Li Li

Metagenomic sequencing reveals structural and functional differentiation of the rhizosphere bacterial communities associated with available potassium in Atractylodes lancea affected with root rot

Li Li, Ruibo Liu

Background Atractylodes lancea is an economically valuable medicinal herb indigenous to China, and its yield and quality are severely threatened by root rot disease. The rhizosphere microenvironment plays a critical role in plant health. Yet, its relationship with root rot in A. …

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Adult T-cell Leukemia/Lymphoma in Japan: Real-World Treatment Patterns, Healthcare Resource Utilization, and Costs

Charles Dharmani, Zahid Islam, Pingping Qu, Zoe Jiang et autres

Background: Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive type of peripheral T-cell malignancy caused by the human T-lymphotropic virus type 1 (HTLV-1). Approximately 5 to 10 million people are infected with HTLV-1 worldwide, with high prevalence in Japan. This observational …

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Adult T-cell Leukemia/Lymphoma in Japan: Real-World Treatment Patterns, Healthcare Resource Utilization, and Costs

Charles Dharmani, Zahidul Islam, Pingping Qu, Zoe Jiang et autres

Background: Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive type of peripheral T-cell malignancy caused by the human T-lymphotropic virus type 1 (HTLV-1). Approximately 5 to 10 million people are infected with HTLV-1 worldwide, with high prevalence in Japan. This observational …

us, jp (code pays fourni par la source)

NLRP12 in cancer: a context-dependent regulator of tumor progression, immunity, and metabolism

Yuting Cen, Li Li, Xinyu Ding, Chenyang Wang et autres

NLRP12, a member of the NOD-like receptor family, has traditionally been regarded as an inflammasome-associated regulator of inflammatory signaling. However, accumulating evidence indicates that its role in cancer extends far beyond classical inflammasome biology. Recent studies show that NLRP12 exerts highly context-dependent …

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Preclinical evaluation of the newly developed carina platform in robotic-assisted proctectomy with porcine and cadaveric models

Yifei Feng, Junwei Tang, Y Zhang, Di Zhang et autres

Robotic-assisted laparoscopic surgery has made progress in addressing many of the technical challenges associated with conventional laparoscopy. Recently, a new robotic surgical system, Carina Platform, has been developed. The aim of this study is to evaluate the feasibility and safety of Carina …

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Peripheral T-cell Lymphoma in Japan: Real-World Patient Characteristics, Treatment Patterns, Healthcare Resource Utilization, and Costs

Charles Dharmani, Oluwatosin Fofah, Pingping Qu, Zoe Jiang et autres

Background Peripheral T-cell lymphomas (PTCLs) are a rare and heterogeneous group of non-Hodgkin lymphomas associated with aggressive clinical course and suboptimal outcomes. PTCL accounts for a higher proportion of non-Hodgkin lymphoma cases in Japan compared with Western countries; however, real-world evidence on …

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Safety and Efficacy of Satralizumab in Patients with Relapsing Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD): Results from the Phase 3 METEOROID Trial (PL5.006)

Michael Levy, Eoin Flanagan, Tania Kümpfel, Romain Marignier et autres

To report primary and key secondary efficacy and safety results of the Phase 3 METEOROID (NCT05271409) study investigating satralizumab in patients with MOGAD.

us, de, fr, jp, gb, ch, se, cn (code pays fourni par la source)

Real-world effectiveness of rezvilutamide plus androgen deprivation therapy in patients with high-volume metastatic hormone-sensitive prostate cancer: a retrospective multicenter cohort study

Bo Wang, Dan Xia, Yu Pan, J B Hu et autres

Background: Rezvilutamide has demonstrated significant clinical benefits in patients with high-volume metastatic hormone-sensitive prostate cancer (mHSPC) in the phase III CHART study. However, patients enrolled in clinical trials may not fully represent those encountered in routine clinical practice, and real-world evidence in …

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Metagenomic sequencing reveals structural and functional differentiation of rhizosphere bacterial communities driven by nitrogen and potassium deficiency associated with root rot of Schisandra chinensis

Li Li, Ruibo Liu, Hao Yang, Yongping Zhao

Background Frequent incidence of root rot in Schisandra chinensis impairs its yield and quality, yet the rhizosphere microecological mechanism driving this incidence remains unclear. Methods To clarify this mechanism, healthy and root rot-infected S. chinensis plants were analyzed in this study. The …

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Machine learning predictions surpass individual mRNAs as a proxy of single-cell protein expression

Oliver Wood, Samuel J. Bullers, Lynne A. Murray, Li Li et autres

BACKGROUND: Expansive repositories of scRNA-seq data are now available. These are often analysed assuming that mRNA abundance reflects expression of the cognate protein. However, post-transcriptional/translational regulation and the sparsity of measurements in single-cell data make mRNA an inadequate proxy for protein. Methods …

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Cost-Effectiveness of Sterile Cold Spray in Enhancing 12-Month Retention Rates Among First-Time Blood Donors: A Decision-Making Model Study for Blood Centres Based on Causal Mediation Analysis

Li Li, Lei Zhao, Zubing Zhang, Qinson Zhang et autres

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Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang et autres

BACKGROUND: This study investigated the role of polydatin in regulating macrophage-epithelial cell (EC) interactions during asthma. An asthma model was induced in BALB/c mice using ovalbumin (20 μg). METHODS: The therapeutic effects of polydatin (20 and 40 mg/kg) were evaluated in this …

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