Zhiyong Yan

A retrospective and in silico study on the augmentation of risperidone in the treatment of adolescent treatment-resistant depression: efficacy evaluation, adverse reaction analysis, and molecular mechanistic insights

Xiaoli Shen, Zhiyong Yan

Background Major depressive disorder (MDD) in adolescents remains a significant public health challenge. Treatment-resistant depression (TRD) affects a substantial proportion of cases and is associated with chronic symptoms, comorbidities, and elevated suicide risk. Standard treatments frequently show limited success, leading to off-label …

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Integrated Multiomics Analysis and Mendelian Randomization Identify SIRT1 as a Pivotal Aging‐Associated Gene in Meningioma

Guangyu Du, Daikang Xu, Jingxian Sun, Shusheng Che et autres

Meningiomas (MGMs) are the most prevalent benign intracranial tumors in adults, with incidence markedly increasing with age, underscoring the need to explore aging-associated molecular mechanisms. In this study, we integrated transcriptomic datasets (GSE43290, GSE54934, GSE77259, and GSE183655) from the GEO database and …

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Integration of network pharmacology and untargeted metabolomics reveals Changpu San's antidepressant mechanisms via tryptophan metabolism

Fang Xiang, Lin Hu, Shengqi Zhang, Peng‐Cheng Lv et autres

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Valeriana jatamansi jones improves depressive behavior in CUMS mice by modulating vitamin B12-related ileal homeostasis

Peng‐Cheng Lv, Fang Xiang, Shengqi Zhang, Guihua Wei et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Valeriana jatamansi Jones (V. jatamansi) is a traditional Chinese medicine (TCM). It was recorded in Diannan Bencao, Compendium of Materia Medica and some local medical books and was described as useful in treating insomnia, distraction, poor mental health, vomiting and …

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Valeriana Jatamansi: An Overview of Phytochemistry, Pharmacology, Clinical Prospects, and Network Analysis of Drug Targets

Siyu Zhao, Xiaoyun Ji, Junxiang Li, Delong Han et autres

Valeriana jatamansi Jones (V. jatamansi) has a long history of medicinal use owing to its significant therapeutic effects, particularly in the treatment of mental diseases such as depression, and on account of its cytotoxicity against various cancer cells. The chemical composition, pharmacological …

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Qisheng wan decoction alleviates the inflammation of CCI rats via TRP channels

Guihua Wei, Chunxiao Xiang, Haoyan Wang, Li Xi et autres

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Streaming Audio Transformers for Online Audio Tagging

Heinrich Dinkel, Zhiyong Yan, Yongqing Wang, Junbo Zhang et autres

Unveiling the intratumoral microbiota within cancer landscapes

Shusheng Che, Zhiyong Yan, Yugong Feng, Zhao Hai

Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role of intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, and viruses within tumor tissues, have been found to exert considerable influence on tumor …

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Microbiota Alterations in Lung, Ileum, and Colon of Guinea Pigs with Cough Variant Asthma

Chongyang Dou, Lin Hu, Xian Ding, Fangfang Chen et autres

Alterations in the microbiota composition, or ecological dysbiosis, have been implicated in the development of various diseases, including allergic diseases and asthma. Examining the relationship between microbiota alterations in the host and cough variant asthma (CVA) may facilitate the discovery of novel …

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The mechanism of mineral dissolution and its impact on pore evolution of CO2 flooding in tight sandstone: A case study from the Chang 7 member of the Triassic Yanchang formation in the Ordos Basin, China

Wei Wang, Zhiyong Yan, Dayou Chen, Yi He et autres

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Peroxisome proliferator‐activated receptors signature reveal the head and neck squamous cell carcinoma energy metabolism phenotype and clinical outcome

Yao Zong YUAN, Di Wang, Yu Zhang, Qiaofei Tang et autres

BACKGROUND: Peroxisome proliferator activating receptors (PPARs) are important regulators of nuclear hormone receptor function, and they play a key role in biological processes such as lipid metabolism, inflammation and cell proliferation. However, their role in head and neck squamous cell carcinoma (HNSC) …

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CED: Consistent ensemble distillation for audio tagging

Heinrich Dinkel, Yongqing Wang, Zhiyong Yan, Junbo Zhang et autres

Augmentation and knowledge distillation (KD) are well-established techniques employed in audio classification tasks, aimed at enhancing performance and reducing model sizes on the widely recognized Audioset (AS) benchmark. Although both techniques are effective individually, their combined use, called consistent teaching, hasn't been …