Nan Liu

Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma

Zan Gao, Le Sun, Jianlong Li, Heng Lv et autres

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3S-DB identifies an RNA repository facilitating stop codon readthrough for selenocysteine insertion and selenoproteome expansion

Chenfang Si, Lu Zhang, Jing Gao, Kongyan Niu et autres

Selenoproteins contain the selenocysteine (Sec, U), which is essential for redox regulation due to its reactive selenol group. The current set of 25 human selenoproteins was defined by the presence of SECIS elements in the 3’ UTR coupled with in-frame UGA codons …

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Epitranscriptomic analysis reveals features of NAD-capped RNAs upon supplementation of nicotinamide mononucleotide in human

Shuwen Ge, Yandong Liu, Dean Li, Guojing Han et autres

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Differences of respiratory tract flora and metabonomic characteristics of lung lavage fluid in pneumoconiosis model rats

Wei Gao, Hao Han, Shuyu Xiao, Shuling Yue et autres

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CompasSeq: epitranscriptome-wide percentage assessment of metabolite-capped RNA at the transcript resolution

Yuanbo Liu, Dean Li, Xueting Wang, Kongyan Niu et autres

Nucleotide-containing metabolites, e.g., NAD, can serve as noncanonical initiating nucleotides (NCIN) during transcription, yielding NCIN-capped RNAs (NCIN-RNAs). Current profiling strategies are limited to detecting specific metabolite caps and lack an epitranscriptome-wide approach for quantifying the ratio between NCIN- and m7G-capped forms. Here, …

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3S-DB Identifies an RNA Repository Facilitating Stop Codon Readthrough for Selenocysteine Insertion and Selenoproteome Expansion

Chenfang Si, Pengfei Zhang, Jing Gao, Kongyan Niu et autres

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Multiomics driven identification of glycosyltransferases in flavonoid glycoside biosynthesis in safflower

Nan Liu, Yu-Pan Zou, Zhouqian Jiang, Lichan Tu et autres

Safflower is an important oilseed crop that has been used in traditional Chinese medicine for thousands of years because of the clinically valuable flavonoid glycosides in its flower petals. However, the biosynthesis and molecular regulation of these compounds are still elusive due …

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Refining the genetic diagnostic puzzle: A case report on a Chinese ARPKD patient with a reciprocal balanced translocation and c. 2507 T > C (p. V836A ) in PKHD1

Xiaoyu Liu, Wenchao Sheng, Nan Liu, Wenxuan Fan et autres

INTRODUCTION: Autosomal recessive polycystic kidney disease (ARPKD) ranks among the most severe chronic kidney diseases (CKD). Its primary cause is variants in the Polycystic Kidney and Hepatic Disease 1 gene (PKHD1). The clinical spectrum of ARPKD varies widely, ranging from mild late-onset …

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miR-485-5p acts as a negative regulator of sepsis-associated acute kidney injury through targeting ICAM-1

Rui Wang, Yongheng Wang, Shuang Li, Yu Zhang et autres

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Regulatory mechanism of the Glabrene against non‐small cell lung cancer by suppressing FGFR3

Miao He, Huiling Wu, Lingjing Hu, Nan Liu et autres

BACKGROUND: Non-small cell lung cancer (NSCLC) is a highly malignant tumor with limited effective treatment options. This study aimed to investigate the regulatory mechanism of Glabrene on NSCLC through its interaction with FGFR3. METHODS: HCC827 cells were implanted into nude mice and …

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Quantitative Acetylomics Reveals Substrates of Lysine Acetyltransferase GCN5 in Adult and Aging Drosophila

J.G. Li, Ye Cao, Yun Yang, Huanhuan Ma et autres

Protein lysine acetylation is a dynamic post-translational modification (PTM) that regulates a wide spectrum of cellular events including aging. General control nonderepressible 5 (GCN5) is a highly conserved lysine acetyltransferase (KAT). However, the acetylation substrates of GCN5 in vivo remain poorly studied, …

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Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep

Benmeng Liang, Tianyou Bai, Yuhetian Zhao, Jiangang Han et autres

INTRODUCTION: Fine-wool sheep are the most common breed used by the wool industry worldwide. Fine-wool sheep have over a three-fold higher follicle density and a 50% smaller fiber diameter than coarse-wool sheep. OBJECTIVES: This study aims to clarify the underlying genetic basis …

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