Accès ouvert
2026
article
OpenAlex
Nicole S. MacRae, Ken C. Dong, Hiromitsu Harimoto, Andreas Martin
The 26S proteasome is the endpoint of the ubiquitin-proteasome system, an essential pathway for maintaining cellular homeostasis through targeted degradation of misfolded, damaged, and obsolete proteins. Substrates labeled with ubiquitin are directed to the 26S proteasome by binding to one or more …
us
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Accès ouvert
2025
preprint
OpenAlex
Nicole S. MacRae, Ken C. Dong, Hiromitsu Harimoto, Andreas Martin
The 26S proteasome is the endpoint of the ubiquitin-proteasome system, an essential pathway for maintaining cellular homeostasis through targeted degradation of misfolded, damaged, and obsolete proteins. Substrates labeled with ubiquitin are directed to the 26S proteasome by binding to one or more …
us, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Sang Joon Won, Yuxiang Zhang, Christopher J. Reinhardt, Lauren M Hargis et autres
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Sang Joon Won, Yuxiang Zhang, Christopher J. Reinhardt, Nicole S. MacRae et autres
Pioneer transcription factors (TFs) exhibit a specialized ability to bind to and open closed chromatin, facilitating engagement by other regulatory factors involved in gene activation or repression. Chemical probes are lacking for pioneer TFs, which has hindered their mechanistic investigation in cells. …
us
(code pays fourni par la source)