Yuanyuan Zhang

Investigating working memory and brain activation in major depressive disorder with and without insomnia: insights from functional near-infrared spectroscopy (fNIRS)

Yanli Li, Chao Zheng, Yanni Li, Yübo Wang et autres

Abstract Background Major depressive disorder (MDD) frequently coexists with insomnia, a comorbidity that exacerbates cognitive deficits, particularly in working memory (WM). While previous research has established links between insomnia and impaired brain function, the barin functional indicators associated with WM deficits in …

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Association of dietary nutrient intake with reproductive lifespan in women: a cross-sectional analysis using weighted quantile sum regression in NHANES 2001–2018

Yuanyuan Zhang, Wenjun Xiao, Xiaoyi Zhu, Ying‐Jie Zhu et autres

BACKGROUND: The female reproductive lifespan, defined as the period from menarche to natural menopause, is a critical determinant of ovarian reserve and long-term health outcomes in women. Although nutritional factors are recognized as modifiable regulators of reproductive aging, comprehensive evidence regarding the …

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Sevoflurane impairs neurogenesis and cognitive function by inhibiting fatty acid β-oxidation in neural stem/progenitor cells of neonatal rats

Peng Jia, Kui Wang, Yiqin Cheng, Yan Zhang et autres

BACKGROUND: Sevoflurane impairs neurogenesis and cognitive function in the developing brain; however, the underlying mechanisms remain unclear. This study aimed to investigate the role of fatty acid β-oxidation (FAO) in neural stem/progenitor cells (NSPCs) as a potential factor in sevoflurane-induced neurogenesis inhibition …

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The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is associated with early onset type 2 diabetes with NAFLD: a cross-sectional study in China

N Wu, Yingqun Ni, R. Stephanie Huang, Junhua Wang et autres

Background: The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel composite lipid biomarker associated with metabolic diseases. This study aims to explore the potential relationship between early-onset type 2 diabetes mellitus combined with NAFLD and NHHR. Methods: A …

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Association Between Walking Speed and Arthritis Risk: Evidence from Five International Aging Cohorts

Hui Li, Yuanyuan Zhang, Jun Luo, Miao‐Miao Hua et autres

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Sevoflurane-induced gut microbiota dysbiosis drives adolescent neurobehavioral deficits in neonatal rats: Protective role of eicosapentaenoic acid

Pei Fan, Kui Wang, Haidong Wei, Liufei Yang et autres

, etc., also decreased glyceryl palmitate, and eicosapentaenoic acid. Bioinformatics analysis indicated that specific gut microbiota and metabolites were related to behavioral changes. Notably, EPA supplementation alleviated these neurobehavioral deficits. These findings support a role for the gut microbiota and its metabolites …

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A water-soluble fluorescent probe derived from fish collagen peptides for multi-targeted detection of Cu2+ and Zn2+ ions via AIE and ESIPT mechanisms

Yuanyuan Zhang, Yunxuan Wang, Zhijun Hu, Penghui Xu et autres

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Augmentation of PRDX1–DOK3 interaction alleviates rheumatoid arthritis progression by suppressing plasma cell differentiation

Wenzhen Dang, Xiaomin Wang, Hongbo Li, Yixuan Xu et autres

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation and joint damage, accompanied by the accumulation of plasma cells, which contributes to its pathogenesis. Understanding the genetic alterations occurring during plasma cell differentiation in RA can deepen our comprehension …

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Effects of fish meal replacement by Clostridium autoethanogenum protein on growth performance, serum biochemistry, antioxidant capacity, immune responses and muscle quality in black carp (Mylopharyngodon piceus)

Yifan Fu, Jinjing Zhang, Yuanyuan Zhang, Jiaxing Yu et autres

The study investigated the growth performance, serum biochemistry, antioxidant and immune responses, and muscle quality of black carp ( Mylopharyngodon piceus ) fed dietary fish meal replaced by Clostridium autoethanogenum protein (CAP) (0 %, 20 %, 40 %, 60 %, 80 %, …

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Effects of Fish Meal Replacement by Clostridium Autoethanogenum Protein on Growth Performance, Serum Biochemistry, Antioxidant Capacity, Immune Responses and Muscle Quality in Black Carp (Mylopharyngodon Piceus)

Yifan Fu, Jinjing Zhang, Yuanyuan Zhang, Jiaxing Yu et autres

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Pretreatment with tetramethylpyrazine alleviated the impairment of learning and memory induced by sevoflurane exposure in neonatal rats

Kui Wang, Haidong Wei, Liufei Yang, Shuyue Zhang et autres

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Unveiling a Potent Small Molecule Disruptor for RNA G-Quadruplexes Tougher Than DNA G-Quadruplex Disruption

Xingyu Liu, Qianqian Qi, Wei Xiong, Wei Shen et autres

This research presents a unique small molecule characterized by its ability to effectively disrupt RNA G-quadruplexes (G4s), which are notably more stable than their DNA counterparts. We conducted a comprehensive series of in vitro experiments to thoroughly assess the disruptive capabilities of …

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