Zhiming Wang

An inner filter effect-based organic small-molecule fluorescent probe for vitamin B12 sensing and cell imaging

Zhiming Wang, Songtao Cai, Chang Liu, Xianshun Zeng

cn (code pays fourni par la source)

Regioselective Nucleophilic Diamination of Quinones Enabling Access to 3,5-, 3,6-, and Mixed Diamino Derivatives: Synthesis and Photocurrent Characterization

Wenjing Lu, Xianqiang Huang, Xiaoxue Jiang, Lirong Jiang et autres

In this study, we disclose a Cu(OTf)2-catalyzed regioselective nucleophilic amination of quinones to synthesize 3,5-, 3,6-, and mixed diaminoquinones under air. The regioselectivity, controlled by the catalyst coordination and the steric hindrance of amines, follows different patterns: the reactions with anilines afforded …

cn (code pays fourni par la source)

Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior

Shuo Lv, Jinlong Li, Ruoqi Yang, Wu Xin et autres

The cerebellum plays a critical role in large-scale brain functional connectivity structure and synchronizing global waves propagation. Despite extensive studies on cortical spatiotemporal architecture, particularly in zero-lag and time-lag synchrony, leaving the parsimonious cerebellar representational structure largely overlooked. Using complex principal component …

cn (code pays fourni par la source)

Characterization of the Intestinal Metabolic Profiles Following Photon FLASH Irradiation

Siqian Zhang, Qiliang Peng, Jun Zhang, Zhiming Wang et autres

Objective: Ultra-high dose rate radiotherapy, commonly referred to as FLASH radiotherapy, is a transformative focus in radiotherapeutic research. This study aimed to identify intestinal contents based metabolic biomarkers of photon FLASH. Methods: C57BL/6J mice were exposed to 0 Gy, 10 Gy, 12 …

cn (code pays fourni par la source)

Condition-Controlled Divergent Synthesis Sulfur-Containing Ester Derivatives from 3 H -Benzo[ c ][1,2]dithiol-3-one and 3-Arylprop-2-yn-1-ols

Guodong Shen, Lirong Jiang, Shuwen Gong, Lilong Shi et autres

We report an efficient, one-pot, condition-controlled divergent synthesis strategy through nucleophilic cyclization or Meyer–Schuster rearrangement pathways to construct C–S and C–O bonds for the synthesis of sulfur-containing esters by the opposite reaction conditions (Lewis acid or Brønsted base catalyst). One pathway proceeds …

cn, us (code pays fourni par la source)

Three parsimonious spatiotemporal patterns in cerebellum reveal individual traits in function and behavior

Guoyuan Yang, Shuo Lv, Jinlong Li, Ruoqi Yang et autres

cn, us (code pays fourni par la source)

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential

Zhiming Wang, Zhifei Cao, Mengmeng Xu, Yongsheng Zhang

Microsatellite instability (MSI) is a key feature of cancers with defective DNA mismatch repair, including colorectal, gastric, endometrial, and ovarian cancers. Tumors with MSI depend on the Werner syndrome protein (WRN) for genomic stability, making WRN an attractive therapeutic target. WRN inhibitors …

cn (code pays fourni par la source)

Development of areal-level individualized homologous functional parcellations in youth

Jinlong Li, Yu Zhang, Wu Xin, Mufan Xue et autres

Individualized functional brain networks from childhood to adolescence undergo varying patterns of maturation, associated with higher-order cognition outcomes. However, the developmental trajectory patterns based on homologous areal-level brain parcellations remain elusive. Here, we developed an individualized homologous functional parcellation technique (IHFP) to …

cn (code pays fourni par la source)

Utilizing Peanut Oleosome to Stabilize Emulsifier-Free Casein–Maltodextrin–Peanut Oil Emulsion: A Comparative Study

Zhihao Zhao, Zhiming Wang, Pengfei Zhou, Guang Liu et autres

High Resolution Image Download MS PowerPoint Slide In recent years, growing concerns over the potential health risks of food emulsifiers have driven the search for natural alternatives. Oleosomes, naturally pre-emulsified lipids, hold great promise for developing emulsifier-free emulsion products. However, research on …

cn (code pays fourni par la source)

Electrochemically Enabled Chemodivergent Azidohydroxylation and Diazidation of Trifluoromethylalkenes with Trimethylsilyl Azide

Zewei Xie, Caiyue Li, Xiaolei Zhu, Haijian Wu et autres

A facile and straightforward electrochemical oxidative azidohydroxylation and diazidation of α-CF 3 alkenes with TMSN 3 has been achieved. Significantly, a series of densely functionalized and potentially medicinally valuable β-trifluoromethylated azido compounds were assembled under mild conditions using a constant current in …

cn (code pays fourni par la source)

Research progress of T cells in cholangiocarcinoma

Zhiming Wang, Yunyan Dai, Yunpeng Zhou, Yi Wang et autres

Cholangiocarcinoma (CCA), a malignant tumor, is typically challenging to detect early and often results in a poor prognosis. In recent years, research interest has grown in the potential application of immunotherapy for CCA treatment. T cells, as a crucial component of the …

cn (code pays fourni par la source)

Hexafluoroisopropanol (HFIP)-Promoted Hydrodifluoroalkylation of Furans and Vinyl Ethers Using Difluorinated Silyl Enol Ethers for the Synthesis of gem-Difluorinated Ethers

Xiaogang Zhou, Jing Zhang, Manman Sun, Haiqin Yang et autres

A hexafluoroisopropanol (HFIP)-promoted hydrodifluoroalkylation of furans and vinyl ethers with difluorinated silyl enol ethers has been developed. Because of the inherent electron richer nature of furans and the poor nucleophilicity of difluorinated silyl enol ethers, the employment of simple furans as the …

cn, us (code pays fourni par la source)