Camille Cohen

A cilia-dependent inflammatory programme links bacterial detection to kidney disease

Amandine Aka, Joran Martin, Fanny Kopp, Teresa Bulfone et autres

ABSTRACT The primary cilium is a microtubule-based sensory organelle projecting from the plasma membrane of most mammalian cells. Genetic defects in ciliary components cause chronic kidney disease (CKD) characterized by heightened production of inflammatory and fibrogenic mediators by tubular epithelial cells. Yet, …

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Accelerated apolipoprotein A-II senile amyloidosis in a plasminogen activator inhibitor-1 knock-out model

Gilles R. Codo, Pauline Duchatelet, Gemma Martinez-Rivas, Alessio Lampis et autres

Unlike in humans, where apolipoprotein A-II amyloidosis (AApoAII) is a rare hereditary form, AApoAII is common in mice and considered as the most frequent amyloidosis type in aged animals. Especial...

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The Case | Febrile pancytopenia with mixed cryoglobulinemia and glomerulonephritis in a traveler

Nicolas Pautrat, Quentin Raimbourg, Camille Cohen

A 70-year-old man, originally from Cape Verde, residing in France since 2020 with frequent return visits, presented with fatigue, unintentional weight loss (15 kg over the past year), and a recent onset of febrile pancytopenia. Physical examination was unremarkable, with no evidence …

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Cardiac Phenotype and Clinical Outcomes in Randall Disease versus Light-Chain Amyloidosis

Martin Nicol, Camille Cohen, Alexis Talbot, Mathilde Baudet et autres

Randall disease is characterized by organ’s deposits of immunoglobulin light chains due to a clonal plasma accumulation secreting monoclonal immunoglobulin chains. In Randall disease, immunoglobuli...

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Senescence as a pathogenic driver in chronic kidney disease: From cellular fate to clinical stratification

Samuel D. Chauvin, Anne Coutrot, Camille Cohen

enable us to identify signatures of senescence beyond histology, and potentially, without the need for invasive tissue sampling.soon join the ranks of specialties poised to benefit from senescence-directed precision medicine.

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PFMG2025–integrating genomic medicine into the national healthcare system in France

Caroline Abadie, Aldja Abderrahmane, Ouarda Abdous, Carine Abel et autres

Integrating genomic medicine into healthcare systems is a health policy challenge that requires continuously transferring scientific advances into clinics and ensuring equal access for patients. France was one of the first countries to integrate genome sequencing into clinical practice at a nationwide …

Epidemiological and clinicopathological characteristics of vascular-limited renal AL amyloidosis

Noémie Senot, Jean Baptiste Gibier, Marion Rabant, Emmanuel Estève et autres

BACKGROUND: Kidney involvement, along with cardiac disease, is the most frequent manifestation of systemic AL amyloidosis, usually resulting in nephrotic-range proteinuria. Rarely, deposits predominantly or exclusively affect the intrarenal arterioles or arteries, with these vascular-limited forms following a distinct clinical course, but …

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Effect of Daratumumab on Renal Outcome in Newly Diagnosed Multiple Myeloma with Light Chain CAST Nephropathy

Daren Yabi, Pierre-Édouard Debureaux, Zoé Van de Wyngaert, Pauline Caillard et autres

Introduction: Renal impairment is common during multiple myeloma (MM) and persistent reduction in kidney function strongly affects long term prognosis. Light chain cast nephropathy (LCCN) is the main mechanism involved in MM renal injury. With typical presentation (acute kidney injury with predominant …

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Kidney involvement in myelodysplastic syndromes

Marie-Camille Lafargue, Jean–Paul Duong Van Huyen, Helmut G. Rennke, Marie Essig et autres

Introduction: The objective of this study was to describe kidney involvement in patients with myelodysplastic syndromes (MDS), their treatments, and outcomes. Methods: We conducted a multicenter retrospective study in seven centers, identifying MDS patients with acute kidney injury (AKI), chronic kidney disease …

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The HUSH epigenetic repressor complex silences PML nuclear bodies-associated HSV-1 quiescent genomes

Simon Roubille, Tristan Escure, Franceline Juillard, Armelle Corpet et autres

Abstract Herpes simplex virus 1 (HSV-1) latently infected neurons show multiple patterns in the distribution of the viral genomes within the nucleus, at least in mouse models. One of the major patterns is characterized by the presence of quiescent HSV-1 genomes trapped …

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Cilia to basement membrane signalling is a biomechanical driver of autosomal dominant polycystic kidney disease

Manal Mazloum, Brice Lapin, Amandine Viau, Rushdi Alghamdi et autres

Abstract Autosomal dominant polycystic kidney disease (ADPKD), which affects around 4 million patients worldwide, is characterized by the formation of multiple tubule derived cysts, which grossly enlarge both kidneys and progressively compromise renal function. ADPKD mainly results from mutations in PKD1 , …

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Hemostasis dysfunction induces senile APOA2 amyloidosis in a mouse model PA49 (#560)

Christophe Sirac, Gemma Martinez-Rivas, BENDER Sébastien, Camille Cohen