Xiao Li

Anti-Trop2-Guided Liposomes Restore Methotrexate Sensitivity in Chemoresistant Gestational Trophoblastic Neoplasia

Rong Wang, Weidong Fei, Jiale Qin, Mengxia Zheng et autres

Purpose: Methotrexate (MTX) resistance limits its clinical efficacy in gestational trophoblastic neoplasia (GTN). To develop safer treatment strategies for patients of reproductive age, this study aims to investigate whether anti-trophoblast cell surface antigen 2 (Anti-Trop2) facilitates the tumor-targeted delivery of MTX-loaded liposomes, …

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Comparative Risk of Stroke Associated with Active Smoking in Chinese and Asian Populations.

Ze Min Cai, Xia Guo, Xi Zhang, Dan Ying Li et autres

Objective: ) of smoking-attributed stroke among the Chinese and Asian populations. Methods: A literature search was conducted from the inception to September 10, 2022. Studies meeting the criteria were included. The articles were screened, and related information was extracted. Pooled RRs stratified …

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Disparity in Mpox awareness and vaccine hesitancy: a cross-sectional study of 3,483 university students in Northwest China

Ying Zhang, Jun Gan, Dong Miao, Xiao Li et autres

Background Mpox has shown a westward spreading trend in China and university students are a high-risk group. This study aimed to assess the current status of Mpox-related knowledge, attitudes, vaccination willingness, and associated factors among college students in northwestern China, so as …

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A One‐Two Punch Strategy Against Cancer: Simultaneously Inducing and Eliminating Senescent Tumor Cells

Bo Fang, Fei Pan, Sailing Chen, Wenli Tian et autres

Abstract Senolytics, an emerging class of agents that selectively deplete pro‐tumorigenic senescent cells, offer a novel adjuvant strategy to re‐engineer the tumor microenvironment and potentiate anticancer therapy. However, direct senolytic treatment poses significant safety risks, and selectively eliminating senescent cells to treat …

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Characteristics and prognostic implications of TP53 mutations in Chinese patients with myelodysplastic syndromes

Nanfang Huang, Chun-Kang Chang, Lingyun Wu, Qi He et autres

Tumour protein p53 (TP53) mutations occur frequently in myelodysplastic syndromes (MDS) and are associated with a high risk of treatment failure and adverse outcomes. In this study, we analysed 1219 patients with MDS, focusing on the clinical and molecular characteristics of those …

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Hereditary transthyretin cardiac amyloidosis with Glu109Lys mutation presenting with low sensitivity to 99mTc pyrophosphate in scintigraphy: a case description

Yun-Peng Wei, Dachun Zhao, Xiao Li, Chao Ren et autres

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Guidelines for cervical cancer screening in China II

Mingzhu Li, Jingran Li, Xiao Li, Xinyu Wang et autres

Cervical cancer is a common malignant tumour that has become a major global public health issue, seriously threatening women’s lives. In November 2020, the WHO released a global strategy to accelerate the elimination of cervical cancer as a public health problem. So …

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In Reply

Xiao Li, Hongyu Xie, Xinyu Wang

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Genomics insights of candidiasis: mechanisms of pathogenicity and drug resistance

Xin Huang, Qin Dong, Qi Zhou, Yuanzhong Xu et autres

Candidiasis, a prevalent class of human infections caused by fungi belonging to the Candida genus, is garnering increasing attention due to its pathogenicity and the emergence of drug resistance. The advancement of genomics technologies has offered powerful tools for investigating the pathogenic …

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Methylation of SOX1 and PAX1 Are Risk Factors and Potential Biomarkers for Cervical Lesions

Xiao Li, Li Wei Shao, Ai Jun Liu

Background: The correlation between methylation of paired box gene 1 (PAX1) and sex determining region Y-box 1 (SOX1) with human papillomavirus (HPV) infection and the progression of cervical lesions is not well understood. This study aims to explore the potential value of …

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Age-specific 3-year risk of cervical precancer among HPV-positive women attending screening: a post hoc analysis from a retrospective cohort

Ruizhe Chen, Ying Li, Xiao Li, Xinyu Wang et autres

This post hoc analysis explored the age-specific risk of cervical precancer in women infected with human papillomavirus (HPV), using data from a cohort of 7263 participants aged 21-71years undergoing cervical screening. We found a slightly varied prevalence of high-risk HPV (hrHPV) in …

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In silico prediction of drug-induced nephrotoxicity: current progress and pitfalls

Na Li, Juan Shi, Zhaoyang Chen, Zhonghua Dong et autres

Introduction Due to its role in absorption and metabolism, the kidney is an important target for drug toxicity. Drug-induced nephrotoxicity (DIN) presents a significant challenge in clinical practice and drug development. Conventional methods for assessing nephrotoxicity have limitations, highlighting the need for …

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