Qiushi Wang

Low serum complement C3 levels are associated with all-cause mortality in Chinese centenarians: a prospective cohort study

Weiguang Zhang, Yuting Duan, Zhe Li, Miaomiao Liu et autres

Background The complement system plays an important role in innate immunity and age-related inflammation, but its prognostic value in centenarians remains unclear. This study aimed to examine the associations between serum complement C3 and C4 levels and all-cause mortality among centenarians. Methods …

cn, ph (code pays fourni par la source)

Testosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study

Zehao Zhang, Xiaowei Cheng, Zeyu Qu, Yue Niu et autres

BACKGROUND: The relationship between kidney function and mortality in centenarians, particularly with respect to hormonal regulation, remains unclear. This study investigated the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in female centenarians and explored the potential role of testosterone. …

cn (code pays fourni par la source)

Assessment of the effectiveness of art drawing for children with ASD and prediction of risk factors

Jinghong Yao, Qiushi Wang, Yang Qiao, Ying Bo Cai et autres

Autism spectrum disorder (ASD) is a recognized public health issue with unknown origins. This study explored the use of art therapy to address anxiety and behavioral issues in ASD, focusing on individualized treatment and multi-method assessment. A total of 131 children with …

cn, mo (code pays fourni par la source)

Additional file 1 of Testosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study

Zehao Zhang, Xiaowei Cheng, Zeyu Qu, Yue Niu et autres

Supplementary Material 1.

cn (code pays fourni par la source)

Additional file 1 of Testosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study

Zehao Zhang, Xiaowei Cheng, Zeyu Qu, Yue Niu et autres

Supplementary Material 1.

cn (code pays fourni par la source)

Integrating Network Pharmacology, Machine Learning, and Experimental Validation to Elucidate the Mechanism of Cardamonin in Treating Idiopathic Pulmonary Fibrosis

Wenyue Zhang, Yi Maggie Guo, Qiushi Wang, Kai Wang et autres

Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible interstitial lung disease characterized by progressive scarring of the lungs. The available therapeutic strategies are limited and primarily focus on slowing disease progression rather than achieving fibrosis reversal. Cardamonin (CDN), a food-derived natural …

cn (code pays fourni par la source)

Melatonergic Regulation of Polyethism and Circadian Foraging in Apis mellifera

Naznin Nahar, Quynh Tranthi, Jadwiga Bembenek, Ahmed A. M. Mohamed et autres

Melatonin is a conserved indolamine implicated in circadian and developmental timing, but its role in social-insect task allocation is unclear. Here, we show that melatonergic signaling modulates the nurse → forager transition in the honey bee (Apis mellifera). A single hemocoelic dose …

bd, jp, Égypte, sa (code pays fourni par la source)

Polycomb Repressive Complex 1 and USP16 localize to the mitochondrion and influence its function

Lei Shi, Chunxu Chen, Xiaokun Jian, Qiushi Wang et autres

Polycomb Repressive Complex 1 (PRC1) represses gene expression by ubiquitinating histone H2A or physically compacting chromatin. USP16, one of the histone H2A deubiquitinases, antagonizes PRC1-mediated H2A ubiquitination (H2Aub). Here, we report that both PRC1 and USP16 are also localized in mitochondria and …

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Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians

Yuting Duan, Zhe Li, Weiguang Zhang, Yue Niu et autres

The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and all-cause mortality. …

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The updated evidence of pirfenidone treated silicosis based on network pharmacology, molecular docking and experimental validation

Sirong Chang, Shengpeng Wen, Wenyue Zhang, Huang-Fan Zhang et autres

Objective: Silicosis remains a debilitating occupational lung disease with limited therapeutic options, despite emerging evidence supporting pirfenidone's (PFD) anti-fibrotic efficacy in clinical practice. However, the molecular circuitry governing PFD's therapeutic actions in silicosis remains incompletely mapped, hindering mechanism-driven therapeutic optimization. To bridge …

cn (code pays fourni par la source)

Abstract 3487: Mechanistic role of CD70 in UV exposed keratinocytes and cutaneous squamous cell carcinoma (cSCC)

Asad Ullah Khan, Qiushi Wang, Chengcheng Hu, Emanuel Petricoin et autres

The incidence of cutaneous squamous cell carcinoma (cSCC) is rising due to limited prevention strategies. Significant gaps persist in understanding the mechanisms of UV-induced DNA damage and immune modulation in skin cancer development. By analyzing expression data from sun-exposed and sun-protected skin …

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Preference-Oriented Supervised Fine-Tuning: Favoring Target Model over Aligned Large Language Models

Yuchen Fan, Yuzhong Hong, Qiushi Wang, Junwei Bao et autres

Alignment, endowing a pre-trained Large language model (LLM) with the ability to follow instructions, is crucial for its real-world applications. Conventional supervised fine-tuning (SFT) methods formalize it as causal language modeling typically with a cross-entropy objective, requiring a large amount of high-quality …