-9-defined clinically …
cn, gb
(code pays fourni par la source)