Accès ouvert
2026
article
OpenAlex
Miao Yu, Pengcheng Guo, Qingfeng Liu, Xinan Zhang
Introduction This review summarizes evidence on how anti-aging diets and exercise influence age-related musculoskeletal diseases through modulation of the gut microbiota. With population aging, these diseases are public health concerns. The gut microbiota regulates bone, joint, and muscle health via the gut‑joint, …
cn
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2026
article
OpenAlex
Jiayi Luo, Xin Meng, Juanjuan Han, Hui Kong et autres
Significance: The global aging population has led to an increasing burden of age-related orthopedic diseases, seriously imposing social and economic pressures. Although exercise has been proven to have a protective effect on the musculoskeletal system, diseases themselves often restrict patients from engaging …
cn
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Accès ouvert
2025
article
OpenAlex
Haixia Wang, Juanjuan Han, Xinan Zhang
Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by cartilage degradation, bone hyperplasia, and synovitis. It is a primary cause of joint pain and dysfunction globally. The increasing incidence of OA, driven by an aging population, profoundly impairs patients' quality of …
cn
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Accès ouvert
2025
article
OpenAlex
Zhigang Fan, Xinan Zhang, Yewen Zhang, Mingu Kang
Against the backdrop of Chinese modernization and high-quality development, how to enhance corporate sustainability through the integration of digital and physical technologies has become a central concern for both academia and practice. Based on panel data from Chinese A-share listed companies spanning …
cn, kr
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2025
article
OpenAlex
Cuihong Yang, Xinan Zhang, Linchao Hu, Jianshe Yu et autres
In the interactive dynamical models, we include two different competing wild mosquito species and sterile mosquitoes which are the same type as one of the competing wild mosquitoes. We study the dynamics of the interspecific competition models in different circumstances. We explore …
cn, us
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Accès ouvert
2025
article
OpenAlex
Guangxin Wang, Xiao Liu, Xinan Zhang, Mingjie Hu
The meniscus, an important fibrocartilaginous structure within the knee joint, plays essential roles in shock absorption, joint stabilization, and the optimization of mechanical force transmission. Meniscus injuries are common among athletes, middle-aged and elderly individuals, and those engaged in heavy physical labor. …
cn
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Accès ouvert
2025
article
OpenAlex
Hui Kong, Juanjuan Han, Guo Ming Liang, Xinan Zhang
BACKGROUND: Bone metabolic diseases constitute a group of disorders characterized by abnormal alterations in bone mass and skeletal metabolism, often resulting from oxidative stress, nutritional deficiencies, and various other etiological factors. Post-translational modification (PTM), a critical mechanism of protein regulation, plays a …
cn
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Accès ouvert
2025
article
OpenAlex
Juanjuan Han, Xin Meng, Hui Kong, Xinran Li et autres
Short-chain fatty acids (SCFAs), the primary metabolites produced by the microbial fermentation of dietary fibers in the gut, have a key role in protecting gut health. Increasing evidence indicates SCFAs can exert effects on distant tissues and organs beyond the gut via …
cn
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Accès ouvert
2025
article
OpenAlex
Yunxiang Mu, Yaqi Zhou, Xinan Zhang, Yiming Shao
Background: Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related disorders, but long-term use has been increasingly associated with an elevated risk of osteoporosis. However, the underlying molecular mechanisms and specific targets of PPIs-induced bone loss remain poorly understood. …
cn
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Accès ouvert
2025
article
OpenAlex
Hui Kong, Qi He, Juanjuan Han, Xinan Zhang
Osteoarthritis (OA) represents a chronic joint disease characterized by articular cartilage degeneration, synovial inflammation, and subchondral bone erosions. Functional cells in OA mainly include macrophages, synoviocytes, chondrocytes, and mesenchymal stem cells. These cells can secrete cytokines and non-coding RNAs and exosomes and …
cn
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Accès ouvert
2025
article
OpenAlex
Lijie Liu, Jiale Zhang, Na Wang, Yun Zhang et autres
Regular exercise positively influences bone health, enhances bone density and strength, and reduces the risk of osteoporosis. Silent information regulator of transcription 1 (SIRT1) is a deacetylase that plays a pivotal role in the regulation of various biological processes. In this review, …
cn
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2025
article
OpenAlex
Hui Kong, Juanjuan Han, Yuanyuan Bian, Xinan Zhang
The complex and diverse living conditions in the ocean have created the distinctive structure and physiological activities of marine natural products, which distinguish them from land-based natural products. Most of bioactive compounds extracted from marine organisms exhibit favorable pharmacological activities such as …
cn
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