Cilia–to–basement membrane signaling is a biomechanical driver in models of autosomal dominant polycystic kidney disease
Manal Mazloum, Brice Lapin, Rushdi Alghamdi, Jessica Vandensteen et autres
Autosomal dominant polycystic kidney disease (ADPKD), the leading genetic cause of kidney failure, results from loss-of-function mutations in PKD1, encoding polycystin-1 (PC1). PC1 localizes to the primary cilium. In the absence of PC1, adverse signaling from the primary cilium orchestrates cyst formation, …
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