Bin Li

Pavement performance of light-coloured composite-modified binder and mixture for tunnel applications

Chuangchuang Song, Guohong Zhang, Ping Li, Fukui Zhang et autres

Traditional asphalt pavements absorb substantial light and lower luminance contrast inside tunnels, causing visual fatigue for drivers. Light-coloured pavements enhance light reflection to improve tunnel visual environments and traffic safety. This study prepares a light-coloured composite-modified binder using naphthenic oil, C9 resin, …

cn, us (code pays fourni par la source)

Targeted screening of natural thrombin inhibitors from herbal extracts using an enzyme-immobilized microfluidic reactor

Xian-Na Wang, Ji Zhang, Yahui Song, Ruiping Song et autres

monitoring of the thrombin reaction using fluorescence microscopy, and its enzymatic hydrolysate was detected and quantified using MALDI MS. The reproducibility of the EIMR was significantly improved by optimizing conditions for thrombin immobilization and the concentration of a fluorescent substrate. As a …

cn (code pays fourni par la source)

Unraveling the alteration of chemical compositions in Cordyceps and its host larvae using mass spectrometry imaging

Shipeng Sun, Yuchen Zou, Weiwei Tang, Zhengming Qian et autres

Cordyceps (Chinese caterpillar fungus) is a precious medicinal and edible fungus-larva complex that is naturally formed in a specific environment. However, limited data have been reported on spatial alterations in the lipidome and metabolome of larvae before and after entomopathogenic fungal infection. …

cn (code pays fourni par la source)

Bioactive Neo-Clerodane Diterpenoids from Baccharis trimera: Identification and Hepatoprotective mechanisms

Yong Qi Liang, Jianping Hu, Hongdong Liu, Tao Jiang et autres

cn (code pays fourni par la source)

Expanding Metabolome Coverage in LC–MS/MS Analysis through Hydralazine-Based Multifunctional Derivatization

Zhiye Yan, Weiwei Tang, Bin Li

Metabolomics is a potent tool used for discovering disease biomarkers and investigating intricate mechanisms of diseases by analyzing metabolite changes in biological systems. However, challenges in metabolite detection have not been fully addressed due to their vast physicochemical diversity and broad concentration …

cn (code pays fourni par la source)

Identification of a novel O-glycosyltransferase PgGT2 for catalyzing the first glycosylation step of saponin synthesis in Platycodon grandiflorum

Zhenlin Li, Wenjing Yu, Weiwei Tang, Bin Li

cn (code pays fourni par la source)

Image Fusion for Super‐Resolution Mass Spectrometry Imaging of Plant Tissue

Yuchen Zou, Shipeng Sun, Weiwei Tang, Bin Li

Mass spectrometry imaging (MSI) is a vital tool in botanical research. Image fusion is introduced for resolution enhancement of MSI data from animal samples, but its application to plant MSI data resulted in unsatisfactory visualizations due to the distinct morphological characteristics of …

cn (code pays fourni par la source)

2,5-Dimethoxy-4-methylamphetamine (DOM)-induced gait alterations in mice: Dissecting the role of 5-HT2A/2C receptor-mediated mechanisms

Bin Li, Shanshan Jiang, Yishan Yao, Gang Yu et autres

cn (code pays fourni par la source)

Metabolic Inhibitor Loaded Metal–Phenolic Nanocapsules Enable Synergistic Cancer Therapy through Cuproptosis and Immunometabolic Reprogramming

Bin Li, Houyang Hu, Songyan Li, Xuechun Wang et autres

Abnormal glycolysis and glutamine metabolism not only sustain tumor growth but also reprogram the tumor microenvironment (TME). However, due to compensatory mechanisms and low tumor immunogenicity, targeting a single metabolic pathway is often insufficient for effective cancer therapy. We here developed dual-starvation …

gb, Soudan, cn (code pays fourni par la source)

[Research progress on biosynthesis and metabolic regulation of flavonoids in Ginkgo biloba].

Yaju Li, Jiacheng Gong, Bin Li, Xu Lu

Ginkgo biloba, an ancient relict plant, holds a lengthy medicinal tradition in China. The leaves and seeds of this remarkable species contain flavonoids, a class of active compounds that offer a multitude of pharmacological advantages. The understanding of the synthesis process of …

cn (code pays fourni par la source)

[Immune function regulation and tumor-suppressive effects of Shenqi Erpi Granules on S_(180) tumor-bearing mice].

Xiong-Wei Zhang, Jiang Yan-ning, Hu Qi, Bin Li et autres

This study aims to establish the S_(180) tumor-bearing mice model, and to investigate the influence of Shenqi Erpi Granules(SQEPG) on immune function, as well as the drug's tumor-suppressive effect and mechanism. SPF grade KM mice(half male and half female) were randomly divided …

cn (code pays fourni par la source)

Laser desorption/ionization target chip: a transformative platform for pharmaceutical research

Weiwei Tang, Yuchen Zou, Pei Zhong, Zhen Li et autres

cn (code pays fourni par la source)