Lin Wang

Implicating a functional domain (SPOC) of RBM15 in the pathogenesis of RBM15::MKL1 fusion protein-induced acute megakaryoblastic leukemia

Amos Espinosa, Madeline Y. Mayday, Chen Mi, Lin Wang et autres

Abstract In acute megakaryoblastic leukemia (AMKL), immature megakaryoblasts accumulate due to excessive proliferation and failure to terminally differentiate. AMKL represents roughly 10% of pediatric AML and carries a poor prognosis despite aggressive treatment. A recurrent cytogenetic alteration found in a subset of …

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Robotic-assisted thoracoscopic surgery for esophageal duplication cyst in a child: a rare case report and literature insight

Boshen Shu, Shufeng Zhang, Jian Gao, Lin Wang et autres

Introduction: Esophageal duplication cyst (EDC) is a rare congenital anomaly originating from the embryonic foregut. While often asymptomatic, it can present with respiratory symptoms due to compression. We report a rare pediatric case successfully managed using robotic-assisted thoracoscopic surgery (RATS), highlighting the …

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Re: Guohua Zeng, Kehua Jiang, Shusheng Liu, et al. Flexible Ureteroscopy with a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2–3 cm Renal Stones: An International, Multicenter, Randomized, Noninferiority Trial. Eur Urol. 2026;89:45–54

Youyi Lu, Lin Wang, Jitao Wu

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Da Vinci robotic assisted pyeloplasty versus laparoscopic pyeloplasty in newborns under 3 months

Boshen Shu, Shufeng Zhang, Jianxi Gao, Lin Wang et autres

Ureteropelvic junction obstruction (UPJO) is a common cause of hydronephrosis in children. We aimed to investigate the efficacy of robotic-assisted laparoscopic pyeloplasty (RALP) in newborns with UPJO compared to laparoscopic pyeloplasty (LP). We conducted a retrospective study of newborns aged ≤ 3 …

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Robotic-assisted pyeloplasty in a five-day-old infant with severely infected hydronephrosis: The very young case report and review of literature

Boshen Shu, Shufeng Zhang, Jian Gao, Lin Wang et autres

INTRODUCTION: Postnatal management of newborns with antenatal hydronephrosis remains controversy. Most of the newborns with antenatal hydronephrosis are asymptomatic with only rare ones who develop renal insufficiency. We described a pediatric robotic assisted pyeloplasty for treating a five-day-old infant, who was diagnosed …

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RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation

Madeline Y. Mayday, Giulia Biancon, Manyi Wei, Christian Ramirez et autres

ABSTRACT: The recurrent t(1;22) translocation in acute megakaryoblastic leukemia (AMKL) encodes the RBM15-MKL1 fusion protein. Dysregulation of the N6-methyladenosine (m6A) modification affects RNA fate and is linked to oncogenesis. Because RBM15 is critical for bringing the m6A writer complex to specific RNAs, …

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Safety and efficacy of robotic-assisted laparoscopic pyeloplasty for ureteropelvic junction obstruction in infants under 6 months

Jianxi Gao, Shufeng Zhang, Lin Wang, Xiaohui Wang

To evaluate the safety and efficacy of robotic-assisted laparoscopic pyeloplasty (RALP) in infants under 6 months of age with ureteropelvic junction obstruction (UPJO). A retrospective analysis was conducted on infants aged ≤ 6 months who underwent RALP for UPJO between March 2021 …

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1306 Clinical Validation of a Novel Comprehensive Next Generation Sequencing Assay for Hematolymphoid Malignancies

Lin Wang, Lanie E. Happ, Kemin Xu, Kenneth Ofori et autres

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Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium‐Doped Nanosystem to Enhance Chemotherapy and Immunotherapy

Qian Cheng, Yuzhe Chen, Danyi Zou, Qilin Li et autres

The anti-tumor efficacy of current pharmacotherapy is severely hampered due to the adaptive evolution of tumors, urgently needing effective therapeutic strategies capable of breaking such adaptability. Metabolic reprogramming, as an adaptive survival mechanism, is closely related to therapy resistance of tumors. Colorectal …

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Venetoclax-based therapy for relapsed or refractory acute myeloid leukemia: latest updates from the 2023 ASH annual meeting

Xubo Gong, Xin He, Lin Wang, Teng Yu et autres

Patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) often exhibit limited responses to traditional chemotherapy, resulting in poor prognosis. The combination of venetoclax (VEN) with hypomethylating agents has been established as the standard treatment for elderly or medically unfit AML …

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P121: Myeloid neoplasms with the t(3;12)(q26.2;p13)/MECOM-ETV6 translocation: Report of two new cases and review of the literature

Soumya Mikkilineni, Juan Pineda-Reyes, Lin Wang, Dorothy Foster et autres

The MECOM (MDS1 and EVI1 complex locus) gene is located at 3q26.2, encoding a proto-oncogenic transcription factor involved in the RAS/receptor tyrosine kinase pathway. Rearrangements involving MECOM/3q26.2, such as inversion, translocation, insertion and cryptic chromosomal changes, have been observed in acute myeloid …

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Venetoclax-based therapy for relapsed or refractory acute myeloid leukemia: latest updates from the 2022 ASH annual meeting

Xubo Gong, Yi Zhang, Xin He, Milad Moloudizargari et autres

Venetoclax (VEN), the first selective Bcl-2 inhibitor, has shown efficacy and safety both as monotherapy and in combination with other agents in the treatment of newly diagnosed acute myeloid leukemia (AML), while its role in relapsed or refractory (R/R) disease is not …

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