Andreas Ettner-Sitter

Artificial intelligence–based quantification of epidermal proliferation and apoptosis in human skin

Valeria Mei, Sandra Maurer, Philipp Kainz, Andreas Ettner-Sitter et autres

Although artificial intelligence is rapidly advancing, its application in translational dermatological research remains limited. In this study, we established an artificial intelligence–based image analysis workflow for the quantification of proliferation and apoptosis within the human epidermis using 3,3′-diaminobenzidine–based immunohistochemical staining. Human skin …

Artificial intelligence–based quantification of epidermal proliferation and apoptosis in human skin

Valeria Mei, Sandra Maurer, Philipp Kainz, Andreas Ettner-Sitter et autres

Although artificial intelligence is rapidly advancing, its application in translational dermatological research remains limited. In this study, we established an artificial intelligence-based image analysis workflow for the quantification of proliferation and apoptosis within the human epidermis using 3,3'-diaminobenzidine-based immunohistochemical staining. Human skin …

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Gold-modified superparamagnetic iron oxide nanoparticles: Magnetic accumulation under flow conditions and toxicity evaluation in vitro and in vivo

Hatice Genç, Rene Stein, Andreas Ettner-Sitter, Teresa Siegert et autres

Superparamagnetic iron oxide nanoparticles (SPIONs) enable enhanced magnetic drug targeting and theranostic applications. This study investigated potential toxic effects of SPIONs developed for drug delivery applications. Gold-modified SPIONs (SPION-Au-Cit) produced via alkaline precipitation were analyzed in terms of their hydrodynamic size, ζ-potential, …

Gold-modified superparamagnetic iron oxide nanoparticles: Magnetic accumulation under flow conditions and toxicity evaluation in vitro and in vivo

Hatice Genç, Rene Stein, Andreas Ettner-Sitter, Teresa Siegert et autres

Superparamagnetic iron oxide nanoparticles (SPIONs) enable enhanced magnetic drug targeting and theranostic applications. This study investigated potential toxic effects of SPIONs developed for drug delivery applications. Gold-modified SPIONs (SPION-Au-Cit) produced via alkaline precipitation were analyzed in terms of their hydrodynamic size, ζ-potential, …

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Gold-modified superparamagnetic iron oxide nanoparticles: Magnetic accumulation under flow conditions and toxicity evaluation in vitro and in vivo

Hatice Genç, Rene Stein, Andreas Ettner-Sitter, Teresa Siegert et autres

Superparamagnetic iron oxide nanoparticles (SPIONs) enable enhanced magnetic drug targeting and theranostic applications. This study investigated potential toxic effects of SPIONs developed for drug delivery applications. Gold-modified SPIONs (SPION-Au-Cit) produced via alkaline precipitation were analyzed in terms of their hydrodynamic size, ζ-potential, …

THO5 subunit of the Arabidopsis thaliana TREX complex: role in mRNA export and heat tolerance

Andreas Ettner-Sitter, Leo Schmutterer, Valentin Bergér, Amelie Rödel et autres

During eukaryotic gene expression, the synthesis, processing, and nuclear export of mRNAs are tightly linked, and the transcription and export (TREX) complex plays a central role. TREX consists of a hexameric core termed THO that can associate with additional proteins including various …

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Illumination pancreatic cancer angiogenesis: Insights into tumor perfusion and microvascular architecture using the CAM model

Andreas Ettner-Sitter, B.J. Wagner, Tin Aung, Silke Haerteis et autres

Background: Global Cancer Statistics 2020 reported a total of 495773 new cases and 466003 related deaths for pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) represents the fourth leading cause of cancer-related deaths with an overall published five-year survival rate of less than 6%. …

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The CAM Model: An in Vivo Testbed for Molecular Communication Systems

Fardad Vakilipoor, Andreas Ettner-Sitter, Lukas Brand, Sebastian Lotter et autres

Molecular communication (MC) research is increasingly focused on applications within the human body, such as health monitoring and drug delivery, which require testing in realistic and living environments. Thus, elevating experimental MC research to the next level requires developing realistic in vivo …

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Patient-Derived Xenografts Generated from Circulating Cancer Stem Cells in a 3D-In-Vivo Model as a Novel Concept for Research and Clinical Deci-Sion-Making in Pancreatic Cancer

Andreas Ettner-Sitter, B.J. Wagner, Nicolas A. Ihlo, Merle Behr et autres

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The CAM Model: An in vivo Testbed for Molecular Communication Systems

Fardad Vakilipoor, Andreas Ettner-Sitter, Sebastian Lotter, Thiha Aung et autres

Molecular communication (MC) research increasingly focuses on biomedical applications like health monitoring and drug delivery, demanding testing in realistic living environments. Elevating MC research requires developing advanced in vivo testbeds. We introduce the chorioallantoic membrane (CAM) model as the first versatile 3D …

Patient-derived xenografts from circulating cancer stem cells as a preclinical model for personalized pancreatic cancer research

Benedikt J. Wagner, Andreas Ettner-Sitter, Nicolas A. Ihlo, Merle Behr et autres

Patient-derived xenografts (PDXs) provide biologically relevant models and potential platforms for the development of treatment strategies for precision medicine in pancreatic cancer. Furthermore, circulating epithelial tumor cells (CETCs/CTCs) are released into the bloodstream by solid tumors and a rare subpopulation-circulating cancer stem …

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The Chorioallantoic Membrane Model: A 3D in vivo Testbed for Design and Analysis of MC Systems

Maximilian Schäfer, Andreas Ettner-Sitter, Lukas Brand, Sebastian Lotter et autres

Molecular Communications (MC) research is increasingly focused on applications within the human body, such as health monitoring and drug delivery. These applications require testing in realistic and living environments. Thus, advancing experimental MC research to the next level requires the development of …

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