Shuang Li

Sampling Complexity of TD and PPO in RKHS

Lu Zou, Weizhong Zhang, Liang Ding, Shuang Li

We revisit Proximal Policy Optimization (PPO) from a function-space perspective. Our analysis decouples policy evaluation and improvement in a reproducing kernel Hilbert space (RKHS): (i) A kernelized temporal-difference (TD) critic performs efficient RKHS-gradient updates using only one-step state-action transition samples; (ii) a …

An Assessment of the Effective Pollination Period and Its Main Limiting Factor in Wurfbainia villosa var. villosa (Lour.) Škorničk. & A. D. Poulsen (Zingiberaceae)

Qianxia Li, Yanqian Wang, Ge Li, Shuang Li et autres

Low fruit set in Wurfbainia villosa var. villosa has been a major constraint in its cultivation, with the effective pollination period (EPP) identified as a key factor. In this study, the EPP was assessed for the first time by examining stigma receptivity, …

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Mesenchymal stem cell-derived extracellular vesicles: current advances in preparation and therapeutic applications for neurological disorders

Shuang Li, Jiayi Zhang, Luyao Sun, Ze Yang et autres

Extracellular vesicles (EVs), nanoscale vesicles released by various cell types, have garnered significant attention in regenerative medicine. Mesenchymal stem cell-derived EVs (MSC-EVs) exhibit unique advantages, including their compact size, ability to traverse the blood-brain barrier (BBB), low immunogenicity, and high biosafety profile. …

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Netrin-1 promotes pancreatic tumorigenesis and innervation through NEO1

Yosuke Ochiai, Hiroki Kobayashi, Masaki Sunagawa, Taisuke Baba et autres

Abstract Nerves have been shown to regulate cancer progression. However, a clear demonstration of a role for axon guidance molecules in pancreatic tumorigenesis, innervation, and metastasis has been lacking. Using murine Kras G12D -mutant pancreatic organoids, we screened axon guidance molecules by …

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Neutrophil Extracellular Traps Promote AIM2-Dependent Microglial Pyroptosis Following Stroke.

Hanze Chen, Linhui Ni, Jinhua Zhang, Xu Zheng et autres

). In a murine stroke model, NETs were detected in the brain parenchyma. Pharmacological inhibition of NET formation with GSK484, a selective protein-arginine deiminase type 4 antagonist, suppressed NET production, reduced absent in melanoma 2 (AIM2) inflammasome expression, and improved neurological outcomes …

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Recent Advances in Comorbidities of Psychogenic Non-Epileptic Seizures.

Shuang Li, Jianhua Zhang

Psychogenic non-epileptic seizures are accompanied by motor,behavioral,sensory,and/or cognitive changes,with the clinical manifestations similar to epileptic seizures.This disease is easy to be misdiagnosed and neglected in clinical work.At present,most intervention measures still depend on the experience of clinicians.This article reviews the comorbidities of …

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miR-103 promotes esophageal squamous cell carcinoma metastasis by targeting FOXP1

Min Huang, Jun Cai, Hai Zeng, Yan Zhu et autres

Esophageal squamous cell carcinoma (ESCC), a prevalent malignancy within the digestive tract, is associated with a significantly high mortality rate. MicroRNAs were already demonstrated to work in a wide range of tumors. The objective of the present research was to elucidate the …

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Quaternary ammonium surfmers: synthesis, characterization and antibacterial performance

Cailing Li, Shixin Xie, Shuang Li, Dinghua Yu

As the length of the hydrophobic chain of the surfactant increases, the antibacterial performance of the four quaternary ammonium cationic surfactant monomers shows an increasing trend.

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OONO− reduces the expression of steroidogenic genes and proteins to inhibit estrogen secretion in porcine ovarian granulosa cells

Yue Zhang, Kun Lei, Zhe Wang, Fang Zhao et autres

Granulosa cells (GCs), as critical somatic components of ovarian follicles, maintain female reproductive physiology through steroid hormone regulation and follicular development. To investigate the effects of the peroxynitrite anion (OONO−) on GCs' function and estrogen (E2) secretion in sows, GCs were treated …

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RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway

Qiangping Wang, Shuang Li, Wenjie Wu, Wenke Zhou et autres

BACKGROUND: Cerebral ischemia/reperfusion injury (CIRI), a common, universal clinical problem that costs a large proportion of the economic and disease burden. Identifying the key regulators of cerebral I/R injury could provide potential strategies for clinically improving the prognosis of stroke. Ring finger …

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Primary adenoid cystic carcinoma of the rib with metastases: A rare case report and literature review

Shuang Li, Rong Fan, Shuying Luo, Kaiyuan Jin et autres

Adenoid cystic carcinoma (ACC) is a rare and aggressive malignant tumour predominantly found in the salivary glands but can also occur elsewhere. Primary ACC in the bones is particularly rare, with most reports focusing on cases of ACC in the maxilla and …

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miR-485-5p acts as a negative regulator of sepsis-associated acute kidney injury through targeting ICAM-1

Rui Wang, Yongheng Wang, Shuang Li, Yu Zhang et autres

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