Junwei Tang

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou et autres

Colorectal cancer (CRC) remains a leading cause of cancer mortality, and the molecular drivers of progression and distant metastasis are incompletely understood. By integrating differential expression and survival analyses of TCGA CRC cohorts with HOX family genes, we identified HOXC11 as a …

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Preclinical evaluation of the newly developed carina platform in robotic-assisted proctectomy with porcine and cadaveric models

Yifei Feng, Junwei Tang, Y Zhang, Di Zhang et autres

Robotic-assisted laparoscopic surgery has made progress in addressing many of the technical challenges associated with conventional laparoscopy. Recently, a new robotic surgical system, Carina Platform, has been developed. The aim of this study is to evaluate the feasibility and safety of Carina …

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ENO2 drives tumor cell-induced M2 macrophage polarization to promote colorectal cancer liver metastasis

Junwei Tang, Zhihao Chen, Dongsheng Zhang, Kangpeng Jin et autres

Liver metastasis is the primary cause of mortality in colorectal cancer (CRC) patients. To decipher the underlying mechanisms, we performed single-cell RNA sequencing (scRNA-seq) on paired primary colorectal tumors, adjacent tissues and liver metastases from three CRC liver metastasis (CRLM) patients, alongside …

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Total neoadjuvant chemotherapy combined with PD‑1 blockade and IL‑2 in MSS/pMMR locally advanced rectal cancer: short-term results of a prospective, single-arm phase II study

Junwei Tang, Lu Wang, Sheng Yang, Wen Peng et autres

Neoadjuvant therapy has become a cornerstone in the management of locally advanced rectal cancer (LARC). In this single-arm, open-label phase II study, we evaluated the efficacy and safety of total neoadjuvant chemotherapy (TNT) using a CapOX regimen combined with a programmed cell …

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An efficient transformation and gene editing system for Lilium species

Yajie Zhao, Yixuan Li, Jinxin Shi, Yutong Chen et autres

A transformation system exploits lily bulb scale propagation and de novo formation of bulblets, integrating tissue culture with non-tissue culture approaches. Through optimized scale propagation and disinfection treatments, it achieves efficient stable gene overexpression and editing in lily. Lilium spp. are globally …

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High-concentration co-application of 2,3-Butanedione monoxime and gibberellic acid synergistically promote dormancy release and improve post-planting agronomic traits in lily bulbs

Jinlong Li, Jing Dong, J. M. Yan, Yajie Zhao et autres

Dormancy regulation is a major challenge for sustainable lily ( Lilium spp.) production, as incomplete or prolonged dormancy release impacts vegetative growth and flowering. Gibberellic acid (GA) is widely used to promote dormancy release, whereas 2,3-Butanedione monoxime (BDM), a plasmodesmata regulator, has …

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Gibberellin modulates the post‐transcriptional regulation of CsHDZ34 to positively regulate bud break in tea plants

C. I. Huang, Junwei Tang, Wenqing Sun, Mengmeng Huang et autres

Summary Sprouting, an important process in plant growth and development, is economically critical for the tea plant ( Camellia sinensis (L.) O. Kuntze) and other horticultural crops, in which tender spring shoots constitute the primary harvest. While gibberellin's (GA) role in plant …

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Association of Mesenteric Molding Suturing on Parastomal Hernia Incidence: Retrospective Study

Junwei Tang, Lu Wang, Dongjian Ji, Jie Du et autres

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FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Hongxu Nie, Hengjie Xu, Sheng Yang, Tuo Wang et autres

Emerging evidence highlights the role of SCF E3 ligases, consisting of SKP1, cullin-1, and F-box proteins, in cancer biology by regulating the ubiquitination and degradation of key proteins. This study identifies F-box only protein 44 (FBXO44) as an oncogene in colorectal cancer …

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Genomic and Clinical Predictors of Conversion in Initially Unresectable Colorectal Cancer Liver Metastases

Daocheng Zuo, Lu Wang, Kangpeng Jin, Yue Zhang et autres

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Insights into soil carbon metabolism and carbon sequestration capacity under organic fertilizer substitution model

Zirui Zhou, Yan Liao, Qian Zhang, Junwei Tang et autres

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Natural variation of CsUGT71A60 determines growth and cold tolerance via regulating cytokinin glycosylation in Camellia sinensis

Mingyue Zhao, Jingming Wang, Xinyuan Hao, Jieyang Jin et autres

Cold stress severely limits tea plant (Camellia sinensis) productivity, yet the molecular mechanisms underlying cold adaptation remain elusive. Here, we identified a cold-inducible glycosyltransferase, CsUGT71A60, through integrative genome-wide association studies (GWAS) and proteomic profiling. Natural variation in CsUGT71A60 was strongly associated with …

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