Plasma beta‐hydroxy‐beta‐methylbutyrate availability after enteral administration during critical illness after trauma: An exploratory study
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Le résumé fourni par la source
BACKGROUND: During critical illness skeletal muscle wasting occurs rapidly. Although beta-hydroxy-beta-methylbutyrate (HMB) is a potential treatment to attenuate this process, the plasma appearance and muscle concentration is uncertain. METHODS: This was an exploratory study nested within a blinded, parallel group, randomized clinical trial in which critically ill patients after trauma received enteral HMB (3 g daily) or placebo. Plasma samples were collected at 0, 60, and 180 min after study supplement administration on day 1. Needle biopsies of the vastus lateralis muscle were collected (baseline and day 7 of the HMB treatment intervention period). An external standard curve was used to calculate HMB concentrations in plasma and muscle. RESULTS: Data were available for 16 participants (male n = 12 (75%), median [interquartile range] age 50 [29-58] years) who received placebo and 18 participants (male n = 14 (78%), age 49 [34-55] years) who received HMB. Plasma HMB concentrations were similar at baseline but increased after HMB (T = 60 min: placebo 0.60 [0.44-1.31] µM; intervention 51.65 [22.76-64.72] µM). Paired muscle biopsies were collected from 11 participants (placebo n = 7, HMB n = 4). Muscle HMB concentrations were similar at baseline between groups (2.35 [2.17-2.95]; 2.07 [1.78-2.31] µM). For participants in the intervention group who had the repeat biopsy within 4 h of HMB administration, concentrations were greater (7.2 and 12.3 µM) than those who had the repeat biopsy >4 h after HMB (2.7 and 2.1 µM). CONCLUSION: In this exploratory study, enteral HMB administration increased plasma HMB availability. The small sample size limits interpretation of the muscle HMB findings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Plasma beta‐hydroxy‐beta‐methylbutyrate availability after enteral administration during critical illness after trauma: An exploratory study
- Date Crossref
- 24/03/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Royal Melbourne Hospital Department of Intensive Care pays non établi dans la noticeOrganisme public
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The University of Melbourne Department of Critical Care pays non établi dans la noticeUniversité ou école supérieure
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Melbourne Genomics Health Alliance pays non établi dans la noticeOrganisation à but non lucratif
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Karolinska Institutet pays non établi dans la noticeUniversité ou école supérieure
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Department of Allied Health (Clinical Nutrition) Royal Melbourne Hospital Melbourne Australia pays non établi dans la noticeÉtablissement de santé
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Melbourne Medical School University of Melbourne Melbourne Australia Department of Critical Care pays non établi dans la noticeUniversité ou école supérieure
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Melbourne School of Population and Global Health University of Melbourne Melbourne Australia Centre for Epidemiology and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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Bio21 Institute University of Melbourne Melbourne Victoria Australia Metabolomics Australia pays non établi dans la noticeUniversité ou école supérieure
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Department of Clinical Science Division of Anesthesiology and Intensive Care pays non établi dans la noticeÉtablissement de santé
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Department of Intensive Care Royal Melbourne Hospital Melbourne Australia pays non établi dans la noticeÉtablissement de santé
Department of Intensive Care — The Royal Melbourne Hospital, Department of Critical Care — The University of Melbourne et Melbourne Genomics Health Alliance, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.