Leon Seeger

Enzyme kinetics shapes the growth response of metabolic networks

Leon Seeger, Fernanda Pinheiro, Michael Lässig

Microbes adjust their metabolism to environmental challenges by changing protein expression levels, metabolite concentrations, and reaction rates. Average expression levels in large proteome sectors change coherently, while individual proteins show divergent shifts even within the same pathway. Here, we establish a metabolic …

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Physiology, Kinetics, and Fitness: Mechanistic Models of Microbial Adaptation

Leon Seeger

Microbes adapt to environmental challenges through physiological plasticity on short timescales and through evolutionary adaptation on longer timescales. Preventing antibiotic resistance, designing effective combination therapies, and preparing for climate change require predicting the speed and limits of microbial adaptation through both mechanisms. …

Resource allocation in biochemically structured metabolic networks

Leon Seeger, Fernanda Pinheiro, Michael Lässig

Abstract Microbes tune their metabolism to environmental challenges by changing protein expression levels, metabolite concentrations, and reaction rates simultaneously. Here, we establish an analytical model for microbial resource allocation that integrates enzyme biochemistry and the global architecture of metabolic networks. We describe …

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