Xiaoli Shen

Panax ginseng-derived peptides as natural dipeptidyl peptidase-IV inhibitors: screening, binding mechanisms, and potential for glycemic management in functional foods

Yan Zhang, Yuenan Xing, Xiaoli Shen, Wannan Li et autres

Panax ginseng is a protein-rich medicinal crop with great potential as a source of bioactive peptides. Dipeptidyl peptidase-IV (DPP-IV) is an important therapeutic target for type 2 diabetes mellitus (T2DM), and natural DPP-IV inhibitory peptides have attracted increasing attention as functional food …

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RETRACTED: DENND2D is a novel biomarker associated with poor prognosis in low-grade gliomas and tumor-associated macrophages (TAMs)

Tang Xiaolong, Tan Zilong, Ye Qinglin, Huang Hui et autres

Background DENND2D, a key member of the DENND2 family, plays a significant role in the pathogenesis and progression of various diseases, including high-grade gliomas, colon cancer, bladder cancer, and sepsis. However, its function in low-grade gliomas (LGG) remains unclear. Methods This study …

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A retrospective and in silico study on the augmentation of risperidone in the treatment of adolescent treatment-resistant depression: efficacy evaluation, adverse reaction analysis, and molecular mechanistic insights

Xiaoli Shen, Zhiyong Yan

Background Major depressive disorder (MDD) in adolescents remains a significant public health challenge. Treatment-resistant depression (TRD) affects a substantial proportion of cases and is associated with chronic symptoms, comorbidities, and elevated suicide risk. Standard treatments frequently show limited success, leading to off-label …

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RBM43 promotes glioma aggressiveness and shapes the immune microenvironment through macrophage polarization

Zilong Tan, DaPeng Wang, Xiaolong Tang, H Y Wei et autres

OBJECTIVE: To investigate the expression pattern of RBM43 in glioma and evaluate its prognostic significance, with particular attention to its association with the glioma immune microenvironment. METHODS: RBM43 expression, clinicopathological associations, and prognostic value were analyzed using RNA-seq data from the TCGA …

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Chemical imaging of individual stratospheric particles sampled over North America

Steven Sharpe, Yaowei Li, Sophia Benjemia, Felipe A. Rivera-Adorno et autres

Chemical imaging was used to examine the morphology, composition, and mixing state of stratospheric particles. The results showed evidence of wildfire-derived black carbon and organic material reaching the upper troposphere and lower stratosphere.

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Refractive error after phacoemulsification combined with intraocular lens implantation in primary angle-closure glaucoma: a multifactorial analysis of biometric parameters and surgical strategies

Yong Liu, Kuanrong Dang, Di Gong, Simin Deng et autres

Purpose: This study aims to explore the factors influencing refractive error following Phacoemulsification combined with intraocular lens implantation (PE + IOL) in patients with primary angle-closure glaucoma (PACG), providing a theoretical basis for preoperative consultation and IOL power selection in clinical practice. …

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The Dynamics and Chemistry of the Summer Stratosphere (DCOTSS) Project

Kenneth P. Bowman, Frank N. Keutsch, Cameron R. Homeyer, D. S. Sayres et autres

Abstract Overshooting storms are convective systems with updrafts that penetrate through the tropopause into the overlying stratosphere. These storms can rapidly transport a wide variety of chemical species and aerosols from the boundary layer and free troposphere directly to the stratosphere. The …

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Imaging micrometer-sized aerosol particles with digital holography

Matthew J. Berg, Justin Jacquot, Jeremy M. Harris, Xiaoli Shen

Small particles that are trapped, deposited, or otherwise fixed can be imaged by digital holography with a resolution approaching that of optical microscopy. When such particles are in motion as an aerosol, a comparable resolution is challenging to achieve. Using a simplified …

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A new airborne single particle mass spectrometer: PALMS-NG

Justin Jacquot, Xiaoli Shen, Maya Abou‐Ghanem, K. D. Froyd et autres

An updated version of the Particle Analysis by Laser Mass Spectrometry (PALMS) instrument, termed PALMS-NG (-Next Generation), has been designed to characterize particles in the troposphere and stratosphere. Two PALMS-NG instruments have been built: a Purdue University version, which has flown on …

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Comment on egusphere-2024-90

Hengheng Zhang, Wei Huang, Xiaoli Shen, Ramakrishna Ramisetty et autres

Abstract. Aerosol distribution is of great relevance for air quality especially for the cities like Stuttgart which is located in a basin. To understand the impact of boundary layer mixing processes on local air quality and to validate the large eddy simulation …

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The Inhibitory Mechanism of Sars-Cov-2 by Small Molecules of the Condensed Amino Thiourea Scaffold Based on Molecular Dynamics Simulation

Xiaoli Shen, Hao Zhang, Pengyin Zhang, Xuerui Zhao et autres

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Insight into the Inhibitory Mechanism of Embryonic Ectoderm Development Subunit by Triazolopyrimidine Derivatives as Inhibitors through Molecular Dynamics Simulation

Jianan Ju, Hao Zhang, Shanshan Guan, Chang Liu et autres

(PRC2) can inhibit tumor growth. In this paper, we selected six experimentally designed EED competitive Inhibitors of the triazolopyrimidine derivatives class. We investigated the difference in the binding mode of the natural substrate to the Inhibitors and the effects of differences in …

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