Melatonin alleviates ferroptosis triggered by cadmium via regulating ferritinophagy and iron metabolism in spermatogonia
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Le résumé fourni par la source
Melatonin (Mel), a classical antioxidant, has the potential to mediate ferroptosis. Cadmium (Cd) poses a substantial threat to the male reproductive system, as it can induce testicular injury by triggering ferroptosis. The study aimed to explore the protective role and mechanism of Mel in Cd-induced ferroptosis in spermatogonia (spg). Our results demonstrated that Cd disrupted the mitochondrial ultrastructure and induced more autophagosomes in spg. Exposure to Cd resulted in a reduction of the mitochondrial membrane potential of the cells. The transcriptomics analysis revealed significant differences in gene expression associated with ferroptosis and autophagy. Mel could reverse the changes caused by Cd in the genes mentioned above. Furthermore, Cd increased cellular iron content and elevated reactive oxygen species levels, which induced oxidative stress in spg. Mel pretreatment reduced iron accumulation and oxidative damage caused by Cd exposure. Additional studies demonstrated that Cd exposure activated NCOA4-mediated ferritinophagy in spg. Mel pretreatment, as anticipated, inhibited the increased the mRNA and protein expression of ATG5, LC3B, and NCOA4 caused by Cd, ameliorated Cd-caused iron overload and oxidative stress, and protected spg from ferroptosis. Our study provides a therapeutic basis for the use of Mel to treat Cd-induced testicular injury.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Melatonin alleviates ferroptosis triggered by cadmium via regulating ferritinophagy and iron metabolism in spermatogonia
- Date Crossref
- 14/03/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Anhui Medical University Anhui Provincial Key Laboratory of Population Health and Aristogenics / Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes pays non établi dans la noticeUniversité ou école supérieure
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First Affiliated Hospital of Wannan Medical College pays non établi dans la noticeÉtablissement de santé
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Anhui University of Traditional Chinese Medicine The Second Affiliated Hospital of Anhui pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital of Anhui Medical University pays non établi dans la noticeÉtablissement de santé
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Anhui University pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health Department of Health Inspection and Quarantine pays non établi dans la noticeUniversité ou école supérieure
Anhui Provincial Key Laboratory of Population Health and Aristogenics / Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes — Anhui Medical University, First Affiliated Hospital of Wannan Medical College et The Second Affiliated Hospital of Anhui — Anhui University of Traditional Chinese Medicine, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.