Yihan Zhang

Super-enhancer-driven SGK1 activates polyamine metabolism to promote autoimmune uveitis.

He Li, Lei Zhu, Zhaohuai Li, Genxian Zhang et autres

) balance, whereas polyamine supplementation negates these therapeutic benefits, confirming SGK1's role in driving disease progression. Notably, through molecular docking and molecular dynamics simulations, we identified herbacetin as a natural inhibitor of SGK1. Herbacetin restores immune balance and mitigates disease severity, highlighting …

cn (code pays fourni par la source)

ENSO-related variability in typhoon-induced high-wave exposure along the Guangdong coast

Lei Li, Ming Zhang, Mengfei Zhang, Hongwei Liu et autres

Typhoon-generated high waves are a recurrent coastal hazard along Guangdong, southern China, however, the extent to which the El Niño–Southern Oscillation (ENSO) can inform annual-scale coastal exposure remains uncertain. This study integrates hourly ERA5 wave and wind data (1979–2025) from six coastal-shelf …

us, cn, bg, ru (code pays fourni par la source)

Socioeconomic Development, COVID-19, and Visual Health in Chinese Youth: A 30-Year Trend and Frontier Analysis of the Burden of Blindness Due to Refractive Error

Yihan Zhang, Qixuan Tang, Shenyu Wang, Jiaying Liu et autres

PURPOSE: To evaluate long-term trends of refractive error-related blindness in Chinese children and adolescents (1990-2021) and project future trajectories to 2035, assessing impacts of COVID-19 and socioeconomic development. METHODS: Retrospective and predictive analysis using Global Burden of Disease (GBD) 2021 data. Primary …

cn (code pays fourni par la source)

Fluoropolymer‐Mediated Delivery of a Dual TSHR/IGF1R‐Targeting CRISPR‐Cas9 System for Localized Therapy in Thyroid‐Associated Ophthalmopathy

Mingsu Shi, Panting Yu, Lingyun Liu, Jinwei Cheng et autres

Thyroid-associated ophthalmopathy (TAO), a vision-threatening and disfiguring autoimmune orbital disorder, remains a therapeutic challenge due to the lack of therapies with orbital specificity, sustained efficacy, and minimal side effects. Herein, we present G4F7-CRISPR, a fluoropolymer-based CRISPR-Cas9 delivery platform engineered for localized and …

cn (code pays fourni par la source)

Single-Cell RNA sequencing identifies NAMPT as a potential therapeutic target in autoimmune uveitis

Yingying Wen, Lei Zhu, Zhaohao Huang, Genxian Zhang et autres

• Inhibition of NAMPT significantly ameliorates both the clinical symptoms and histopathological features of EAU. • NAMPT inhibition reverses abnormal, disease-associated transcriptional programs within immune cell populations in EAU, particularly in CD4 + T cells. • Suppressing NAMPT reduces Th17 and Th1 …

cn (code pays fourni par la source)

Neuropsychologic impact of MOGAD: A patient reported outcomes study

Bruna Leles Vieira de Souza, Yihan Zhang, Philippe‐Antoine Bilodeau, Anastasia Vishnevetsky et autres

us (code pays fourni par la source)

Intravenous Multifunctional Nanotherapy for Treating Dry Age‐Related Macular Degeneration (Adv. Healthcare Mater. 29/2025)

Xinyi Zhao, Weiyi Xia, Hongjian Wang, Yihan Zhang et autres

Age-Related Macular Degeneration Like hot-air balloons delivering cargo, the multifunctional micellar system, APMNP@Rapa, specifically targets damaged retinal pigment epithelium (RPE) in dry AMD and releases therapeutic payload in response to high ROS levels. By coordinately attenuating oxidative damage, suppressing inflammation, and inhibiting …

Breastfeeding difficulties and maternal mental health: role of social support in rural northwestern China

Jie Yang, Yunjie Liu, Xu Zhang, Yihan Zhang et autres

BACKGROUND: Globally, escalating mental health issues among postpartum women underscore their significant impact on individuals, children, and society. This study investigates the associations between breastfeeding difficulties and maternal mental health in rural areas of northwestern China. Additionally, we examine how mothers' perceived …

cn, ca (code pays fourni par la source)

A Multi‐Center Retrospective Cohort Study of Neurosarcoidosis Myelitis: Current Observations and Future Directions

Giovanna S. Manzano, Denis Balaban, Yihan Zhang, Brian C. Healy et autres

ABSTRACT Objective The optimal treatment for neurosarcoidosis myelitis is uncertain. We characterize incident neurosarcoidosis myelitis and assess treatment response by MRI and clinical scales. Methods Incident probable or definite neurosarcoidosis myelitis in adults was retrospectively identified from 13 academic medical centers. Cases …

us, pr (code pays fourni par la source)

Associations of Physical Frailty, Social Deficits, and Cognitive Impairment with Risk of 45 Incident Non-Communicable Diseases: The Mediating Role of Accelerated Biological Aging—A Prospective Cohort Study

Bing Pei, Yue Yu, Xinyuan Shen, Yanjie Jia et autres

Objectives Frailty extends beyond a physical construct to encompass cognitive and social functioning. We aimed to assess the associations of these impairments, individually and in combination, with the risk of 45 non-communicable diseases (NCDs), and explore the role of accelerated biological aging. …

cn (code pays fourni par la source)

Intravenous Multifunctional Nanotherapy for Treating Dry Age‐Related Macular Degeneration

Xinyi Zhao, Weiyi Xia, Yu Wang, Yihan Zhang et autres

Abstract Retinal pigment epithelium (RPE) degeneration is the pathological hallmark of multifactorial dry age‐related macular degeneration (dAMD). Mounting evidence implicates oxidative stress and aberrant activation of mammalian target of rapamycin (mTOR) as key drivers of this process. Recent studies have shown that …

cn, us (code pays fourni par la source)

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang et autres

Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single-cell RNA sequencing (scRNA-seq) are performed in patients with BU and healthy controls …

cn (code pays fourni par la source)