Accès ouvert
2026
preprint
OpenAlex
Sydney B. Blattman, Nabih Maslah, Austin Varela, Karolis Kumpaitis et autres
Abstract Despite the promise of single-cell transcriptomics for understanding cell states in heterogeneous populations, widely used platforms have limited ability to link transcriptional states to somatic mutations within the same cells. Here, we introduce Genotyping in Fixed Transcriptomes (GIFT) for the simultaneous …
us, fr
(code pays fourni par la source)
2026
article
OpenAlex
Kari D. Hagen, Alexander Zerkle, Satvik Arani, Tiffany M. Chase et autres
Giardia intestinalis is a globally prevalent cause of waterborne diarrheal disease, yet about 40% of its proteome remains functionally uncharacterized due to the lack of conserved homologous proteins and limited experimental validation of protein function. To begin addressing this gap, we created …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Xiang Yi, Florian Kleinbeck, Charlene Ching, Lorita Boghospor et autres
Imine reductases (IREDs) have been identified as an important class of biocatalysts to synthesize chiral amines with substantial promise for industrial application. Here, we report the promiscuous imine reductase activity of a glucose dehydrogenase (GDH). Starting from enzyme GDH Rd1bb, a commercial …
us, ch, au
(code pays fourni par la source)