Low serum complement C3 levels are associated with all-cause mortality in Chinese centenarians: a prospective cohort study
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Le résumé fourni par la source
Background The complement system plays an important role in innate immunity and age-related inflammation, but its prognostic value in centenarians remains unclear. This study aimed to examine the associations between serum complement C3 and C4 levels and all-cause mortality among centenarians. Methods We studied centenarians in Hainan Island, China. We used multivariable-adjusted restricted cubic splines, Cox proportional hazards models, and Kaplan–Meier survival analysis to assess the relationships between serum C3 and C4 levels and all-cause mortality. Results A total of 906 centenarians were included in the final analysis. During a median follow-up of 30.1 months, 838 (92.5%) participants died. There was a significant inverse linear relationship between serum C3 levels and all-cause mortality ( P = 0.031). Compared with the highest C3 quartile (Q4), individuals in the lowest quartile (Q1) had an increased risk of all-cause mortality (hazard ratio = 1.337; 95% confidence interval: 1.092–1.635; P = 0.005), whereas C4 levels showed no significant relationship with mortality ( P > 0.05). When we used Q1 (0.86 g/L) as a cut-off, centenarians with C3 levels below this threshold also showed a higher mortality risk than those above this threshold (hazard ratio = 1.250; 95% confidence interval: 1.063–1.470; P = 0.007). A Kaplan–Meier analysis further indicated a shorter survival time in the lowest C3 quartile (Q1 vs. Q4: 26 vs. 34 months, P = 0.002). In contrast, C4 levels were not significantly associated with survival. Conclusion Serum complement C3 levels, but not C4 levels, might be associated with the risk of all-cause mortality in centenarians. However, because all centenarians were recruited from Hainan Island, external validation in other regions and ethnic populations is warranted.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Low serum complement C3 levels are associated with all-cause mortality in Chinese centenarians: a prospective cohort study
- Date Crossref
- 09/09/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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State Administration of Traditional Chinese Medicine of the People's Republic of China pays non établi dans la noticeOrganisme public
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Hainan General Hospital pays non établi dans la noticeÉtablissement de santé
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Qingdao University Department of Geriatric Medicine pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Qingdao University pays non établi dans la noticeÉtablissement de santé
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Henan University of Science and Technology Luoyang Key Laboratory of Clinical Multiomics and Translational Medicine pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Henan University of Science and Technology pays non établi dans la noticeÉtablissement de santé
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Chinese General Hospital College of Nursing and Liberal Arts pays non établi dans la noticeÉtablissement de santé
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Chinese PLA General Hospital Department of Nephrology pays non établi dans la noticeÉtablissement de santé
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Southern Medical University pays non établi dans la noticeUniversité ou école supérieure
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Hainan Medical University pays non établi dans la noticeUniversité ou école supérieure
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Department of Laboratory Medicine pays non établi dans la noticeStructure de recherche
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Central Laboratory pays non établi dans la noticeStructure de recherche
State Administration of Traditional Chinese Medicine of the People's Republic of China, Hainan General Hospital et Department of Geriatric Medicine — Qingdao University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.