Accès ouvert
2026
article
OpenAlex
Simon Holzinger, Leo Schmutterer, Victoria Marie Rothe, Maria Theresia Watzlowik et autres
High-resolution analysis of cellular chromatin structure is crucial for uncovering developmental and cell-type-specific regulatory networks. We developed the nucDetective pipeline to provide a comprehensive evaluation of chromatin organisation. This involves assessing nucleosome positioning, occupancy, fuzziness, and array regularity. The pipeline was benchmarked …
de
(code pays fourni par la source)
2026
article
OpenAlex
Andreas Ettner-Sitter, Leo Schmutterer, Valentin Bergér, Amelie Rödel et autres
During eukaryotic gene expression, the synthesis, processing, and nuclear export of mRNAs are tightly linked, and the transcription and export (TREX) complex plays a central role. TREX consists of a hexameric core termed THO that can associate with additional proteins including various …
de
(code pays fourni par la source)
2025
peer-review
OpenAlex
Simon Holzinger, Leo Schmutterer, Victoria Marie Rothe, Maria Theresia Watzlowik et autres
de
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Simon Holzinger, Leo Schmutterer, Victoria Marie Rothe, Maria Theresia Watzlowik et autres
Abstract High-resolution analysis of cellular chromatin structure is crucial for uncovering developmental and cell-type-specific regulatory networks. We developed the nucDetective pipeline to provide a comprehensive evaluation of chromatin organisation. This involves assessing nucleosome positioning, occupancy, fuzziness, and array regularity. The pipeline was …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Sara Wernig-Zorc, Fabian Kugler, Leo Schmutterer, Patrick Räß et autres
Micrococcal nuclease sequencing is the state-of-the-art method for determining chromatin structure and nucleosome positioning. Data analysis is complex due to the AT-dependent sequence bias of the endonuclease and the requirement for high sequencing depth. Here, we present the nucleosome-based MNase accessibility (nucMACC) …
de
(code pays fourni par la source)