Na Wang

Integrating GC ‐ TOF ‐ MS , ROAV and Chemometrics to Understand the Flavour Characteristics of arabica Coffee Varieties in Yunnan

Hongyan Chen, Xian Chen, Na Wang, Xinxiang Fan et autres

ABSTRACT The Yunnan Province is the primary coffee‐growing region in China. In this study, the flavour components of seven arabica coffee varieties in Yunnan were detected by headspace solid‐phase microextraction‐gas chromatography time‐of‐flight mass spectrometry (HS‐SPME‐GC‐TOF‐MS) and a total of 178 volatile components …

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SIRT1 and exercise-induced bone metabolism: a regulatory nexus

Lijie Liu, Jiale Zhang, Na Wang, Yun Zhang et autres

Regular exercise positively influences bone health, enhances bone density and strength, and reduces the risk of osteoporosis. Silent information regulator of transcription 1 (SIRT1) is a deacetylase that plays a pivotal role in the regulation of various biological processes. In this review, …

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Mechanistic study of Huangqi Guizhi Wuwu decoction amelioration of doxorubicin-induced cardiotoxicity by reducing oxidative stress and inhibiting cellular pyroptosis

Yu Chen, Meng Xu, Xiaomei Liu, Jianxin Wang et autres

Huangqi Guizhi Wuwu Decoction (HQGZWWD) has shown promising potential in treating various cardiovascular diseases. This study aimed to elucidate the molecular basis and therapeutic role of HQGZWWD in the treatment of doxorubicin (DOX)-induced myocardial injury. The HPLC fingerprint of HQGZWWD was used …

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Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress

Dan Li, Rong Shao, Na Wang, Nan Zhou et autres

Oxidative stress underlies a number of pathological conditions, including cancer, neurodegeneration, and aging. Antioxidant-rich foods help maintain cellular redox homeostasis and mitigate oxidative stress, but the underlying mechanisms are not clear. For example, sulforaphane (SFN), an electrophilic compound that is enriched in …

Cyclovirobuxine D pretreatment ameliorates septic heart injury through mitigation of ferroptosis

Jianxin Wang, Peng Guan, Yu Chen, Meng Xu et autres

Myocardial dysfunction is a frequent complication in patients with severe sepsis. However, effective drugs for the prevention of myocardial dysfunction and the molecular mechanisms of the disease remain elusive. The present study demonstrated that Cyclovirobuxine D (CVB‑D) could improve cardiac dysfunction in …

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Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy

Bingyang Liu, Guilan Chen, Feng Guo, Xiaoxue Xu et autres

Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity, which triggers cell death in various neuropathological diseases, including epilepsy. Studies have shown that inhibition of neuronal nitric oxide synthase activity increases the epilepsy threshold, that is, has an anticonvulsant effect. However, the …

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Protective Mechanism of Gandou Decoction in a Copper-Laden Hepatolenticular Degeneration Model: In Vitro Pharmacology and Cell Metabolomics

Fengxia Yin, Mengnan Nian, Na Wang, Hongfei Wu et autres

Gandou decoction (GDD) is a classic prescription for the treatment of hepatolenticular degeneration (HLD) in China; however, the liver-protecting mechanism of this prescription needs further evaluation. In the present study, we explored the protective mechanisms of GDD in a copper-laden HLD model …

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Therapeutic Potential of Astragaloside IV Against Adriamycin-Induced Renal Damage in Rats via Ferroptosis

Lu-Yun Qin, Peng Guan, Jianxin Wang, Yu Chen et autres

Adriamycin (ADR) has been utilized to treat cancer for several decades. However, ADR-induced renal injury is one of the most common side effects accompanying ADR therapy. In the present study, we revealed that astragaloside IV (ASIV) was beneficial for renal injury caused …

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Anti-osteoporosis effects and regulatory mechanism of Lindera aggregata based on network pharmacology and experimental validation

Furong Wang, Peng‐Ze Rong, Juan Wang, Yu Xiao et autres

. Our results demonstrated the reliability of the network pharmacology method, and also revealed the anti-OP effect and potential mechanism of RLA.

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Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy

Li-Fei Luo, Lu-Yun Qin, Jianxin Wang, Peng Guan et autres

Astragaloside IV (ASIV) is the main active component of Astragalus, and can ameliorate cardiomyocyte hypertrophy, apoptosis and fibrosis. In this experiment, we studied how ASIV reduces the cardiotoxicity caused by adriamycin and protects the heart. To this end, rats were randomly divided …

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Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

Li-Fei Luo, Peng Guan, Lu-Yun Qin, Jianxin Wang et autres

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The effect of different tobacco tar levels on DNA damage in cigarette smoking subjects

Congcong Zhao, Yuanchen Xie, Xiaoshan Zhou, Qiao Zhang et autres

Abstract Objective To explore the genetic damage caused by different tar levels in the human body. Methods The subjects were divided into high, medium and low (12 mg, 8 mg, 5 mg) tar groups according to the tar levels. Nonsmoking populations served …

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