Zhaohuai Li

Upadacitinib Restrains the Pathogenic Fitness of CD4 + T Cells and Aberrant B Cell Programming in Optic Neuritis

G H Jiang, Qi Jiang, Lian Han, Yue Peng et autres

ABSTRACT Optic neuritis (ON) is a neuroinflammatory autoimmune disease harboring autoreactive lymphocytes. Effector memory CD4 + T cells (CD4 + T em ) represent a prominently expanded and pro‐inflammatory subset within this compartment, yet their pathogenic metabolic programs remain poorly defined. B …

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Twenty‐Minute Microwave‐Enabled Dual‐Anion Nickel Sulfoselenide Anodes for High‐Capacity Sodium/Potassium‐Ion Batteries and Durable Pouch Cells

Yayun Zheng, Qiu He, Jitao Shang, Shasha Wei et autres

Nickel‐based materials are promising anode candidates for sodium‐ion batteries and potassium‐ion batteries due to their high theoretical capacities. However, their practical application is hindered by slow ion diffusion kinetics and structural degradation during cycling, resulting in rapid capacity decay. To address these …

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Synergistic bulk and interface modification via lanthanization enhances structural stability and ion kinetics in O3-NaNi 1/3 Fe 1/3 Mn 1/3 O 2 cathodes

Yunan Tian, Xiangxin Cheng, Weimin Chen, Bo Han et autres

This work simultaneously constructs a lanthanide-based surface layer and achieves gradient La 3+ doping in NaNi 1/3 Fe 1/3 Mn 1/3 O 2 (NFM), leading to remarkable improvements in both rate capability and cycling stability.

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Nano‐Confined Synergistic Conduction Enables Electrolytes for All‐Solid‐State Lithium Metal Batteries

Chi Han, Huasen Shen, Mengjun Li, Yunan Tian et autres

Abstract An ultrathin (15 µm) composite polymer solid‐state electrolyte is engineered by embedding a dual‐polymer matrix (PEO/PVDF‐HFP) and nano‐LATP particles within a negatively charged nanofiber scaffold (PPLNF). This architecture enables a nano‐confined synergistic conduction (NCSC) mechanism, which electrostatic repulsion from functionalized pore …

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Regulation of Interfacial Ion Transport via Honeycomb‐Architected Covalent Organic Frameworks for Lithium Metal Batteries

Yuxuan Chen, Jie He, Mengjun Li, Huasen Shen et autres

Abstract This study pioneers vertically aligned honeycomb covalent organic framework (HCCOF) on graphene oxide (HCCOF‐GO) through one‐pot colloidal assembly, establishing a paradigm for interface‐engineered 2D heterostructures in lithium metal batteries (LMBs). Mechanistically, the vertical COF alignment via interfacial π–π conjugation preserves intrinsic …

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Industrializable interlayer with catalytic conversion of dead lithium for Ah–level Nickel–rich lithium metal batteries

Huasen Shen, Zhaohuai Li, Jiantao Li, Qiu He et autres

The growth of lithium (Li) dendrites and the accumulation of dead Li (i.e., Li metal regions which are electronically disconnected from the current collector) significantly undermine the safety and performance of Li metal batteries. This study employs kilogram–scale atomic layer deposition technology …

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Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang et autres

Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and single-cell RNA sequencing (scRNA-seq) are performed in patients with BU and healthy controls …

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MOF-derived pearl-like nanospheres enable tailored regulation of interface ion transport in dendrite-free lithium metal batteries

Xiaoxin Wu, Si Chen, Huasen Shen, Yunan Tian et autres

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Lithiophilic Interlayer with Electrolyte-Reservoir and Dendrite-Buffer for High-Performance Lithium Metal Batteries

Huasen Shen, Guoning Wu, Tingting Ma, Mengjun Li et autres

Uneven local electric fields and limited nucleation sites at the reaction interface can lead to the formation of hazardous lithium (Li) dendrites, posing a significant safety risk and impeding the practical utilization of Li metal anodes (LMAs). Here, we present a method …

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20-Minute Microwave-Enabled Dual-Anion Nickel Sulfoselenide Anodes for High-Capacity Sodium/Potassium-Ion Batteries and Durable Pouch Cells

Yayun Zheng, Qiu He, Jitao Shang, Shasha Wei et autres

Nickel-based materials are promising anode candidates for sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) due to their high theoretical capacities. However, their practical application is hindered by slow ion diffusion kinetics and structural degradation during cycling, resulting in rapid capacity decay. To …

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Single-cell RNA sequencing indicates AP-1 as a potential therapeutic target for autoimmune uveitis

Sichen Zhao, Dongting Wu, Yao Lu, Lei Zhu et autres

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Mof-Derived Pearl-Like Nanospheres Enable Tailored Regulation of Interface Ion Transport in Dendrite-Free Lithium Metal Batteries

Zhaohuai Li, Xiaoxin Wu, Si Chen, Mengjun Li et autres