Shuang Li

Toward informed batch correction for single-cell transcriptome integration

Shuang Li, Malte D. Lücken, John C. Marioni, Sarah A. Teichmann et autres

gb, de, ca, us (code pays fourni par la source)

Thrombomodulin is essential for recombinant Fc-fusion protein production in Chinese hamster ovary cells via multiple signaling pathways

Xiaonan Ma, N Wang, Qihang Yan, Shuang Li et autres

BACKGROUND: Chinese hamster ovary (CHO) cells are the predominant cell line used for biotherapeutic production. To reduce the cost of therapeutic recombinant proteins produced in CHO cells, efforts have been made over decades to improve overall yield through media and process optimization, …

cn (code pays fourni par la source)

Autonomous Driving Behavior Decision-Making and Control Command Generation Based on Domain Generalization

Zhaoying Nie, Shuang Li, Chunsheng Liu

Traditional end-to-end autonomous driving algorithms often require training data and test data to have the same distribution, which is difficult to achieve in practical application scenarios, and often failing to achieve expected results when facing unfamiliar new environments. We propose a method …

cn (code pays fourni par la source)

Folic acid promotes myoblast migration through Folr1 interacting with RhoA and improves skeletal muscle regeneration

Shuang Li, Xin Wen, Huaixin Teng, Yunqin Yan et autres

Folic acid (FA) plays multiple roles in many biological processes. Myoblast intakes FA through endocytosis by folate receptor 1 (Folr1), which has vital role in regulating muscle development. However, the mechanism remains unclear. In this study, FA supplement experiment showed that FA …

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Vitamin A Promotes the Repair of Mice Skeletal Muscle Injury through RARα

Wenjia Zhang, Q. Peng, Xiaoyu Zhang, Jiaxu Guo et autres

Vitamin A (VitA) is an important fat-soluble vitamin which plays an important role in cell growth and individual development. However, the effect of VitA on the repair process of muscle injury and its molecular mechanism are still unclear. In this study, VitA …

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MiR-188-5p regulates the proliferation and differentiation of goat skeletal muscle satellite cells by targeting calcium/calmodulin dependent protein kinase II beta

Jing Jing, Sihuan Zhang, Jinbo Wei, Yuhang Yang et autres

OBJECTIVE: The aim of this study was to reveal the role and regulatory mechanism of miR-188-5p in the proliferation and differentiation of goat muscle satellite cells. METHODS: Goat skeletal muscle satellite cells isolated in the pre-laboratory were used as the test material. …

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Bioinformatics analysis of gene expression network regulation in osteogenic differentiation of human bone marrow mesenchymal stem cells RunningTitle: Bioinformatics analysis of osteogenic differentiation

Shuhong Zhang, Jingke Yao, Xiaoyuan Bai, Lihua Li et autres

Abstract Background:Among mesenchymal stem cells (MSCs), bone marrow mesenchymal stem cells (BMSCs) are considered the gold standard treatment for bone tissue regeneration. BMSCs have become an important cell source in bone and cartilage tissue engineering and regenerative medicine. However, the mechanism of …

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Isolation, culture and identification of sheep skeletal muscle satellite cells

Sailuo Wan, Qianqian Pan, Jinbo Wei, Cuiyun Zhu et autres

Skeletal muscle satellite cells (SMSCs) play an important role in muscle growth, regeneration and maintenance. This study aimed to isolate SMSCs from sheep, establish a system for isolation, culture and identification of SMSCs in vitro, and provide seed cells for subsequent studies. …

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TCP11L2 promotes bovine skeletal muscle‐derived satellite cell migration and differentiation via FMNL2

Shuang Li, Zhiqi Wang, Huili Tong, Shufeng Li

T-complex 11 like 2 (TCP11L2) is a protein containing a serine-rich region in its N-terminal region. However, the function of TCP11L2 is unclear. Here, we showed that TCP11L2 expression gradually increased during muscle-derived satellite cell (MDSC) differentiation in vitro, reaching a peak …

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Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase

Zhao Wang, Zhiqi Wang, Yusheng Pang, Huili Tong et autres

FNDC4 is an anti-inflammatory factor that alters the activation state of macrophages; it is used to treat colitis in mice. However, its role in muscle formation and mechanism of function remains unknown. We found that FNDC4 promotes the bovine MDSCs migration and …

cn, us, nl, gb (code pays fourni par la source)

Podocan Promotes Differentiation of Bovine Skeletal Muscle Satellite Cells by Regulating the Wnt4-β-Catenin Signaling Pathway

Shuang Li, Dan Liu, Yuying Fu, Chunyu Zhang et autres

BACKGROUND: Small leucine-rich repeat proteins (SLRPs) are highly effective and selective modulators of cell proliferation and differentiation. Podocan is a newly discovered member of the SLRP family. Its potential roles in the differentiation of bovine muscle-derived satellite cells (MDSCs) and its underlying …

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WDR13 promotes the differentiation of bovine skeletal muscle‐derived satellite cells by affecting PI3K/AKT signaling

Yuying Fu, Shuang Li, Huili Tong, Shufeng Li et autres

Muscle satellite cells are usually at rest, and when externally stimulated or regulated, they can be further differentiated by cell fusion to form new myotubes and muscle fibers. WD repeat domain 13 (WDR13) is highly conserved in vertebrates. Studies have shown that …

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