Accès ouvert
2026
article
OpenAlex
Jacob R. Enriquez, Zhengjie Zhou, Jennifer B. Nelson, Fei Huang et autres
Effective therapies for type 1 diabetes (T1D) must both restrain immune hyperactivity and reduce β cell susceptibility to destruction. We describe a lipid nanoparticle (LNP) platform for β cell-enriched mRNA delivery that can be further augmented by conjugation to enhanced glucagon-like peptide-1 …
au, us
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Accès ouvert
2025
preprint
OpenAlex
Kierstin L. Webster, Armando A. Puente, Jacob R. Enriquez, Soumyadeep Sarkar et autres
Whereas most autoimmune diseases exhibit female predominance, type 1 diabetes (T1D) occurs more frequently in males after puberty, suggesting a role for sex hormones in disease modification. Because islet β cells actively shape local immune responses, we hypothesized that sex-specific islet responses …
us
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Accès ouvert
2025
article
OpenAlex
Kerim B. Kaylan, Titli Nargis, Kayla Figatner, Jiayi Wang et autres
Obesity-associated inflammation is characterized by macrophage infiltration into peripheral tissues, contributing to the progression of prediabetes and type 2 diabetes. 12-lipoxygenase (12-LOX) catalyzes the formation of pro-inflammatory eicosanoids and promotes the migration of macrophages, yet its role in obesity-associated inflammation remains incompletely …
us
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Accès ouvert
2025
article
OpenAlex
Abhishek Kulkarni, Bernhard Maier, Fei Huang, Kayla Figatner et autres
Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and termination. Although the function of hypusinated eIF5A (eIF5A Hyp ) in cellular proliferation is well characterized, the role of its unhypusinated form (eIF5A Lys ) …
us
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Accès ouvert
2025
preprint
OpenAlex
Kerim B. Kaylan, Titli Nargis, Kayla Figatner, Jiayi Wang et autres
ABSTRACT Obesity-associated inflammation is characterized by macrophage infiltration into peripheral tissues, contributing to the progression of prediabetes and type 2 diabetes (T2D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of pro-inflammatory eicosanoids and is known to promote the migration of macrophages, yet …
us
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Accès ouvert
2024
article
OpenAlex
Titli Nargis, Charanya Muralidharan, Jacob R. Enriquez, Jiayi E. Wang et autres
Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells and involves an interplay between β cells and cells of the innate and adaptive immune systems. We investigated the therapeutic potential of targeting 12-lipoxygenase (12-LOX), an enzyme implicated …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Abhishek Kulkarni, Bernhard Maier, Fei Huang, Kayla Figatner et autres
Abstract Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and termination. Although the function of hypusinated eIF5A (eIF5A Hyp ) in cellular proliferation is well-characterized, the role of its unhypusinated form (eIF5A Lys ) …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Titli Nargis, Charanya Muralidharan, Jacob R. Enriquez, Jiayi E. Wang et autres
ABSTRACT Type 1 diabetes (T1D) is characterized by the autoimmune destruction of insulin-producing β cells and involves an interplay between β cells and cells of the innate and adaptive immune systems. We investigated the therapeutic potential of targeting 12-lipoxygenase (12-LOX), an enzyme …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Charanya Muralidharan, Fei Huang, Jacob R. Enriquez, Jiayi E. Wang et autres
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded proteins, trigger the integrated stress response (ISR), which curtails protein synthesis by phosphorylating …
us, be, au
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Accès ouvert
2024
article
OpenAlex
Alyssa C. Baugh, Justin B. Defalco, Chantel V. Duscent-Maitland, Melissa P. Tumen-Velasquez et autres
ABSTRACT Despite the significant presence of plant-derived tricarboxylic acids in some environments, few studies detail the bacterial metabolism of trans -aconitic acid (Taa) and tricarballylic acid (Tcb). In a soil bacterium, Acinetobacter baylyi ADP1, we discovered interrelated pathways for the consumption of …
us
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Accès ouvert
2023
preprint
OpenAlex
Charanya Muralidharan, Fei Huang, Jacob R. Enriquez, Jiayi E. Wang et autres
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded proteins, trigger the integrated stress response (ISR), which curtails protein synthesis by phosphorylating …
us, be
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Titli Nargis, Advaita Chakraborty, Kayla Figatner, David J. Maloney et autres
Abstract Disclosure: T. Nargis: None. A. Chakraborty: None. K. Figatner: None. D. Maloney: None. M. Boxer: None. S.A. Tersey: None. R.G. Mirmira: None. Type 1 diabetes (T1D) is an autoimmune disorder characterized by islet inflammation (insulitis). We have recently shown that a …
us
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