Yanyan Li

Non‑nucleoside inhibitors of SARS‑CoV‑2 RdRp identified by high‑throughput screening and an approach to their mechanism of action by comparative studies

Shangqian Wu, Chuwei Yang, Dongying Li, Yuzheng Zhou et autres

Abstract The RNA-dependent RNA polymerase (RdRp) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pivotal antiviral target due to its essential role in viral replication and high conservation. Non-nucleoside analog inhibitors (NNIs) are a promising class of antiviral compounds that …

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Systemic Barriers to Establishing Plant-Based Pork Supply Chains in China: An FDM–DEMATEL Analysis

Muzaffar Iqbal, Youqing Fan, Yanyan Li, Di Zhu et autres

China’s pork sector is a major component of the national food system. Establishing plant-based pork supply chains requires coordination across production, quality control, infrastructure, logistics, information exchange, and market formation. However, previous studies generally examine these barriers separately, limiting understanding of how …

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Structure and druggable conformation of the homodimeric lipoprotein transporter of Acinetobacter baumannii

Yanyan Li, Maofu Liao, Song Zhang

Structural maps (.mrc) and models (.pdb) of AbLol in different states.

Structure and druggable conformation of the homodimeric lipoprotein transporter of Acinetobacter baumannii

Yanyan Li, Maofu Liao, Song Zhang

Structural maps (.mrc) and models (.pdb) of AbLol in different states.

Cryo–electron microscopy structures of human cone visual pigments

Peng Qi, Jian Li, Haihai Jiang, Xinyu Cheng et autres

Human trichromatic color vision relies on three cone opsins [long-, middle-, and short-wavelength-sensitive opsins (LWS-, MWS-, and SWS-opsins, respectively)], whereas scotopic rod vision is mediated by rhodopsin. Although the structure of rhodopsin was solved more than 20 years ago, cone opsin structures …

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Agricultural Green Development as a Buffer Against Growing-Season Climate Extremes: Evidence from China’s Yellow River Basin

Yanyan Li, Naniram Dulal, Di Zhu, Xiaowen Dai et autres

Agricultural green development (AGD) is usually evaluated by its average productivity and environmental effects, but its value may be more visible when crop production is exposed to severe growing-season climate stress. This study examines whether AGD acts as a state-dependent buffer against …

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Global-scale prevalence of low nutrient use efficiency across major crops

Ji Liu, Hai Wang, Josep Peñuelas, Juan Mou et autres

Enhancing nitrogen (N) and phosphorus (P) use efficiency (NUE and PUE) is essential for advancing sustainable agriculture and reducing dependency on non-renewable fertilizers. However, the long-term dynamics of NUE and PUE across major crops remain poorly understood at a global scale. Here, …

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The Renal Micro-Vasculopathy and Systemic Aldosterone-Renin Ratio (ARR) in Type 2 Diabetic Patients—A Retrospective Real-World Study

Song Wen, Zhimin Xu, Min Gong, Congcong Wang et autres

Objective: To investigate whether the imbalanced aldosterone to renin ratio (ARR) is associated with renal micro-vasculopathy in type 2 diabetes mellitus (T2DM). Materials and Methods: Data from 471 T2DM patients were retrospectively analyzed from 2019 to 2023. Blood samples were collected for …

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Natural convection heat transfer coefficients for Chinese children and adolescents

Yunfei Kang, Xue Wang, Yanyan Li, Huihui Zhao et autres

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Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization

Dongteng Liu, Binjie Jiang, Xudong Zhao, Yanyan Li et autres

In mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown. Here, we report that pachynema-specific knockout of Speedy A (SpdyA) from telomeres caused persistent Y-X NH synapsis, with the …

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Global-scale shifts in marine ecological stoichiometry over the past 50 years

Ji Liu, Hai Wang, Juan Mou, Josep Peñuelas et autres

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Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome

Nan Wang, Yongheng Gao, Peini Xue, Salim Surani et autres

Background: Acute respiratory distress syndrome (ARDS) is characterized by elevated pulmonary microvascular permeability; however, the role of circular RNAs (circRNAs) in this process remains unclear. Our study aims to discover the mechanism underlying the role of circRNA in pulmonary microvascular permeability in …

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