Accès ouvert
2026
article
OpenAlex
Raffaella Riccetti, Alessandro Trentini, Gianmarco Mola, Gloria Brombo et autres
High-density lipoprotein (HDL)-associated paraoxonase-1 (PON1) contributes substantially to the antioxidant and anti-inflammatory functions of HDL. Impairment of these protective properties has been associated with Alzheimer’s disease (AD) and other forms of dementia, particularly those involving neurovascular dysregulation. In the present study, we …
it
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Alessandro Trentini, Raffaella Riccetti, Domenico Sergi, Juana María Sanz et autres
To date, neutrophil-derived myeloperoxidase (MPO), a key mediator of inflammation and oxidative stress, has predominantly been assessed in peripheral fluids by protein concentration rather than enzymatic activity, mainly due to methodological limitations. However, MPO activity directly reflects the enzyme’s cytotoxic potential and …
it
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Giovanni Zuliani, Gloria Brombo, Francesco di Paola Dario, Marco Zuin et autres
Purpose: This study aims to evaluate the association between the insulin resistance as assessed by Triglyceride-Glucose (TyG) index and dementia and to determine whether this relationship varies by sex. Methods: We assessed TyG index in older patients admitted to an Italian Memory …
it, sm
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Gianmarco Mola, Raffaella Riccetti, Domenico Sergi, Alessandro Trentini et autres
High-density lipoproteins (HDLs) protect against atherosclerosis through their antioxidant, anti-inflammatory, and other beneficial properties. Although interest is increasing in uncovering both physiological and external factors that influence these functions, definitive evidence remains lacking in this area. To fill this gap, we assessed …
it
(code pays fourni par la source)
2025
article
OpenAlex
Carlo Cervellati, Alessandro Trentini, Marco Zuin, Gianmarco Mola et autres
Amyloid beta (Aβ) dyshomeostasis is considered the main biological aberration in Alzheimer's Disease (AD) pathology. The interplay between Aβ formation and clearance is predominantly modulated by a disintegrin and a metalloproteinase 10 (ADAM10, α-secretase) and β-site APP Cleaving Enzyme 1 (BACE1), the …
it, ca
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alessandro Trentini, Valentina Rosta, Raffaella Riccetti, Gianmarco Mola et autres
Paraoxonase 1 (PON1) and Paraoxonase 3 (PON3) are enzymes located on the surface of high-density lipoprotein (HDL) and share similar antioxidant properties, possibly modulated by other proteins such as Myeloperoxidase (MPO), which drives the shift from functional to dysfunctional HDL. PON1 has …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Claudia Saraceno, Carlo Cervellati, Alessandro Trentini, Daniela Crescenti et autres
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the two major neurodegenerative diseases causing dementia. Due to similar clinical phenotypes, differential diagnosis is challenging without specific biomarkers. Beta-site Amyloid Precursor Protein cleaving enzyme 1 (BACE1) is a β-secretase pivotal in AD pathogenesis. …
it
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Giovanni Zuliani, Gloria Brombo, Michele Polastri, Tommaso Romagnoli et autres
High levels of blood homocysteine (HCy), a well-known cardiovascular risk factor and promoter of oxidative stress, have been associated with the incidence of cognitive impairment and dementia. Nonetheless, contrasting data are still present on its involvement in the progression from Mild Cognitive …
it
(code pays fourni par la source)