Hao Li

N-Nitrosamine Quantitation in Pharmaceuticals by Tandem Mass Spectrometry

Mousumi Saha, Lingqi Qiu, Stefan Kraft, Daniel Lee et autres

The mutagenic potential of N -nitrosamines has heightened regulatory scrutiny and prompted numerous drug recalls due to their formation as impurities during pharmaceutical manufacturing. However, the simultaneous and rapid analysis of multiple N -nitrosamines remains challenging. In this study, we show a …

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Author response for "4,4′-Dimethyl-1,1′-bi(1,2,3-triazole): exploring new insensitive energy source materials"

Hao Li, Guangyuan Zhang, Ning‐Ning Du, Le‐Wu Zhan et autres

Biochemical and Structural Characterization of a Highly Glucose-Tolerant β-Glucosidase from the Termite Reticulitermes perilucifugus

Guotao Mao, Ming Song, Hao Li, Kai Wang et autres

The enzymatic hydrolysis of lignocellulose is often hindered by the glucose-mediated inhibition of β-glucosidases, a major bottleneck in industrial cellulose degradation. Identifying novel glucose-tolerant β-glucosidases is essential for enhancing saccharification efficiency. In this study, we cloned and heterologously expressed a novel β-glucosidase, …

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Metal-organic framework derivatives with complex architectures: Controllable synthesis and applications

Guangxun Zhang, Hao Li, Qiujing Wang, Yichun Su et autres

Metal–organic frameworks (MOFs), which are porous crystal materials with a large surface area and high porosity, have been extensively studied. MOF derivatives with complex structures, including hollow, porous, core-shell, yolk-shell, multi-shell and array structures, have garnered significant attention in the fields of …

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4,4′-Dimethyl-1,1′-bi(1,2,3-triazole): exploring new insensitive energy source materials

Hao Li, Guangyuan Zhang, Ning‐Ning Du, Le‐Wu Zhan et autres

One step oxidation in a long nitrogen chain compound with good detonation properties.

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Facile synthesis of Bis(1,2,3-triazole) and 1,1’-azobis-1,2,3-triazole via divergent one-step oxidation of glyoxal dihydrazone

Hao Li, Jing Wei Hou, Jun-Yue Wu, Guangyuan Zhang et autres

Here we present a novel divergent one-step oxidation strategy for the synthesis of bis(1,2,3-triazole) and 1,1’-azobis-1,2,3-triazole using readily available glyoxal dihydrazone as the starting material. Using MnO2 as the oxidant, bis(1,2,3-triazole) could be obtained in 50% yield employing CCl4 as solvent at …

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The effect of halides on Cd(II)-based metal coordination complexes with indazole and benzimidazole skeletons: Crystal structure, Hirshfeld surface analysis and properties

Hao Li, Si-Jiao Yang, Ming-Yu Dong, Gui‐Mei Tang et autres

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Mechanism of Nitrone Formation by a Flavin-Dependent Monooxygenase

Sydney B. Johnson, Hao Li, Hannah R. Valentino, Pablo Sobrado

OxaD is a flavin-dependent monooxygenase (FMO) responsible for catalyzing the oxidation of an indole nitrogen atom, resulting in the formation of a nitrone. Nitrones serve as versatile intermediates in complex syntheses, including challenging reactions like cycloadditions. Traditional organic synthesis methods often yield …

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Identification and enrichment of a UV-induced degradant of Anagrelide drug substance

Hao Li, James Ehnstrom, Mark Milton, Webster L. Santos et autres

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A NIR emission fluorescence probe for visualizing elevated levels of SO2 in cancer cells and living tumor

Hao Li, Lizhou Yue, Huawei Huang, Zehua Chen et autres

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Menisperdaurines A-W, structurally diverse isoquinoline alkaloids from Menispermum dauricum and their dopamine D1 receptor activities

Hongli Wei, Yaopeng Zhao, Jixia Wang, Yang Han et autres

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Metabolomic Characterization of Fatty Acids in Patients With Coronary Artery Ectasias

Tianlong Liu, Yingying Sun, Hao Li, Haochen Xu et autres

Background: We used a targeted metabolomics approach to identify fatty acid (FA) metabolites that distinguished patients with coronary artery ectasia (CAE) from healthy Controls and patients with coronary artery disease (CAD). Materials and methods: Two hundred fifty-two human subjects were enrolled in …

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