Meganck R.M.

Homotypic antibodies target novel E glycoprotein domains after natural DENV 3 infection/vaccination

Baric R.S, Heinke Conrad, H. J., Ángel Balmaseda et autres

The envelope (E) glycoprotein is the primary target of type-specific (TS) neutralizing antibodies (nAbs) after infection with any of the four distinct dengue virus serotypes (DENV1–4). nAbs can be elicited to distinct structural E domains (EDs) I, II, or III. However, the …

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Generation of Mature DENVs via Genetic Modification and Directed Evolution

Meganck R.M., de Silva, Shan Dong, Baric R.S et autres

Maturation of dengue viruses (DENVs) alters the structure, immunity, and infectivity of the virion and highly mature particles represent the dominant form in vivo. The production of highly mature virions principally relies on the structure and function of the viral premature membrane …

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Durability of Heterologous and Homologous COVID-19 Vaccine Boosts

Roy V, Hauser B.M, Powers J.M, A Chandrashekar et autres

Importance: Antibody responses elicited by current messenger RNA (mRNA) COVID-19 vaccines decline rapidly and require repeated boosting. Objective: To evaluate the immunogenicity and durability of heterologous and homologous prime-boost regimens involving the adenovirus vector vaccine Ad26.COV2.S and the mRNA vaccine BNT162b2. Design, …

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A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity

Deqiu Zhu, Baric R.S, Amila O. De Silva, T Scobey et autres

The four dengue virus serotypes co-circulate globally and cause significant human disease. Dengue vaccine development is challenging because some virus-specific antibodies are protective, while others are implicated in enhanced viral replication and more severe disease. Current dengue tetravalent vaccines contain four live …

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SARS-CoV-2 variant of concern fitness and adaptation in primary human airway epithelia

Bailey A.B, Y L, Tata P.R., Lee R.E. et autres

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Host range, transmissibility and antigenicity of a pangolin coronavirus

M. Mattocks, Meganck R.M., Boyd L. Yount, Yoshihiro Kawaoka et autres

The pathogenic and cross-species transmission potential of SARS-CoV-2-related coronaviruses (CoVs) remain poorly characterized. Here we recovered a wild-type pangolin (Pg) CoV GD strain including derivatives encoding reporter genes using reverse genetics. In primary human cells, PgCoV replicated efficiently but with reduced fitness …

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Reviewer #2 (Public Review): Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop

Meganck R.M., Deanna Zhu, Stephanie Dong, Snoderly-Foster Lisa J. et autres

A hallmark of Dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. Antibody-dependent enhancement is linked …

Reviewer #1 (Public Review): Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion Loop

Meganck R.M., Deanna Zhu, Stephanie Dong, Snoderly-Foster Lisa J. et autres

A hallmark of Dengue virus (DENV) pathogenesis is the potential for antibody-dependent enhancement, which is associated with deadly DENV secondary infection, complicates the identification of correlates of protection, and negatively impacts the safety and efficacy of DENV vaccines. Antibody-dependent enhancement is linked …