Wenbo Wang

[Retracted] GDC‑0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway

Lin Yang, Taipengfei Shu, Yingjian Liang, Wenguang Gu et autres

, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a reply. The Editor apologizes to the readership for …

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Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils

Hayato Etani, Sho Takatori, Wenbo Wang, Jumpei Omi et autres

BACKGROUND: Microglia play a crucial role in brain homeostasis through phagocytosis of amyloid-β (Aβ) fibrils, a hallmark of Alzheimer disease (AD) pathology. The balance between Aβ production and clearance is critical for AD pathogenesis, with impaired clearance mechanisms potentially contributing to disease …

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Engineered Titanium Oxide Nanoplatform for Targeted Photodynamic/Photothermal-Gas Therapy in Keloid Treatment

Wufei Dai, Zhengjie Huang, Qinglin Li, Wenbo Wang et autres

Keloids pose a considerable worldwide health issue owing to their continual proliferation, invasiveness, and elevated recurrence rates. Keloids are abnormal scars formed through dysregulated wound healing processes, characterized by excessive keloid fibroblast (KF) proliferation, irregular collagen deposits, and persistent reticular dermis inflammation, …

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Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA/NF-κB signaling pathway

Rongbao Yan, Ye Yuan, Ce Shi, Li Yang et autres

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The inhibitory effect of type V transforming growth factor-β receptor antagonist on the proliferation of keloid fibroblasts by suppressing insulin-like growth factor-binding protein 3-interleukin-6 signaling

Boya Zhou, Xunxun Lin, Lingling Xia, Zhen Gao et autres

Abstract Background: Hyperplasia of fibroblasts is critical in keloid pathogenesis. Insulin-like growth factor-binding protein 3 ( IGFBP3 ) is an important factor in the regulation of cell growth and type V transforming growth factor-β receptor (TβR-V) is a specific receptor of IGFBP3 …

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Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils

Hayato Etani, Sho Takatori, Wenbo Wang, Jumpei Omi et autres

Abstract Microglia, the primary immune cells of the central nervous system, play a crucial role in maintaining brain homeostasis through phagocytosis of various substrates, including amyloid-β (Aβ) fibrils, a hallmark of Alzheimer disease (AD) pathology. However, the molecular mechanisms regulating microglial Aβ …

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Platelet-rich plasma-derived extracellular vesicles inhibit NF-κB/NLRP3 pathway-mediated pyroptosis in intervertebral disc degeneration via the MALAT1/microRNA-217/SIRT1 axis

Xueqiang Tao, Fen Xue, Jiayuan Xu, Wenbo Wang

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Development of a novel bispecific antibody GR1801 for rabies

Caifeng Long, Wenbo Wang, Xiaobo Hao, Chuanfei Yu et autres

Rabies is a zoonotic viral disease characterized by an almost 100% fatality rate once symptoms appear. However, it can be prevented through timely postexposure prophylaxis (PEP). Currently, there is a growing trend to replace polyclonal rabies immune globulin (RIG) with monoclonal antibodies …

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CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway

LI Yu-jie, Wenbo Wang

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines

Siqi Shang, Yunshuo Chen, Xuejiao Yang, Ying Yang et autres

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RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines

Siqi Shang, Yunshuo Chen, Xuejiao Yang, Ying Yang et autres

Abstract Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell therapy can lead to immunotherapy-associated side effects including cytokine release syndrome and neurotoxicity. Gene depletion of GM-CSF in CAR-T cells …

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Combination of Expanded Allogeneic NK Cells and T Cell-Based Immunotherapy Exert Enhanced Antitumor Effects

Xiao Wang, Xuejiao Yang, Yueping Wang, Yunshuo Chen et autres

Immunotherapies based on immune checkpoint blockade, neoantigen-reactive tumor-infiltrating lymphocytes and T cell receptor-engineered T cells (TCR-T) have achieved favorable clinical outcomes in tumor treatment. However, sustained immune response and tumor regression have been observed only in a few patients due to immune …

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