Yunshuo Chen

G20 Country Burden of High BMI-Related Liver Cancer: Trends from 1990 to 2021 and Projections to 2050

Yunshuo Chen, Meiling Huang, Yuanjia Huang

BACKGROUND: Liver cancer associated with a high body mass index (BMI) poses a significant global health challenge, particularly within G20 nations characterized by elevated rates of Hepatitis B and C infections. This study aims to quantify the burden of liver cancer attributable …

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Dinotefuran exposure induces immunotoxicity in zebrafish embryos

Yunshuo Chen, Dan Li, Weiwei Feng, Yao Chen et autres

As a typical neonicotinoid insecticide, dinotefuran (DIN) has immunotoxicity, but its immunotoxicity effects on aquatic organisms and its molecular mechanisms are not known. In this study, zebrafish embryos were used as model to reveal its immunotoxicity and its mechanism from the perspective …

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DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming

Xuejiao Yang, Xiao Wang, Ying Yang, Zhiyang Li et autres

BACKGROUND: DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogenesis through hypomethylation of some target genes associated with cell …

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RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines

Siqi Shang, Yunshuo Chen, Xuejiao Yang, Ying Yang et autres

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RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines

Siqi Shang, Yunshuo Chen, Xuejiao Yang, Ying Yang et autres

Abstract Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell therapy can lead to immunotherapy-associated side effects including cytokine release syndrome and neurotoxicity. Gene depletion of GM-CSF in CAR-T cells …

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Additional file 2 of DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming

Xuejiao Yang, Xiao Wang, Ying Yang, Zhiyang Li et autres

Additional file 2: Table S2. The mRNA expression level of NAMPT in AML obtained from the Oncomine database.

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Combination of Expanded Allogeneic NK Cells and T Cell-Based Immunotherapy Exert Enhanced Antitumor Effects

Xiao Wang, Xuejiao Yang, Yueping Wang, Yunshuo Chen et autres

Immunotherapies based on immune checkpoint blockade, neoantigen-reactive tumor-infiltrating lymphocytes and T cell receptor-engineered T cells (TCR-T) have achieved favorable clinical outcomes in tumor treatment. However, sustained immune response and tumor regression have been observed only in a few patients due to immune …

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NAM-NAD+-ADO metabolic reprogramming is a key factor for DNMT3A mutation to promote leukemia development through regulating cell cycle and immune microenvironment

Yueying Wang, Xuejiao Yang, Xiao Wang, Ying Yang et autres

Abstract DNMT3A-R882H mutation is a frequent epigenetic mutation in acute myeloid leukemia (AML)-M4 and M5, participating in the regulation of cell growth and differentiation by blocking the binding of transcription factor complexes to DNA. However, effective approaches that directly target this inactivating …

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Research on Site Planning of Mobile Communication Network

Yunshuo Chen, Fanqiang Fu

With the development of 5G technology, network communication has become the most commonly used tool in People’s Daily life and production. Due to the huge user base, the problem of site selection of communication network has become more and more complex. This …

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Melatonin-Medicated Neural JNK3 Up-Regulation Promotes Ameloblastic Mineralization

Qianhui Ren, Jing Pan, Yunshuo Chen, Zhecheng Shen et autres

Introduction: Melatonin, an endogenous neurohormone, modulates the biological circadian rhythms of vertebrates. It functions have been reported in previous stomatological studies as anti-inflammation, antioxidant, osseointegration of dental implants and stimulation to dental pulp stem cells differentiation, but its role in ameloblastic differentiation …

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Therapeutic Potential of TNFα and IL1β Blockade for CRS/ICANS in CAR-T Therapy via Ameliorating Endothelial Activation

Yunshuo Chen, Ranran Li, Siqi Shang, Xuejiao Yang et autres

Severe cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) strongly hampered the broad clinical applicability of chimeric antigen receptor T cell (CAR-T) therapy. Vascular endothelial activation has been suggested to contribute to the development of CRS and ICANS after …

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Impact of blood count recovery on outcomes of acute myeloid leukemia patients achieving morphologic leukemia-free state

Wenyan Cheng, Yongmei Zhu, Zhao Liu, Xiangqin Weng et autres

Acute myeloid leukemia (AML) is a group of heterogeneous hematological malignancies. Clinical features such as age, performance status, and cytogenetic and molecular abnormalities at diagnosis are all pre-treatment prognostic factors. In recent years, post-treatment parameters including minimal residual disease (MRD) and blood …

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