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Bingqing Tang, Jennifer Morvan, Filippo Begal, Koen Kuijpers et autres
Carbon-carbon bond forming reactions are central to medicinal chemistry efforts. Methods which utilise abundant and structurally diverse building blocks can accelerate chemical space exploration in drug discovery. Herein, we report...
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders et autres
Abstract The development of 18 F‐labelled radiotracers is of vital importance for (pre)clinical positron emission tomography (PET) imaging and to guide drug discovery campaigns. State‐of‐the‐art approaches often require labour‐intensive preparation of highly functionalised radiolabelling precursors. This bottleneck impedes analogue generation for optimal …
us, gb, br (code pays fourni par la source)
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders et autres
Abstract The development of 18 F‐labelled radiotracers is of vital importance for (pre)clinical positron emission tomography (PET) imaging and to guide drug discovery campaigns. State‐of‐the‐art approaches often require labour‐intensive preparation of highly functionalised radiolabelling precursors. This bottleneck impedes analogue generation for optimal …
us, gb, br (code pays fourni par la source)
Fabian Hulpia, Wim B. G. Schepens, Susan Lepri, Johan Nicolaï et autres
Abstract Loss of the functional Adenomatous Polyposis Coli (APC-LOF) tumor suppressor gene represents the disease-initiating event in most colorectal cancer (CRC) cases. A newly identified dependency between PRMT5 and APC-LOF suggests that inhibiting PRMT5 may help intercept CRC. To circumvent hematological toxicities …
us, no, il, gb, fr (code pays fourni par la source)
Jennifer Morvan, Bingqing Tang, Pavel Ryabchuk, Evelien Renders et autres
be, us (code pays fourni par la source)
Jennifer Morvan, Bingqing Tang, Pavel Ryabchuk, Evelien Renders et autres
Jennifer Morvan, Koen P. L. Kuijpers, Dayne D. Fanfair, Bingqing Tang et autres
Etherification and amination of aryl halide scaffolds are commonly used reactions in parallel medicinal chemistry to rapidly scan structure-activity relationships with abundant building blocks. Electrochemical methods for aryl etherification and amination demonstrate broad functional group tolerance and extended nucleophile scope compared to …
be (code pays fourni par la source)
Jennifer Morvan, Koen P. L. Kuijpers, Dayne D. Fanfair, Bingqing Tang et autres
Abstract Etherification and amination of aryl halide scaffolds are commonly used reactions in parallel medicinal chemistry to rapidly scan structure–activity relationships with abundant building blocks. Electrochemical methods for aryl etherification and amination demonstrate broad functional group tolerance and extended nucleophile scope compared …
be (code pays fourni par la source)
Jennifer Morvan, Koen P L Kuijpers, Dayne D. Fanfair, Bingqing Tang et autres
Etherification and amination of aryl halide scaffolds are commonly used reactions in parallel medicinal chemistry to rapidly scan structure-activity relationships with abundant building blocks. Electrochemical methods for aryl etherification and amination demonstrate broad functional group tolerance and extended nucleophile scope compared to …
be (code pays fourni par la source)
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