Jiayu Wang

Nano-hydrogel-based delivery system for dihydroartemisinin to enhance cuproptosis and synergize with anti-PD-1 therapy in triple-negative breast cancer

Qiaoli Yi, Fada Xia, Tong‐Fei Li, Jiayu Wang et autres

As an aggressive subtype of breast cancer, triple-negative breast cancer (TNBC) displays limited therapeutic options and poor clinical prognosis. Thus, there is an urgent need for developing more effective treatment strategies to optimize the clinical management of TNBC. Dihydroartemisinin (DHA), one kind …

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Evaluation of basic life support practice skills based on artificial intelligence technology: system construction and evaluation equivalence validation

Yan Jiang, Yuehua Chen, Yin Zhang, Jiayu Wang et autres

BACKGROUND: Basic life support (BLS) skills are the core competencies of healthcare professionals in responding to emergency situations. Traditional manual assessments suffer from subjective bias, low efficiency, and are affected by examiner fatigue. Artificial intelligence (AI) technology brings innovative opportunities for skill …

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Er Miao San and its main components phellodendrine and atractylenolide-I exert anti-rheumatoid arthritis effects by inhibiting PAD4 and thereby reducing the formation of NETs

Ran Tang, Jia-Hua Yin, Jiayu Wang, Wenrui Su et autres

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Piezo mediates oviposition in shielding gaps to protect moth eggs from parasitoid wasp

Baiwei Ma, Dong Ai, Liwei Zhang, Hanbo Zhao et autres

Where to lay eggs is critical for insect females to avoid risks and ensure offspring survival. Females of the oriental armyworm, Mythimna separata, deposit their eggs inside narrow slits to evade predators. However, the sensory mechanism by which they choose the optimal …

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A phase IIa clinical trial of ABP1011T monotherapy in patients with advanced malignant solid tumors.

Binghe Xu, Jiayu Wang, Zheng-Yun J. Zhan, Haiping Wang et autres

e15145 Background: ABP1011 T is an innovative tyrosine kinase inhibitor (TKI) that effectively inhibits EGFR, c-MET, FGFR1-4, VEGFR1-3, RET, and c-KIT. Importantly, it exhibits broader superior inhibitory activity compared to Lenvatinib and Regorafenib. In the completed clinical phase I trial, 12 types …

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Influence of borehole trajectory and pressure on the characteristics of drilling induced fractures

Jiayu Wang, Zihan Zhu, Mu-Yuan Li, Xinwei Zhao et autres

Research on the identification and classification of drilling-induced fractures plays a critical role in clarifying the mechanisms of wellbore instability and drilling fluid loss, while also supporting the analysis of imaging logging data and reservoir evaluation. In this study, a prediction model …

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Receptor-based bioassay for functional IL-2 quantification

Chuan-Wei Lu, Shuangshuang Xu, Xue-Lian Shan, Jiayu Wang et autres

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The key active ingredients identification and pharmacological mechanism investigation of extract of ethyl acetate from Er Miao San aganist rheumatoid arthritis

Jiayu Wang, Ran Tang, Si-Meng Chen, Wenrui Su et autres

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Geometric Constraint Model and Solution for AUV Seabed Following Path

Rupeng Wang, Jiayu Wang, Wenqiang Sun, Zixiang Fu et autres

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Scutellarin alleviated ulcerative colitis through gut microbiota-mediated cAMP/PKA/NF-κB pathway

Yang Li, Mengdan Yan, Miao Zhang, Bo Zhang et autres

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Therapeutic potential of cannabidiol (CBD) in anxiety disorders: A systematic review and meta-analysis

Kevin Han, Jiayu Wang, Pengyun Wang, Y. -K. M. Peng

Cannabidiol (CBD), as one of the phytocannabinoids, has a wide range of therapeutic properties for various neuropsychiatric disorders due to central nervous system effects. These therapeutic properties demonstrated by preclinical and clinical studies encompass more than just anticonvulsant, anti-arthritic, analgesic, anti-inflammatory, antioxidant, …

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TrAISformer: Spatio-Temporal Ship Trajectory Prediction Based on Transformer

Yunbo Li, Jiayu Wang, Tao Li, Zheng Yi Fu

Spatio-temporal ship trajectory prediction is an important issue for maritime traffic management and safety. This research introduces a pioneering technique predicated on a Transformer architecture, specifically designed for the precise forecasting of maritime vessels' paths in forthcoming intervals. Utilizing archival navigational data …

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