Na Liu

Diagnosis, treatment, and monitoring of cytomegalovirus pneumonia in a hematopoietic stem cell transplantation child

Xuan Fan, Chaonan Li, Hui Zhao, Na Liu et autres

Background: Cytomegalovirus (CMV), an opportunistic pathogen, can cause severe pneumonia in Chronic myeloid leukemia (CML) children undergoing hematopoietic stem cell transplantation (HSCT), resulting in a high mortality rate. Case presentation: An 11-year-old girl was hospitalized with a 3-day history of fever and …

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Efficacy and safety of immune checkpoint inhibitors for advanced squamous non-small cell lung cancer: a systematic review and network meta-analysis

Na Liu, Baowanze Zhang, Jiali He, Li Su

Objective: Significant efficacy heterogeneity exists between first- and second-line immunotherapy regimens for advanced squamous non-small cell lung cancer (SqNSCLC), but most regimens lack directly comparable clinical trial evidence, resulting in unclear prioritization. This analysis identifies optimal treatment strategies by evaluating differences in …

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ARHGAP11A is a potential prognostic biomarker and therapeutic target for pancreatic adenocarcinoma

Xindi Huang, Jian Wu, Yalan Wang, Jingping Yu et autres

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PHF6 maintains acute myeloid leukemia via regulating NF-κB signaling pathway

Shuaibing Hou, Xiaomin Wang, Tengxiao Guo, Yanjie Lan et autres

Acute myeloid leukemia (AML) is a major hematopoietic malignancy characterized by the accumulation of immature and abnormally differentiated myeloid cells in bone marrow. Here with in vivo and in vitro models, we demonstrate that the Plant homeodomain finger gene 6 (PHF6) plays …

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[Efficacy and Safety of Allogeneic Hematopoietic Stem Cell Transplantation with Decitabine-containing Regimen in Myelodysplastic Syndromes and Myelodysplastic Syndromes Transformed Acute Myeloid Leukemia].

Yuxin Wang, Yao Sun, Jing Xie, Na Liu et autres

OBJECTIVE: To evaluate the efficacy and safety of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with decitabine (Dec)-conditioning regimen in the treatment of myelodysplastic syndrome (MDS) and MDS transformed acute myeloid leukemia (MDS-AML). METHODS: /d×3 d). RESULTS: =0.019). CONCLUSION: Allo-HSCT with Dec-conditioning regimen …

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Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

Cheng-Long Hu, Bingyi Chen, Zijuan Li, Tianbiao Yang et autres

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic regulator that recruits DNMT1 to methylate DNA, is highly expressed in AML and predicts poor prognosis. UHRF1 is required for myeloid leukemogenesis …

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PHF6 maintains acute myeloid leukemia via regulating NF-kB signaling pathway

Weiping Yuan, Shuaibing Hou, Xiaomin Wang, Tengxiao Guo et autres

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A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation

Yifan Zhang, Chunhui Xu, Na Liu, Ling Zhang et autres

The ETO-family transcriptional corepressors, including ETO, ETO2, and MTGR1, are all involved in leukemia-causing chromosomal translocations. In every case, an ETO-family corepressor acquires a DNA-binding domain (DBD) to form a typical transcription factor-the DBD binds to DNA, while the ETO moiety manifests …

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Real-time detection of viruses in aerosols with weak light imaging based on Tesla discharge

Zuxin Li, Chengming Xia, Yi Tian, Beilei Zhang et autres

The analysis and detection of nucleic acid and specific antigens and antibodies are the most basic technologies for virus monitoring. However, the potential window for applying these technologies exists within a late specific period in the early monitoring and control of unknown …

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Allogeneic haematopoietic stem cell transplantation with decitabine-containing preconditioning regimen in TP53-mutant myelodysplastic syndromes: A case study

Yuxin Wang, Yao Sun, Jing Xie, Jiangwei Hu et autres

Myelodysplastic syndrome (MDS) with TP53 mutations has a poor prognosis after transplantation, and novel therapeutic means are urgently needed. Decitabine (Dec) monotherapy has demonstrated improved overall response rates in MDS and acute myeloid leukaemia, although these responses were not durable. This study …

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Dietary ω-3 fatty acids reduced atrial fibrillation vulnerability via attenuating myocardial endoplasmic reticulum stress and inflammation in a canine model of atrial fibrillation

Tao Tu, Biao Li, Xuping Li, Baojian Zhang et autres

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A Retrospective Observation of Treatment Outcomes Using Decitabine-Combined Standard Conditioning Regimens Before Transplantation in Patients With Relapsed or Refractory Acute Myeloid Leukemia

Yuhang Li, Longcan Cheng, Xu Chen, Jianlin Chen et autres

Hypomethylating agents, decitabine (DAC) and azacitidine, can act as prophylactic and pre-emptive approaches after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and a non-intensive bridging approach before allo-HSCT. However, they are rarely used as a part of conditioning regimens in patients with relapsed …

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