Amy J. Bongetti

Evaluating skeletal muscle dysfunction and recovery in a zymosan model of critical illness in mice

Amy J. Bongetti, Annabel Chee, John H.V. Nguyen, Jin Do Chung et autres

Muscle wasting and weakness are common complications associated with critical illness and admission to the intensive care unit (ICU), which contribute to increased mortality and health deficits post discharge. The mechanisms underlying ICU-acquired muscle weakness (ICU-AW) are incompletely understood, and small-animal models …

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The intensive care medicine research agenda for the management of ICU acquired weakness: a multinational, interprofessional perspective

Sabrina Eggmann, Selina M. Parry, Tessa Broadley, Gordon S. Lynch et autres

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The effect of enteral glycine on plasma glycine and muscle structure, size, and function in the critically ill: A randomized controlled trial

Yasmine Ali Abdelhamid, Amy J. Bongetti, Marissa K. Caldow, Amalia Karahalios et autres

BACKGROUND: Critically ill patients frequently experience severe muscle loss with subsequent physical impairment. In pre-clinical models of muscle wasting, administration of the amino acid glycine attenuates muscle loss. AIMS: To evaluate the plasma availability of enteral glycine and the impact of glycine …

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Evaluating skeletal muscle wasting and weakness in models of critical illness

Amy J. Bongetti, Marissa K. Caldow, Yasmine Ali Abdelhamid, Gordon S. Lynch

Skeletal muscle wasting and weakness are common complications associated with admission to the intensive care unit (ICU), with the loss of muscle mass and function increasing mortality and contributing to physical impairments post-discharge. While our understanding of the pathophysiology of this condition, …

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The Effect of Enteral Glycine on Plasma Glycine and Muscle Loss in Critical Illness

Yasmine Ali Abdelhamid, Amy J. Bongetti, Marissa K. Caldow, Emily Karahalios et autres

Abstract RATIONALE: Glycine attenuates muscle loss in pre-clinical models of muscle wasting. Aim: To evaluate the absorption of enteral glycine and impact of glycine supplementation on muscle loss in critically ill adults. METHODS: Single-centre, placebo-controlled, blinded, randomized clinical trial. Patients anticipated to …

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Enteral glycine supplementation increases plasma and muscle glycine concentrations and may attenuate muscle loss in critical illness

Yasmine Ali Abdelhamid, Amy J. Bongetti, Marissa K. Caldow, Emily Karahalios et autres

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Investigating skeletal muscle dysfunction in a mouse model of critical illness

Amy J. Bongetti, Annabel Chee, Jessie Nguyen, Joo-Hong Chung et autres

Plasma beta‐hydroxy‐beta‐methylbutyrate availability after enteral administration during critical illness after trauma: An exploratory study

Kym Wittholz, Amy J. Bongetti, Kate Fetterplace, Marissa K. Caldow et autres

BACKGROUND: During critical illness skeletal muscle wasting occurs rapidly. Although beta-hydroxy-beta-methylbutyrate (HMB) is a potential treatment to attenuate this process, the plasma appearance and muscle concentration is uncertain. METHODS: This was an exploratory study nested within a blinded, parallel group, randomized clinical …

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