Nan Sheng

Differential correlations of serum PFASs with thyroid hormones in girls with central and incomplete precocious puberty: a machine learning analysis

Yan Li, Yanan Xing, Xiaoqin Yin, Shaolian Zang et autres

Background: Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants widely detected in Chinese children. Exposure has been associated with thyroid function and altered puberty timing. Objectives: To evaluate associations between serum PFAS concentrations and thyroid hormone (TH) levels in girls with …

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Association between PFAS exposure and bilirubin metabolism: A metabolome-wide analysis in children

Xinhan Zhang, Jie Xiang, Ruolin Qin, Q Liu et autres

Legacy per- and polyfluoroalkyl substances (PFAS) are restricted, but the associations between emerging alternatives and bilirubin metabolism remain understudied in children. We conducted a cross-sectional study using data from Zhejiang ELEVEN cohort during 2021-2024. We analyzed the associations between 37 serum PFAS …

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Per- and polyfluoroalkyl substances may be a novel environmental etiology of nonalcoholic fatty liver: a national cross-sectional study

Xuehua Hu, Nan Sheng, Yue Chen, Wanying Shi et autres

The global prevalence of nonalcoholic fatty liver disease (NAFLD) has been on the rise, with nearly one-quarter of the world’s population currently affected by this condition. Per- and polyfluoroalkyl substances (PFAS) have been suggested as emerging and potentially modifiable environmental risk factors …

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PBPK modeling of C7 HFPO-TA: Linking mouse pharmacokinetics to human exposure and risk through biomonitoring data

Guanzheng Lai, Nan Sheng, Jiayin Dai

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Correction to “Environmental Occurrence, Source Identification, and Health Hazards of Ultrashort-Chain PFAS in the Yangtze River Delta”

Xinchen Miao, Wei Ma, Yawen Tian, Hao Luo et autres

Agentic Discovery of Exchange-Correlation Density Functionals

Titouan Duston, Jiashu Liang, Yuanheng Wang, Weihao Gao et autres

The development of accurate exchange-correlation (XC) functionals remains a longstanding challenge in density functional theory (DFT). The vast majority of XC functionals have been hand designed by human researchers combining physical insight, exact constraints, and empirical fitting. Recent advances in large language …

Mechanistic shift of bioaccumulation from exposure-controlled to trophic-driven for per- and polyfluoroalkyl substances along estuary-open sea gradient

Yanan Li, Yitao Pan, Yi Luo, Fengfeng Dong et autres

• Transition from exposure- to trophic-driven accumulation along estuary-sea gradient. • PFMOAA show noncanonical accumulate pattern deviated from chain-length-dependent trend. • Bioaccumulation ability of long-chained PFAS tended to increase with trophic level. • Short-chained PFAS showed downward trend from invertebrates transferred to …

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Sensitive windows of per- and polyfluoroalkyl substances exposure and children’s intelligence quotient

Yanan Xing, Hong Gan, Dihui Xu, Xiaoyan Wu et autres

Accurate identification of critical windows of neurodevelopmental susceptibility to per- and polyfluoroalkyl substances (PFAS) exposure across the prenatal-to-childhood continuum carries significant public health implications. Although PFAS have been linked to neurodevelopmental impairments, the precise temporal windows of greatest susceptibility remain poorly defined. …

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Quantitative acetylomic analysis reveals a key role of acetylation site 1168K in carbamoyl-phosphate synthase 1 (CPS1) following exposure to PFOA and PFO4DA in mouse liver

Jiamiao Chen, Hua Claria Guo, Nan Sheng, Yitao Pan et autres

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Development of a physiologically based pharmacokinetic model to improve risk assessment of 6:2 Chlorinated polyfluoroalkyl ether sulfonate on human health

Jiamiao Chen, Hongxia Zhang, Jinghua Wang, Yitao Pan et autres

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Structure–dependent association between Perfluoroalkyl and polyfluoroalkyl substances and hemoglobin in the Chinese population: insights from epidemiological analysis and molecular simulations

Xuedan Xu, Keqi Hu, Yingli Qu, Fengfeng Dong et autres

The association between perfluoroalkyl and polyfluoroalkyl substances (PFAS) and hemoglobin (Hb) in general population, as well as their structural-functional relationship remains to be elucidated. We examined both individual and joint-level associations of serum PFAS with Hb concentrations using data from the China …

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Recognition, distribution, and toxicities of novel per- and polyfluoropolyether carboxylic acids

Guanzheng Lai, Jiayin Dai, Nan Sheng

随着全氟辛酸（PFOA）的管控，工业中开始使用结构中含有醚氧键的全氟及多氟聚醚羧酸（PFECA）作为加工助剂替代PFOA。近年来，得益于非靶向筛查和靶向分析技术的快速发展，不同环境介质和生物样品中已陆续检出多种PFECA，浓度呈升高趋势。已有研究发现，六氟环氧丙烷三聚体（HFPO-TA）、六氟环氧丙烷四聚体（HFPO-TeA）等PFECA表现出较PFOA更强的生物累积和毒性效应。相较于传统全氟及多氟烷基物质（PFAS），PFECA结构更为复杂，对环境和生物体的危害机制也可能存在差异。本文围绕PFECA的结构种类、污染水平和毒性效应，从非靶向识别、环境行为、生物及人群暴露水平、毒性效应和分子机制等多个方面对近年来的相关研究进行概述，探讨当前PFECA应用中存在的问题和潜在风险，对未来的研究方向和应用前景进行展望，旨在为PFAS替代品的环境污染及风险评估提供参考，为我国开展PFAS的管控和削减行动提供支撑。