Rong Wang

lncRNA-miRNA-mRNA Network Analysis and Downstream Proteins Reveal the Mechanism of Bushen Huatan Prescription in the Treatment of Polycystic Ovary Syndrome

Wenting Xu, Lingli Shi, Xiuqin Tang, Rong Wang et autres

INTRODUCTION: Polycystic Ovary Syndrome (PCOS) is a prevalent reproductive endocrine disorder. The underlying mechanisms, particularly the role of the long non-coding RNA (lncRNA)- miRNA-mRNA network, remain incompletely understood. The Bushen Huatan (BSHT) prescription shows clinical efficacy in treating PCOS, but its active …

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Endoscopic variceal ligation combined with carvedilol versus endoscopic variceal ligation combined with propranolol for the treatment of oesophageal variceal bleeding in cirrhosis: study protocol for a multicentre, randomised controlled trial

Yiling Li, Li Du, Shuairan Zhang, Chuan Liu et autres

INTRODUCTION: Liver cirrhosis and its severe complication, oesophageal variceal bleeding (EVB), pose significant health risks. Standard treatment for EVB combines non-selective beta-blockers (NSBB) with endoscopic variceal ligation (EVL). Carvedilol, an NSBB with additional benefits, is preferred for compensated cirrhosis. However, no randomised …

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Melatonin alleviates ferroptosis triggered by cadmium via regulating ferritinophagy and iron metabolism in spermatogonia

Didi Jia, Wei Huang, Qizi Yin, Han Wang et autres

Melatonin (Mel), a classical antioxidant, has the potential to mediate ferroptosis. Cadmium (Cd) poses a substantial threat to the male reproductive system, as it can induce testicular injury by triggering ferroptosis. The study aimed to explore the protective role and mechanism of …

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Sequential drug release nanocomposites for synergistic therapy in disease treatment

Siyuan Luo, Chenyu Zhao, Rong Wang, Daocheng Wu

Time-sequenced drug release, or sequential drug release, represents a pivotal strategy in the synergistic treatment of diseases using nanocomposites. Achieving this requires the rational integration of multiple therapeutic agents within a single nanocomposite, coupled with precise time-controlled release mechanisms. These nanocomposites offer …

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Treatment with a combination of myricitrin and exercise alleviates myocardial infarction in rats via suppressing Nrf2/HO-1 antioxidant pathway

Feng-Xia Qu, Xiao Guo, Xiao‐Jun Liu, Shuwen Zhang et autres

Myocardial infarction (MI) is the primary source of death in cardiovascular diseases. Myricitrin (MYR) is a phenolic compound known for its antioxidant properties. This study aimed to investigate the impact of MYR alone or combined with exercise on a rat model of …

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PBA alleviates cadmium-induced mouse spermatogonia apoptosis by suppressing endoplasmic reticulum stress

Rong Wang, Mengyuan Li, Zhen Wu, Wenjing Gong et autres

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Wumei Wan attenuates angiogenesis and inflammation by modulating RAGE signaling pathway in IBD: Network pharmacology analysis and experimental evidence

Zheng-lan Duan, Yuji Wang, Zhihua Lü, Lin Tian et autres

BACKGROUND: Wumei Wan (WMW) has been used to address digestive disorder for centuries in traditional Chinese medicine. Previous studies have demonstrated its anti-colitis efficacy, but the underlying mechanism of its action remains to be further clarified. PURPOSE: To investigate the underlying mechanisms …

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Fertility Intentions, Parenting Attitudes, and Fear of Childbirth among College Students in China: A Cross-Sectional Study

Jing Xu, Lu Li, Xiaoqian Ma, Miao Zhang et autres

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Global Research Trends on Infertility and Psychology From the Past Two Decades: A Bibliometric and Visualized Study

Hongkun Zhu, Lingli Shi, Rong Wang, Lijuan Cui et autres

Objectives The aim of this study was to evaluate the global scientific output of research on infertility and psychology; explore the current status and trends in this field through the cooperation of authors, countries, and institutions; shed light on the direction of …

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Endostar Plus Apatinib Successfully Achieved Long Term Progression-Free Survival in Refractory Ovarian Cancer: A Case Report and Literature Review

Chunmei Xiao, Fangye Xu, Rong Wang, Qi Liang et autres

BACKGROUND: Ovarian cancer (OC) is a common malignancy in the gynecological tumor. Standard treatment for ovarian cancer is surgery and chemotherapy based on paclitaxel and platinum. However, traditional chemotherapy for ovarian cancer is limited by drug resistance and systemic side effects. It …

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Efficacy of Bushen Huatan Decoction combined with Baduanjin in the treatment of polycystic ovary syndrome with insulin resistance (IR-PCOS), kidney deficiency and phlegm dampness: study protocol for a randomized controlled trial

Haiqing Qian, Wenting Xu, Rong Wang, Jiahui Wang et autres

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women. Insulin resistance (IR) has emerged as a central contributor to the pathogenesis of this disease. According to traditional Chinese medicine (TCM), kidney deficiency is the main syndrome of PCOS. …

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Total flavone of Abelmoschus Manihot improves colitis by promoting the growth of Akkermansia in mice

Fan Bu, Yang Ding, Tuo Chen, Qiong Wang et autres

The total flavone of Abelmoschus manihot (TFA), a compound extracted from the flowers of Abelmoschus manihot (L.) Medic, has been widely used for the treatment of Crohn's disease, chronic glomerulonephritis and other diseases. The aim of this study was to investigate the …

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