Jia Liu

The R2R3-MYB transcription factor ScMYB20 negatively regulates drought and salt tolerance through a dual-repression of ScCHALCONE SYNTHASE-1 (ScCHS1) -mediated flavonoid biosynthesis in the desert moss Syntrichia caninervis

Jiangyuan Xiao, Yan Liang, Jia Liu, Minghui Yang et autres

The desert moss Syntrichia caninervis is one of the most desiccation-tolerant land plants known and provides a powerful system for dissecting the molecular foundations of extreme stress adaptation in early-diverging land lineages. The MYB transcription factor superfamily orchestrates secondary metabolism and stress …

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Genome-wide analysis of the 1R-MYB family in Syntrichia caninervis reveals ScMYB24 as a negative regulator of abiotic stress tolerance

Jiangyuan Xiao, Minghui Yang, Jia Liu, Yan Liang et autres

Syntrichia caninervis , an extremotolerant desert moss, serves as an ideal model for studying abiotic stress tolerance mechanisms. The 1R-MYB transcription factors (TFs) are crucial in various biological processes and stress responses, yet their roles in S. caninervis remain poorly understood. Here, …

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Human adenovirus protein VII inhibits type I IFN production by antagonizing viral RNA sensor RIG-I

Pei-hong Yu, Li-min Zhang, Qian Gu, Jia Liu

The genomes of human adenoviruses (HAdVs) are double-stranded DNA bound with viral nucleocapsid protein VII. During HAdV infection, host RNA polymerase can produce viral-associated RNAs (VA RNAs) that are recognized by retinoic acid-inducible gene I (RIG-I). However, it remains unclear whether and …

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Genome-wide identification of the chickpea chitinase family reveals CaCHI4, a Class IV chitinase, as a positive regulator of salt tolerance

Yan Liang, Chaoni Liang, Fanzhen Fei, Jia Liu et autres

Chickpea ( Cicer arietinum L.) is a vital legume crop, yet its productivity is severely constrained by soil salinity. While chitinases (CHIs) are well-recognized for their roles in biotic defense, their involvement in abiotic stress adaptation remains largely unexplored in chickpea. In …

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pH Modulation as a Key Strategy for Developing a Stable Lyotropic Liquid Crystal Formulation of Octreotide Acetate

Yingshun Xin, Shupei Yang, Chan Li, Chang Li et autres

Background: Lyotropic liquid crystal (LLC) systems provide sustained release and convenient administration for peptide delivery. Octreotide, a first-line somatostatin analogue, has previously been formulated into LLC systems mainly using the hydrochloride salt. Here, we investigated the acetate salt, which is widely used …

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Application of deep learning technology in breast cancer: a systematic review of segmentation, detection, and classification approaches

Shuo Gao, Jia Liu, Linqian Li, Di Yang et autres

OBJECTIVE: To provide a critical and clinically oriented synthesis of recent deep learning developments for breast cancer imaging across major modalities, with emphasis on model architectures, dataset characteristics, methodological quality, and implications for clinical translation. METHODS: Following PRISMA guidelines, we systematically searched …

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Observation of Quantum-Criticality-Class Crossover at the LaAlO 3 / KTaO 3 (111) Interface

Jia Liu, Long Cheng, Junkun Zha, Fei Ye et autres

In the two-dimensional (2D) limit, the quantum fluctuation is significantly enhanced which could induce a quantum phase transition. Investigating the quantum criticality is an effective approach to elucidate the underlying physics of 2D superconductivity. Here we report the observation of different universality …

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Mussel Inspired Hydrogel Promotes Axon Regeneration via Piezo1 Modulation and Cytoskeleton Dynamics in Synergy After Spinal Cord Injury

Genjiang Zheng, Chen Yang, Wei Yu, Ye Edward Tian et autres

Abstract Paralysis resulting from spinal cord injury (SCI) arises from the limited regenerative capacity of axons. Mechanical factors have recently emerged as crucial regulators of axon regeneration, complementing or even surpassing chemical cues. In this study, we demonstrated that extracellular matrix stiffness, …

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Natural Spore and Pollen Microcarriers: Processing and Advanced Drug Delivery

Jia Liu, Jingjing Wang

Spores and pollen, as ubiquitous organisms found in nature, possess a remarkable core-shell structure and intricate surface morphology. These tiny particles are notable for their dimensional uniformity, sustainable utilization, environmental friendliness, porosity, amphiphilicity, and strong adhesive properties. In addition, they display excellent …

Advances in the Study of Polymorphisms of ADRA2A Gene Related to Motion Sickness in Human-Machine Environment

Jingyu Mao, Shuo Li, Jia Liu, Di Qin et autres

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CRISPR/Cas9-mediated editing of uORFs in the BnVTC2 facilitates abiotic stress resilience without yield penalty

Mengyu Hao, Yilin Li, Shifei Sang, Yunfei Wen et autres

Upstream open reading frame (uORF)-based genetic engineering has emerged as an excellent strategy for improving agronomic traits of crops. Despite its significant potential, the exploration of CRISPR/Cas-based uORF engineering in many crop species remains unexplored, thereby limiting the application of this approach …

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Understanding the stability landscape of LbCas12a by deep analysis of stabilizing mutations and mutation combinations

Jiajun Dong, Shaojie Wang, Wenxue Xu, Jia Liu

Abstract Cas12a is one of the most widely used Cas nucleases for genome editing and in vitro diagnosis. A number of engineered Cas12a mutants have been identified with improved activity and stability. However, it remains largely unaddressed how these mutations interact. In …

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