Erwei Sun

Reliability and Validity of the Systemic Lupus Erythematosus Symptom Checklist in Chinese Systemic Lupus Erythematosus Patients

Jiaying Chen, Liuyuan Zhang, Zhaorong Huang, Long Zhang et autres

Background/Aims: The purpose of this research was to translate and culturally adapt the Systemic Lupus Erythematosus Symptom Checklist (SSC) and evaluate its reliability and validity in Chinese systemic lupus erythematosus (SLE) patients. Materials and Methods: The development of the Chinese version of …

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Association between the CRP–TyG index and lupus nephritis risk

Baozhu Liang, Ming Tang, Junqi Huang, Yingfei Li et autres

Assessment of insulin resistance is increasingly emphasized in patients with systemic lupus erythematosus (SLE) due to its significant role in predicting kidney injury and cardiovascular risk. Given that sustained inflammation is a hallmark of SLE, the novel C-reactive protein (CRP)-triglyceride-glucose (TyG) index …

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Summary of best evidence on self-management in adult patients with systemic lupus erythematosus

Zhaorong Huang, Erwei Sun

ObjectiveTo evaluate and summarize the best evidence on self-management in adult patients with systemic lupus erythematosus (SLE) and provide evidence-based recommendations in clinical settings.MethodsLiteratures related to self-management of SLE patients were searched in the guideline websites, professional association websites and relevant databases, …

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Biomimetic bioreactor for potentiated uricase replacement therapy in hyperuricemia and gout

Bin Yang, Guihu Luo, Zhenglan Ban, Quanxin Ning et autres

Introduction Uricase replacement therapy is a promising approach for managing hyperuricemia and gout but is hindered by challenges such as short blood circulation time, reduced catalytic activity, and excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies to enhance therapeutic efficacy …

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GPX4 mRNA levels in the polymorphonuclear neutrophils are negatively correlated with autoantibody production, disease activity, and lupus alopecia in systemic lupus erythematosus

Liuying Li, Fangyuan Yang, Huijuan Liu, Ruilin Zhang et autres

Abstract Background Ferroptosis is a type of regulated necrosis and glutathione peroxidase 4 (GPX4) has been recognized as a key enzyme that protects against ferroptosis. However, the significance of GPX4 in polymorphonuclear neutrophils (PMNs) of systemic lupus erythematosus (SLE) has not been …

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Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammation

Yingfei Li, Yi He, Fangyuan Yang, Rongmei Liang et autres

BACKGROUND: Psoriasis is a common chronic inflammatory disease with an unclear aetiology. Keratinocytes in psoriasis are susceptible to exogenous triggers that induce inflammatory cell death. OBJECTIVES: To investigate whether gasdermin E (GSDME)-mediated pyroptosis in keratinocytes contributes to the pathogenesis of psoriasis. METHODS: …

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Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus

Zhongzhen Li, Zhiwei Lei, Wanying Yang, Chunxia Jing et autres

Abstract Background Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by the presence of numerous autoantibodies. The interaction of infectious agents (viruses, bacteria and parasites) and a genetically susceptible host may be a key mechanism for SLE. Toxoplasma gondii …

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Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson et autres

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GPX4 mRNA levels in the PMNs are negatively correlated with autoantibody production, disease activity and lupus alopecia in SLE

Fangyuan Yang, Liuying Li, Huijuan Liu, Ruilin Zhang et autres

Abstract Background: Ferroptosis is a recently discovered type of regulated necrosis and glutathione peroxidase 4 (GPX4) has been recognized as a key enzyme that protects against ferroptosis. However, the significance of GPX4 inPolymorphonuclear neutrophils (PMNs) ofsystemic lupus erythematosus (SLE) has not been …

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Efficacy and Safety of CMAB008 Compared with Innovator Infliximab in Patients with Moderate-to-Severe Rheumatoid Arthritis Receiving Concomitant Methotrexate: A Randomized, Double-blind, Multi-center, Phase III Non-inferiority Study

Hua Ye, Shengyun Liu, Jian Xu, Kexia Chai et autres

OBJECTIVES: The aim of this work is to verify the non-inferior efficacy and safety of CMAB008 compared with innovator infliximab in rheumatoid arthritis patients combined with methotrexate. METHODS: We conducted a randomized, double-blinded, parallel, positive control design, multicenter study, with a stable …

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Downregulation of Sox8 mediates monosodium urate crystal-induced autophagic impairment of cartilage in gout arthritis

Lu Xiao, Shudian Lin, Wenchao Xu, Erwei Sun

The deposition of monosodium urate (MSU) crystals in arthritic joints of gout seriously damages cartilage. This study aimed to investigate whether MSU crystal-induced cartilage impairment was related to autophagic signaling. mRNAs of cartilage from MSU-induced gouty arthritis rat model were sequenced. MSU …

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Single-Cell Analysis of Patients with Axial Spondyloarthritis After Anti-TNFα Treatment: Experimental Data and Review of the Literature

Zhibin Zhao, Zhen-Hua Bian, Zhangmei Lin, Shu-Fan Wu et autres

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