Junhua Wang

Genomic epidemiology of Salmonella Typhimurium in Guizhou, China (2019–2023): high prevalence of MDR, plasmid-associated resistance, and shared genomic lineages

Ge Zhu, Lv You, Limei Wu, Yanmin Liu et autres

Salmonella Typhimurium ( S . Typhimurium) is a leading cause of bacterial gastroenteritis worldwide, and its escalating antimicrobial resistance (AMR) poses a critical threat to global public health. Nevertheless, epidemiological and genomic data for this pathogen in Guizhou Province remain limited. We …

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Genomic surveillance reveals escalating antimicrobial resistance and plasmid diversity in clinical Salmonella 1,4,[5],12:i:- ST34 isolates from Guizhou Province, China

Ge Zhu, Lv You, Deyu Li, Junhua Wang et autres

Introduction Salmonella 1,4,[5],12:i:- ST34 has emerged as a significant public health issue due to its association with various antimicrobial resistance genes (ARGs) and transferable plasmids. However, its genomic characteristics and potential influence on public health in Guizhou have not been comprehensively assessed. …

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Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance

Junhua Wang, Yinshen Wee, Thomas Jacob, Aaron Rogers et autres

Abstract The intrinsic ability of cancer cells to evade death underpins tumorigenesis, progression, metastasis, and the survival of drug-tolerant persister (DTP) cells. Herein, we discovered that the small GTPase ARF6 plays a central role in tumor survival by fortifying RAF oncoprotein levels. …

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Genomic surveillance reveals escalating antimicrobial resistance and plasmid diversity in clinical Salmonella 1,4,[5],12:i:- ST34 isolates from Guizhou Province, China.

Ge Zhu, Lv You, Deyu Li, Junhua Wang et autres

Introduction: 1,4,[5],12:i:- ST34 has emerged as a significant public health issue due to its association with various antimicrobial resistance genes (ARGs) and transferable plasmids. However, its genomic characteristics and potential influence on public health in Guizhou have not been comprehensively assessed. Methods: …

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FGF1-FGFR2 axis regulated by nuclear receptor RORγ represents an effective strategy in intrahepatic cholangiocarcinoma

Zhanfeng Gu, Xiaojuan Wang, Hong Wang, Junhua Wang et autres

Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive malignancy with limited therapeutic options. Although targeted therapies like pemigatinib provide partial clinical benefits, acquired resistance remains a significant challenge. Through integrative bioinformatics analysis of public datasets and immunohistochemical validation, we identified the retinoid-related orphan …

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The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is associated with early onset type 2 diabetes with NAFLD: a cross-sectional study in China

N Wu, Yingqun Ni, R. Stephanie Huang, Junhua Wang et autres

Background: The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel composite lipid biomarker associated with metabolic diseases. This study aims to explore the potential relationship between early-onset type 2 diabetes mellitus combined with NAFLD and NHHR. Methods: A …

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Multi‐pathway‐driven hepatic protection: Semaglutide combined with HIIT counteracts diabetic liver injury in db/db mice

Yongfu Liu, Shenglong Le, Yuxin Xiao, Xiaoyan Chen et autres

OBJECTIVE: Investigate the impact and mechanism of semaglutide (Sema) combined with high-intensity interval training (HIIT) on hepatic glucose/lipid metabolism in db/db mice using untargeted metabolomics. METHODS: Db/db mice were divided into model control, Sema alone, and Sema + HIIT groups, with db/m …

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Erucamide regulates retinal neurovascular crosstalk

Guoqin Wei, Shreyosree Chatterjee, Qinglin Yang, Sanahan Vijayakumar et autres

Abstract Neurovasculoglial crosstalk is critical in establishing and maintaining a functional neurovascular unit. Breakdown in the unit is central to many neurodegenerative disorders of the CNS of which the retina is a component. A growing literature indicated that primary fatty acid amides …

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Effects of a 6-week semi-supervised exercise training program on physical fitness and mental health in post-COVID-19 healthcare workers: a randomized clinical trial

Feng Gao, Fei Liu, Yongfu Liu, Zhi Li et autres

BACKGROUND: Healthcare workers rank among the groups that are most vulnerable to the SARS-CoV-2 infection. Deterioration in physical fitness and mental health is a common manifestation in the post-COVID-19 person, which require specific and effective treatment. This study aimed to evaluate the …

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Comorbidity Patterns of Common Diseases Among Children and Adolescents in Renhuai City, Guizhou Province, China: Latent Class Analysis

Yi‐Hsin Yang, Yayu Yang, Junhua Wang, Zou Ya et autres

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The combined application of cis-cyclo(L-Phe-L-Pro) with antimicrobial proline-based 2,5-diketopiperazines significantly enhances anti-breast cancer activity by selectively targeting cancer stem cells

Rui Liu, Bo Sun, Sa-Ouk Kang, Yeonju Hong et autres

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A Rare Case of Ischial Tubercle Pressure Sore with Secondary Periperineal Necrotizing Fasciitis

Peiqi Wang, Yiyang Liu, Junhua Wang, Qiaofeng Guo et autres

BACKGROUND: Perineal necrotizing fasciitis, or Fournier's gangrene, is a rare but rapidly progressing condition characterized by fascial necrosis. It is a severe, potentially life-threatening infection requiring prompt diagnosis and standardized treatment to optimize patient outcomes. CASE PRESENTATION: A 48-year-old woman with poorly …

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