Tingting Zhang

Efficacy of PD-1 inhibitor plus induction chemotherapy for nasopharyngeal carcinoma with high-grade extranodal extension: a multicenter retrospective analysis

Pingting Zhou, Shuang Huang, Yunxiu Luo, Yuefeng Hu et autres

BACKGROUNDS: High-grade radiologic extranodal extension (G2/3-rENE) is a well-established adverse prognostic factor in nasopharyngeal carcinoma (NPC), as demonstrated in our previous research. This study aims to evaluate the efficacy and safety of combining a PD-1 inhibitor with induction chemotherapy (IC) in this …

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177. A Rare but Critical Cause of Adolescent Hyperandrogenism: Sertoli–Leydig Cell Tumor Associated with DICER1 Mutation

Yilin He, Shuxing Yang, Tingting Zhang, He Huang et autres

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The real-world safety profile of ranolazine: pharmacovigilance analysis of the FAERS database

Zujun Wen, Xiang Liu, Yan Yi, Guoshun Lin et autres

Background: Ranolazine, a piperazine derivative, is used as a second-line treatment for individuals with stable or poorly managed chronic angina as well as for those whose chronic angina is not improving with other medications. However, there is still a lack of real-world …

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Primary pancreatic lymphoma masquerading as pancreatic carcinoma: A case report and literature review

Xingdong Xu, Tingting Zhang, Jinyu Liu, Xingzi Li et autres

RATIONALE: Primary pancreatic lymphoma (PPL), representing 0.5% of pancreatic malignancies, poses diagnostic challenges due to overlapping clinical and imaging features with pancreatic adenocarcinoma. PPL is diagnosed by obtaining tissue samples via endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) or explorative laparotomy with biopsy. The …

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2173-LB: The Proteomic Analysis of Intermittent Fasting Alone or with GLP-1RA in NAFLD Rats

Yimin Shao, Tingting Zhang, Junqing Zhang

Introduction and Objective: Intermittent fasting (IF) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are promising therapeutic approaches for nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the therapeutic effects of alternate-day fasting (ADF) alone and in combination with liraglutide, and to …

MiR‐155‐5p Inhibits Multiple Myeloma Cell Malignancy and Tumorigenesis by Targeting JARID2 and Inactivating the TGFβ/SMAD2 Signaling

Yuan Yuan, Tingting Zhang, Pingping Zhang, Lili Han et autres

Multiple myeloma (MM) is a hematological malignancy characterized by the accumulation of malignant plasma cells in bone marrow and remains largely incurable. The study aimed to investigate the role of miR-155-5p in modulating malignant cellular behavior and tumorigenesis in MM. MiR-155-5p expression …

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Clinical characteristics and outcomes of patients with intrathyroidal thymic carcinoma (ITC): a retrospective cohort study

Tingting Zhang, Xiang Geng, Qinghai Ji, Tuanqi Sun et autres

Background: Intrathyroidal thymic carcinoma (ITC) is an extremely rare type of thyroid cancer with very limited knowledge of its clinical characteristics and optimal treatment modalities. We aimed to assemble the largest ITC cohort to date for a better understanding. Methods: We collected …

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Exploring the mechanism of the potential effects of Liujunzi Tang combined with Suanzaoren Tang in the treatment of lung cancer with insomnia based on network pharmacology and molecular docking technology

Yaoyao Wang, Xin Zhao, Xiaomei Wang, Xuemei Wang et autres

This study explores the potential mechanisms of Liujunzi Tang combined with Suanzaoren Tang in treating lung cancer with insomnia through network pharmacology and molecular docking methods. In the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, each single herb in the formula of …

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Integrative analysis of single-cell and bulk RNA sequencing reveals the oncogenic role of ANXA5 in gastric cancer and its association with drug resistance

Denggang Chen, Peng Zhang, Li Gong, Hailang Wei et autres

Background: Gastric cancer (GC) remains a leading cause of cancer-related mortality, with over one million new cases and 769,000 deaths reported in 2020. Despite advancements in chemotherapy, surgery, and targeted therapies, delayed diagnosis due to overlooked early symptoms leads to poor prognosis. …

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The Expression and Clinical Significance of SARM1 in Newly Diagnosed Acute Myeloid Leukemia

Ning Ding, Yuanyuan Tan, Tingting Zhang, Meng-Meng Zhang et autres

BACKGROUND: This study aimed to evaluate the expression level of SARM1 in the bone marrow of patients with newly diagnosed acute myeloid leukemia (AML) and assess its clinical and prognostic significance. METHODS: Bone marrow specimens were collected from 60 patients with newly …

Identification of KLHL35, WDR72, and WDR78 as Prognostic Biomarkers in Colorectal Cancer

Jiayou Ye, Tingting Zhang, Guangsheng Wang, Aijun Chen et autres

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Adipsin improves diabetic hindlimb ischemia through SERPINE1 dependent angiogenesis

Xiaohua Zhang, Mengyuan Jiang, Xuebin Zhang, Yixuan Zuo et autres

BACKGROUND: Adipsin (complement factor D, CFD), as the first described adipokine, is well-known for its regulatory effects in diabetic cardiovascular complications. However, its role in diabetic hind-limb ischemia was not clarified. This study aimed to evaluate the possible therapeutic effect of Adipsin …

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