Liying Zhang

Scalable and Generalizable Analog Design via Learning Medicinal Chemistry Intuition from Matched Molecular Pair Transformations

Hao‐Wei Pang, Peter Zhiping Zhang, Bo Pan, Liang Zhao et autres

Chemical analog design in the hit-to-lead and lead optimization stages of drug discovery relies on systematic structural modifications, often guided by medicinal chemistry intuition. Although a matched molecular pair (MMP) provides an interpretable framework to capture intuition, models trained on individual MMP …

us (code pays fourni par la source)

HELMify: A Hybrid Rule- and LLM-Based Generator of Peptide Monomer HELM Names

Robert P. Sheridan, Rajvi Shah, Kathryn Mcgarty, Michael Garrigou et autres

HELM is a hierarchical notation system for biopolymers that is an increasingly popular choice for representing peptides. In this system, each monomer name must uniquely identify a single monomer, and until now, chemists have named peptide monomers by hand using a limited …

us (code pays fourni par la source)

DA-ECAN: DualAudio-EnhancedCNN feature learning with asymmetric fusion for multimodal emotion recognition

Liying Zhang, Tianbo Zou, Lumeng Chen, Zi Wang et autres

cn (code pays fourni par la source)

Far Infrared Radiation Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Modulation of the p53/TGF-β Signaling Pathway

Jicheng Li, Jingxu Chang, Wenhan Chu, Yu Jiang et autres

Currently, there is no curative medication for idiopathic pulmonary fibrosis (IPF), and therapeutic interventions for IPF are hindered by limited efficacy and severe adverse side effects. Far Infrared Radiation (FIR), an invisible form of electromagnetic energy, has garnered increasing attention for its …

cn (code pays fourni par la source)

TailorNet: An Adaptive Collaborative Learning Framework for Imbalanced Multi-Relational Graphs via Tail Node Enhancement

Jingyu He, Liying Zhang

Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma

Hao Dong, Kaixuan Sun, Xuejie Wang, Meimei Cui et autres

Uncoupling protein-2 (UCP2) controls the antioxidant response and redox homeostasis in cancer and is considered a potent molecular target for cancer treatment. However, the specific mechanism of UCP2 inhibition and its role in glioblastoma (GBM) have not yet been elucidated. Here, we …

cn (code pays fourni par la source)

Deep Fusion Multi-View Hashing for Multimedia Retrieval

Jian Gang Zhu, Mingkai Sheng, Mingda Ke, Wen Ming Cheng et autres

Multi-view hash representation learning is a crucial technique for multimedia retrieval. However, current methods have limitations in integrating the features of multiple views, leading to limited retrieval accuracy. Most studies use fusion methods such as weighted sum or concatenation, which fail to …

cn (code pays fourni par la source)

Development of Automotive Components Detection Experiment System Based on Machine Vision

Xuejun Li, Liyan Li, Liying Zhang, Dong Pan et autres

Automatic detection technology based on machine vision is one of the key technologies in intelligent manufacturing. To meet the demand of the online automatic detection of automotive components, a machine vision-based detection system is designed. The system is composed of machine vision, …

cn, us (code pays fourni par la source)

Dynamic Dark Channel Prior Dehazing with Polarization

Haotong Suo, Jinge Guan, Miao Ma, Yongsheng Huo et autres

For traditional dark channel prior (DCP) imaging through haze environments, intensity information acts as the carrier to acquire the reflective character of the dehazed target image. We introduce polarization as auxiliary information into the traditional DCP dehazed process for achieving better imaging …

cn (code pays fourni par la source)

Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13

Shenping Liu, Ruth F. Sommese, Nicole L. Nedoma, Lucy M. Stevens et autres

Abstract Hydroxysteroid 17-beta-dehydrogenase 13 (HSD17B13) is a hepatic lipid droplet-associated enzyme that is upregulated in patients with non-alcoholic fatty liver disease. Recently, there have been several reports that predicted loss of function variants in HSD17B13 protect against the progression of steatosis to …

us, ch (code pays fourni par la source)

CDF-LS: Contrastive Network for Emphasizing Feature Differences with Fusing Long- and Short-Term Interest Features

Kejian Liu, Rongju Wang, Xuran Cui, Liying Zhang et autres

Modelling both long- and short-term user interests from historical data is crucial for generating accurate recommendations. However, unifying these metrics across multiple application domains can be challenging, and existing approaches often rely on complex, intertwined models which can be difficult to interpret. …

cn (code pays fourni par la source)

CDF-LS:Contrastive Network for Emphasizing Feature Differences with Fusing Long and Short-term Interest Features

Kejian Liu, Rongju Wang, Xuran Cui, Liying Zhang et autres

Modelling both long and short-term user interests from historical data is crucial for accurate recommendations. However, unifying these metrics across multiple application domains can be challenging, and existing approaches often rely on complex, intertwined models which can be difficult to interpret. To …

cn (code pays fourni par la source)